Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models

ACS Nano ◽  
2020 ◽  
Vol 14 (12) ◽  
pp. 16984-16996
Author(s):  
Dengshuai Wei ◽  
Yingjie Yu ◽  
Xingcai Zhang ◽  
Yongheng Wang ◽  
Hao Chen ◽  
...  
Keyword(s):  
Redox Balance ◽  
Patient Derived Xenograft ◽  
Xenograft Models ◽  
Chemotherapy Efficacy ◽  
Intracellular Redox

scholarly journals Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient Derived Xenograft Models

Hepatology ◽  
2021 ◽  
Author(s):  
Michael Edward Johnston ◽  
Maria Prates Rivas ◽  
Delphine Nicolle ◽  
Aurore Gorse ◽  
Ruhi Gulati ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Patient Derived Xenograft ◽  
Xenograft Models

scholarly journals PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii142.3-iii142
Author(s):  
Sebastian Brabetz ◽  
Susanne N. Groebner ◽  
Huriye Seker-Cin ◽  
Norman L. Mack ◽  
Volker Hovestadt ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Patient Derived Xenograft ◽  
Xenograft Models ◽  
Pediatric Brain

scholarly journals Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Reid T. Powell ◽  
Abena Redwood ◽  
Xuan Liu ◽  
Lei Guo ◽  
Shirong Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Human Tumor ◽  
The United States ◽  
Glutathione Metabolism ◽  
Subtype Selectivity ◽  
Patient Derived Xenograft ◽  
Treatment Naïve ◽  
Xenograft Models

Abstract Triple-negative breast cancer (TNBC) accounts for 15–20% of breast cancer cases in the United States, lacks targeted therapeutic options, and is associated with a 40–80% risk of recurrence. Thus, identifying actionable targets in treatment-naïve and chemoresistant TNBC is a critical unmet medical need. To address this need, we performed high-throughput drug viability screens on human tumor cells isolated from 16 patient-derived xenograft models of treatment-naïve primary TNBC. The models span a range of TNBC subtypes and exhibit a diverse set of putative driver mutations, thus providing a unique patient-derived, molecularly annotated pharmacologic resource that is reflective of TNBC. We identified therapeutically actionable targets including kinesin spindle protein (KSP). The KSP inhibitor targets the mitotic spindle through mechanisms independent of microtubule stability and showed efficacy in models that were resistant to microtubule inhibitors used as part of the current standard of care for TNBC. We also observed subtype selectivity of Prima-1Met, which showed higher levels of efficacy in the mesenchymal subtype. Coupling pharmacologic data with genomic and transcriptomic information, we showed that Prima-1Met activity was independent of its canonical target, mutant p53, and was better associated with glutathione metabolism, providing an alternate molecularly defined biomarker for this drug.

Patient-derived xenograft models for the study of benign human neoplasms

2021 ◽  
Vol 120 ◽  
pp. 104630
Author(s):  
Juliana Cristina de Souza ◽  
Lucyene Miguita ◽  
Ricardo Santiago Gomez ◽  
Carolina Cavaliéri Gomes
Keyword(s):  
Patient Derived Xenograft ◽  
Xenograft Models

scholarly journals GENE-40. CIRCULATING TUMOR DNA ANALYSIS IN PATIENT-DERIVED XENOGRAFT MODELS OF GLIOBLASTOMA

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi101-vi101
Author(s):  
Nieves Perdigones ◽  
Sydney Connor ◽  
Lauren Hartman ◽  
Tania Contente-Cuomo ◽  
George Reid ◽  
...  
Keyword(s):  
Dna Analysis ◽  
Circulating Tumor Dna ◽  
Patient Derived Xenograft ◽  
Xenograft Models ◽  
Tumor Dna

Abstract 914: Activity of SGN-B6A in patient-derived xenograft models of non-small cell lung cancer

2021 ◽  
Author(s):  
Robert P. Lyon ◽  
John J. Gosink ◽  
Christopher J. Hale ◽  
Jackie L. Stilwell ◽  
Sean Allred ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Patient Derived Xenograft ◽  
Xenograft Models

Glyap1 regulates pneumocandin B0 synthesis by controlling the intracellular redox balance in Glarea lozoyensis

2021 ◽  
Author(s):  
Yan Dong ◽  
Lei Zhang ◽  
Weiting Zhang ◽  
Jianan Cao ◽  
Yiping Wei ◽  
...  
Keyword(s):  
Redox Balance ◽  
Intracellular Redox
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