Multifunctional Supramolecular Hydrogel for Prevention of Epidural Adhesion after Laminectomy

ACS Nano ◽  
2020 ◽  
Vol 14 (7) ◽  
pp. 8202-8219 ◽  
Author(s):  
Yan Wang ◽  
Lanlan Li ◽  
Yongchang Ma ◽  
Yong Tang ◽  
Yang Zhao ◽  
...  
Keyword(s):  
Supramolecular Hydrogel ◽  
Epidural Adhesion

scholarly journals Clinical Efficacy and Safety of Silicone Elastomer Sheet during Decompressive Craniectomy: Anti-Adhesive Role in Cranioplasty

2021 ◽  
Vol 11 (1) ◽  
pp. 124
Author(s):  
Young Ha Kim ◽  
Chi Hyung Lee ◽  
Chang Hyeun Kim ◽  
Dong Wuk Son ◽  
Sang Weon Lee ◽  
...  
Keyword(s):  
Decompressive Craniectomy ◽  
Fluid Collection ◽  
Multivariate Logistic Regression Analysis ◽  
Operation Time ◽  
Silicone Elastomer ◽  
Control Group ◽  
Estimated Blood Loss ◽  
Adhesion Tissue ◽  
Skull Bone Defect ◽  
Epidural Adhesion

(1) Background: Cranioplasty is a surgery to repair a skull bone defect after decompressive craniectomy (DC). If the process of dissection of the epidural adhesion tissue is not performed properly, it can cause many complications. We reviewed the effect of a silicone elastomer sheet designed to prevent adhesion. (2) Methods: We retrospectively reviewed 81 consecutive patients who underwent DC and subsequent cranioplasty at our institution between January 2015 and December 2019. We then divided the patients into two groups, one not using the silicone elastomer sheet (n = 50) and the other using the silicone elastomer sheet (n = 31), and compared the surgical outcomes. (3) Results: We found that the use of the sheet shortened the operation time by 24% and reduced the estimated blood loss (EBL) by 43% compared to the control group. Moreover, the complication rate of epidural fluid collection (EFC) in the group using the sheet was 16.7%, which was lower than that in the control group (41.7%, p < 0.023). Multivariate logistic regression analysis showed the sheet (OR 0.294, 95% CI 0.093–0.934, p = 0.039) to be significantly related to EFC. (4) Conclusions: The technique using the silicone elastomer sheet allows surgeons to easily dissect the surgical plane during cranioplasty, which shortens the operation time, reduces EBL, and minimizes complications of EFC.

scholarly journals Selective release of a potent anticancer agent from a supramolecular hydrogel using green light

RSC Advances ◽  
2021 ◽  
Vol 11 (15) ◽  
pp. 8546-8551
Author(s):  
Johannes Karcher ◽  
Susanne Kirchner ◽  
Anna-Lena Leistner ◽  
Christian Hald ◽  
Philipp Geng ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Green Light ◽  
Supramolecular Hydrogel ◽  
Triggered Release ◽  
Physiological Conditions

Selective green-light triggered release of an anticancer agent under physiological conditions from a supramolecular hydrogel.

Host–guest interaction-mediated fabrication of a hybrid microsphere-structured supramolecular hydrogel showing high mechanical strength

Soft Matter ◽  
2020 ◽  
Vol 16 (14) ◽  
pp. 3416-3424
Author(s):  
Xiongzhi Zhang ◽  
Yuanxun Liu ◽  
Junwei Wen ◽  
Zhiyong Zhao ◽  
Hongxiang Chen ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Supramolecular Hydrogel ◽  
High Mechanical Strength

The introduction of structured microsphere composites into hydrogels is found to improve their mechanical strength capability.

A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

2021 ◽  
Vol 9 (14) ◽  
pp. 3200-3209
Author(s):  
Wei Ha ◽  
Xiao-Bo Zhao ◽  
Wei-Hua Zhao ◽  
Jiang-Jiang Tang ◽  
Yan-Ping Shi
Keyword(s):  
Self Assembly ◽  
Drug Combination ◽  
Therapeutic Agents ◽  
Supramolecular Hydrogel ◽  
Assembly Strategy ◽  
Hydrogel Formation

An ingeniously designed podophyllotoxin nanoprodrug was synthesized and offered an effective platform for co-delivery of multiple therapeutic agents for drug combination via the hierarchical self-assembly strategy.

Bioinspired self-assembly supramolecular hydrogel for ocular drug delivery

2021 ◽  
Author(s):  
Xianglian Li ◽  
Hui Liu ◽  
Ailing Yu ◽  
Dan Lin ◽  
Zhishu Bao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Ocular Drug Delivery ◽  
Supramolecular Hydrogel

Montmorillonite−Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines

2011 ◽  
Vol 133 (6) ◽  
pp. 1670-1673 ◽  
Author(s):  
Masato Ikeda ◽  
Tatsuyuki Yoshii ◽  
Toshihiro Matsui ◽  
Tatsuya Tanida ◽  
Harunobu Komatsu ◽  
...  
Keyword(s):  
Supramolecular Hydrogel
Sign in / Sign up

Export Citation Format

Share Document