Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle–Immune Cell Interactions in Human Blood

ACS Nano ◽  
2021 ◽  
Author(s):  
Jiaying Song ◽  
Yi Ju ◽  
Thakshila H. Amarasena ◽  
Zhixing Lin ◽  
Srinivas Mettu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Human Blood ◽  
Immune Cell ◽  
Ex Vivo ◽  
Cell Interactions ◽  
Molecular Architecture ◽  
Poly Ethylene Glycol ◽  
Particle Assembly ◽  
Poly Ethylene

The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes

2004 ◽  
Vol 97 (1) ◽  
pp. 143-156 ◽  
Author(s):  
Mangesh C. Deshpande ◽  
Martyn C. Davies ◽  
Martin C. Garnett ◽  
Philip M. Williams ◽  
David Armitage ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Cellular Interaction ◽  
Molecular Architecture ◽  
Poly Ethylene Glycol ◽  
Dna Complexes ◽  
Poly Ethylene

Peptide functionalized poly(l-lysine)-g-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma

Biomaterials ◽  
2003 ◽  
Vol 24 (27) ◽  
pp. 4949-4958 ◽  
Author(s):  
S. Tosatti ◽  
S.M.De Paul ◽  
A. Askendal ◽  
S. VandeVondele ◽  
J.A. Hubbell ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Blood Plasma ◽  
Protein Adsorption ◽  
Human Blood ◽  
Human Blood Plasma ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Na Kyeong Lee ◽  
Chi-Pin James Wang ◽  
Jaesung Lim ◽  
Wooram Park ◽  
Ho-Keun Kwon ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Immune Cell ◽  
Plga Nanoparticles ◽  
Antibody Fragments ◽  
Full Length ◽  
Cell Targeting ◽  
Poly Ethylene Glycol ◽  
Delivery Technique ◽  
Poly Ethylene

AbstractAntibodies have been widely used to provide targeting ability and to enhance bioactivity owing to their high specificity, availability, and diversity. Recent advances in biotechnology and nanotechnology permit site-specific engineering of antibodies and their conjugation to the surfaces of nanoparticles (NPs) in various orientations through chemical conjugations and physical adhesions. This study proposes the conjugation of poly(lactic-co-glycolic acid) (PLGA) NPs with antibodies by using two distinct methods, followed by a comparison between the cell-targeting efficiencies of both techniques. Full-length antibodies were conjugated to the PLGA-poly(ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) NPs through the conventional carbodiimide coupling reaction, and f(ab′)2 antibody fragments were conjugated to the PLGA-poly(ethylene glycol)-maleimide(PLGA-PEG-Mal) NPs through interactions between the f(ab′)2 fragment thiol groups and the maleimide located on the nanoparticle surface. The results demonstrate that the PLGA nanoparticles conjugated with the f(ab′)2 antibody fragments had a higher targeting efficiency in vitro and in vivo than that of the PLGA nanoparticles conjugated with the full-length antibodies. The results of this study can be built upon to design a delivery technique for drugs through biocompatible nanoparticles.

Complete Identification of Proteins Responsible for Human Blood Plasma Fouling on Poly(ethylene glycol)-Based Surfaces

Langmuir ◽  
2013 ◽  
Vol 29 (10) ◽  
pp. 3388-3397 ◽  
Author(s):  
Tomáš Riedel ◽  
Zuzana Riedelová-Reicheltová ◽  
Pavel Májek ◽  
César Rodriguez-Emmenegger ◽  
Milan Houska ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Blood Plasma ◽  
Human Blood ◽  
Human Blood Plasma ◽  
Poly Ethylene Glycol ◽  
Complete Identification ◽  
Poly Ethylene

Effect of molecular architecture on micellization, drug loading and releasing of multi-armed poly(ethylene glycol)-b-poly(ε-caprolactone) star polymers

2013 ◽  
Vol 291 (8) ◽  
pp. 1817-1827 ◽  
Author(s):  
Hyung Jun Lim ◽  
Hyunsuk Lee ◽  
Keon Hyeong Kim ◽  
June Huh ◽  
Cheol-Hee Ahn ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Drug Loading ◽  
Star Polymers ◽  
Molecular Architecture ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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