Rough Carbon–Iron Oxide Nanohybrids for Near-Infrared-II Light-Responsive Synergistic Antibacterial Therapy

ACS Nano ◽  
2021 ◽  
Author(s):  
Zhiwen Liu ◽  
Xiaoyi Zhao ◽  
Bingran Yu ◽  
Nana Zhao ◽  
Chen Zhang ◽  
...  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ahmad Abulfathi Umar ◽  
Muhamad Fazly Abdul Patah ◽  
Faisal Abnisa ◽  
Wan Mohd Ashri Wan Daud

AbstractMagnetic hyperthermia therapy (MHT) is a highly promising therapeutic modality for the treatment of different kinds of cancers and malignant tumors. The therapy is based on the concept that; iron oxide nanoparticles deposited at cancer sites can generate heat when exposed to an alternating current magnetic field or near infrared radiation and consequently destroying only the cancer cells by exploiting their vulnerability to heat. The fact that the treatment is at molecular level and that iron oxide nanoparticles provide more guided focus heating justifies its efficacy over treatment such as surgery, radiation therapy and chemotherapy. Nevertheless, the spread of MHT as the next-generation therapeutics has been shadowed by insufficient heating especially at the in vivo stage. This can be averted by modifying the iron oxide nanoparticle structure. To this end, various attempts have been made by developing a magnetic hybrid nanostructure capable of generating efficient heat. However, the synthesis method for each component (of the magnetic hybrid nanostructure) and the grafting process is now an issue. This has a direct effect on the performance of the magnetic hybrid nanostructure in MHT and other applications. The main objective of this review is to detail out the different materials, methods and characterization techniques that have been used so far in developing magnetic hybrid nanostructure. In view of this, we conducted a comprehensive review and present a road map for developing a magnetic hybrid nanostructure that is capable of generating optimum heat during MHT. We further summarize the various characterization techniques and necessary parameters to study in validating the efficiency of the magnetic hybrid nanostructure. Hopefully, this contribution will serve as a guide to researchers that are willing to evaluate the properties of their magnetic hybrid nanostructure.


2021 ◽  
Vol 17 (2) ◽  
pp. 205-215
Author(s):  
Zhenbo Sun ◽  
Mingfang Luo ◽  
Jia Li ◽  
Ailing Wang ◽  
Xucheng Sun ◽  
...  

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.


2017 ◽  
Vol 25 (3) ◽  
pp. 845-853 ◽  
Author(s):  
Xiaoqin Wang ◽  
Yufei Yang ◽  
Yong Zhang ◽  
Qiaoqin Li ◽  
Ming Gong ◽  
...  

2018 ◽  
Vol 6 (9) ◽  
pp. 2460-2471 ◽  
Author(s):  
Xiuhua Wang ◽  
Lei Tan ◽  
Xiangmei Liu ◽  
Zhenduo Cui ◽  
Xianjin Yang ◽  
...  

Near infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapidin situdisinfection of bacterially infected artificial implants due to its penetration ability into tissues.


2016 ◽  
Vol 17 (3/4) ◽  
pp. 189
Author(s):  
Jirapat Ananpattarachai ◽  
Pattra Aphaiphak ◽  
Rokarn Ard ong ◽  
Puangrat Kajitvichyanukul ◽  
Yung Tse Hung

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