scholarly journals Phospholipase A2 Inhibitor-Loaded Phospholipid Micelles Abolish Neuropathic Pain

ACS Nano ◽  
2020 ◽  
Vol 14 (7) ◽  
pp. 8103-8115
Author(s):  
Sonia Kartha ◽  
Lesan Yan ◽  
Meagan E. Ita ◽  
Ahmad Amirshaghaghi ◽  
Lijun Luo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Phospholipase A2 ◽  
Phospholipid Micelles ◽  
Phospholipase A2 Inhibitor

Subunit structure and inhibition specificity of α-type phospholipase A2 inhibitor from Protobothrops flavoviridis

Toxicon ◽  
2008 ◽  
Vol 51 (5) ◽  
pp. 787-796 ◽  
Author(s):  
Akiko Shimada ◽  
Naoki Ohkura ◽  
Kyozo Hayashi ◽  
Yuji Samejima ◽  
Tamotsu Omori-Satoh ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Subunit Structure ◽  
Phospholipase A2 Inhibitor

Bis(µ-Tartrato)Di(μ-Hydroxy) Germanate (IV) Triethanolammonium as a Mononuclear Alkaline Phospholipase A2 Inhibitor

2021 ◽  
Vol 496 (1) ◽  
pp. 10-13
Author(s):  
P. A. Storozhenko ◽  
M. M. Rasulov ◽  
I. V. Zhigacheva ◽  
V. P. Baryshok
Keyword(s):  
Phospholipase A2 ◽  
Phospholipase A2 Inhibitor

scholarly journals Ca2+-Independent Phospholipase A2 Inhibitor Impairs Spatial Memory of Mice

2000 ◽  
Vol 83 (3) ◽  
pp. 277-278
Author(s):  
Shinichi Fujita ◽  
Yuji Ikegaya ◽  
Nobuyoshi Nishiyama ◽  
Norio Matsuki
Keyword(s):  
Spatial Memory ◽  
Phospholipase A2 ◽  
Phospholipase A2 Inhibitor

Molecular cloning of a γ-phospholipase A2 inhibitor from Lachesis muta muta (the bushmaster snake)

Toxicon ◽  
2003 ◽  
Vol 41 (7) ◽  
pp. 909-917 ◽  
Author(s):  
C.L. Fortes-Dias ◽  
C.J. Barcellos ◽  
M.I. Estevão-Costa
Keyword(s):  
Phospholipase A2 ◽  
Molecular Cloning ◽  
Phospholipase A2 Inhibitor ◽  
Lachesis Muta

Isolation and Fundamental Properties of a Phospholipase A2 Inhibitor from the Blood Plasma of Trimeresurus flavoviridis1

1989 ◽  
Vol 106 (6) ◽  
pp. 966-971 ◽  
Author(s):  
Hiroyuki Kogaki ◽  
Seiji Inoue ◽  
Kiyoshi Ikeda ◽  
Yuji Samejima ◽  
Tamotsu Omori-Satoh ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Blood Plasma ◽  
Fundamental Properties ◽  
Phospholipase A2 Inhibitor

Effects of phospholipase A2, 12-lipoxygenase, and cyclooxygenase inhibitors in the feline pulmonary bed

1997 ◽  
Vol 272 (4) ◽  
pp. L573-L579 ◽  
Author(s):  
A. D. Kaye ◽  
B. D. Nossaman ◽  
D. E. Smith ◽  
I. N. Ibrahim ◽  
J. D. Imig ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Phospholipase C ◽  
Bay K 8644 ◽  
Cyclooxygenase Inhibitors ◽  
Ang Ii ◽  
Lipoxygenase Inhibitor ◽  
Arterial Perfusion ◽  
Vascular Bed ◽  
Phospholipase A2 Inhibitor ◽  
Pulmonary Vascular Bed

The effects of phosphonofluoridic acid, methyl-5,8,11,14-eicosatetraenyl ester (MAFP), a phospholipase A2 inhibitor, on pressor responses to angiotensin II (ANG II), norepinephrine (NE), serotonin (5-HT), the calcium channel opener BAY K 8644, and the thromboxane A2 mimic U-46619 were studied in the pulmonary vascular bed of the intact-chest cat. Under conditions of constant lobar blood flow, injections of ANG II, NE, 5-HT, U-46619, and BAY K 8644 into the lobar arterial perfusion circuit caused dose-related increases in lobar arterial pressure that were reproducible with respect to time. Infusion of MAFP into the perfused lobar artery at doses of 100 to 300 microg/kg for 10 min significantly reduced vasoconstrictor responses to ANG II; however, the phospholipase A2 inhibitor did not alter vasoconstrictor responses to BAY K 8644, 5-HT, NE, or U-46619. The combination of the higher dose of the phospholipase A2 inhibitor MAFP with the phospholipase C inhibitor U-73122 significantly affected vasoconstrictor responses to ANG II, NE, and 5-HT but not to BAY K 8644. In a separate series of animals, the effects of a lipoxygenase inhibitor, baicalein, were investigated. Infusion of baicalein into the perfused lobar artery at doses of 100 microg/kg for 10 min significantly reduced vasoconstrictor responses to ANG II but not the vasoconstrictor responses to BAY K 8644, 5-HT, NE, or U-46619. In a final series of experiments, the effects of a cyclooxygenase inhibitor, meclofenamate, were investigated, and intravenous injection of the meclofenamate at a dose of 2.5 mg/kg did not significantly affect vasoconstrictor responses to ANG II, 5-HT, BAY K 8644, NE, or U-46619. These data provide support for the hypothesis that pulmonary vasopressor responses to ANG II are mediated, in part, by the activation of phospholipase A2, phospholipase C, and the lipoxygenase pathway in the pulmonary vascular bed of the cat.

Investigation of the inhibitory potential of phospholipase A2 inhibitor gamma from Sinonatrix annularis to snake envenomation

Toxicon ◽  
2017 ◽  
Vol 137 ◽  
pp. 83-91 ◽  
Author(s):  
Shengwei Xiong ◽  
Yunyun Luo ◽  
Lipeng Zhong ◽  
Huixiang Xiao ◽  
Hong Pan ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Envenomation ◽  
Phospholipase A2 Inhibitor ◽  
Inhibitory Potential
Sign in / Sign up

Export Citation Format

Share Document