Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy

ACS Nano ◽  
2020 ◽  
Vol 14 (7) ◽  
pp. 8074-8083 ◽  
Author(s):  
Zhuo Liu ◽  
Lingling Xu ◽  
Qiang Zheng ◽  
Yong Kang ◽  
Bojing Shi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Human Motion ◽  
Self Powered

scholarly journals An Effective Self-Powered Piezoelectric Sensor for Monitoring Basketball Skills

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5144
Author(s):  
Chongle Zhao ◽  
Changjun Jia ◽  
Yongsheng Zhu ◽  
Tianming Zhao
Keyword(s):  
Control Function ◽  
Mechanical Energy ◽  
Active Material ◽  
Piezoelectric Sensor ◽  
Human Motion ◽  
Flexible Sensors ◽  
External Power ◽  
Point Control ◽  
Self Powered

Self-powered piezoelectric sensor can achieve real-time and harmless monitoring of motion processes without external power supply, which can be attached on body skin or joints to detect human motion and powered by mechanical energy. Here, a sensor for monitoring emergent motion is developed using the PVDF as active material and piezoelectric output as sensing signal. The multi-point control function enables the sensor to monitor the sequence of force order, angle change, and motion frequency of the “elbow lift, arm extension, and wrist compression” during shooting basketball. In addition, the sensor shows can simultaneously charge the capacitor to provide more power for intelligence, typically Bluetooth transmission. The sensor shows good performance in other field, such as rehabilitation monitoring and speech input systems. Therefore, the emerging application of flexible sensors have huge long-term prospects in sport big data collection and Internet of Things (IoT).

Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov
Keyword(s):  
Drug Delivery ◽  
Survival Rate ◽  
Cancer Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Patient Survival ◽  
Focal Therapy ◽  
Local Drug Delivery ◽  
Large Size ◽  
Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

scholarly journals EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Wang ◽  
Jiangyong Miao ◽  
Lina Wang ◽  
Ying Liu ◽  
Hui Ji ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Cancer Therapy ◽  
Acute Ischemic Stroke ◽  
Oral Anticoagulants ◽  
Initial Manifestation ◽  
Arterial Thromboembolism ◽  
Systemic Embolization ◽  
Effective Cancer Therapy

Abstract Background Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established. Case presentation We described a case of Trousseau’s syndrome resulting in acute ischemic stroke concomitant with multiple embolizations in the spleen and kidney during oral administration of dabigatran for pulmonary embolism preceding the diagnosis of a malignant tumor. A cancer-related hypercoagulable state was suspected because the patient was admitted to the neurology department due to acute ischemic stroke with three territory infarcts on diffusion-weighted imaging (DWI) in the absence of identifiable conventional risk factors and brain vessel narrowing. The patient was subsequently diagnosed with epidermal growth factor receptor (EGFR) mutation–positive non-small-cell lung cancer (NSCLC) (stage IV) with pleural metastasis. Administration of low-molecular-weight heparin followed by long-term dabigatran under effective cancer therapy comprising gefitinib and subsequent chemotherapy did not cause stroke relapse during the 1-year follow-up. Conclusions This case suggests that cancer-related hypercoagulability should be considered an important etiology for stroke patients who develop unexplained disseminated acute cerebral infarction without conventional stroke risk factors, especially concomitant with multiple organ embolization. Novel oral anticoagulants may be an alternative therapy for the long-term management of cancer-related arterial thromboembolism under effective cancer therapy.

Long-term sequelae after cancer therapy

2004 ◽  
Vol 43 (2) ◽  
pp. 134-141 ◽  
Author(s):  
Sophie Fosså
Keyword(s):  
Cancer Therapy ◽  
After Cancer

Abstract 17468: Left Ventricular Remodeling Index (LVRI) in patients after breast cancer therapy in the long-term follow-up

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Felix Heggemann ◽  
Hanna Buggisch ◽  
Grit Welzel ◽  
Christina Doesch ◽  
Jochen Hansmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Radiation Dose ◽  
Ventricular Remodeling ◽  
Left Ventricular ◽  
High Dose ◽  
Breast Cancer Therapy ◽  
Additional Chemotherapy ◽  
Whole Heart

Introduction: Cardiotoxic side effects are of concern in long-term survivors of left-sided breast cancer therapy. 3-dimensional conventional radiotherapy (3DCRT) deposits high doses in defined regions of the heart. Intensity modulated radiotherapy (IMRT) reduces local high-dose exposition at the expense of exposing more heart tissue to lower doses. Cardio-MRI was performed in this study to assess MRI-morphologic and functional alterations after 3DCRT and IMRT/ additional chemotherapy, with IMRT only performed in patients that would have been exposed to unacceptably high heart doses with 3DCRT. Methods: 49 patients with left-sided breast cancer (38 3DCRT and 11 IMRT; 20 patients with additional adjuvant chemotherapy (ACH) (13 3DCRT, 7 IMRT) were included prospectively. Baseline (pre-treatment) and 24 months post-treatment MRI was performed. With MRI, enddiastolic left ventricular mass (LVM), enddiastolic left ventricular volume (LVEDV) and stroke volume (SV) were assessed. LVRI was calculated with the formula LVM/LVEDV. Results: Mean dose for the whole heart was higher in IMRT than in 3DCRT patients (12.9±3.9 vs. 4.5 ±2.4 Gy). Larger regions received a higher radiation dose (>40Gy) in 3DCRT than in IMRT patients (3.3% vs. 1.3% of the whole heart). High local radiation dose > 50 Gy only occurred in the 3DCRT group (0.74% of the heart volume). After 24 months LVRI decreased significantly in patients with ACH (0.80 vs. 0.70, p=0.028). Non-significant decrease of LVRI was observed in the whole cohort (0.85 vs. 0.79), after IMRT (0.74 vs. 0.71), after 3DCRT (0.88 vs. 0.82) and without ACH (0.87 vs. 0.84). Decrease of LVRI in patients with ACH was caused by significant decrease of LVM (102.4 vs. 89.7 g, p=0.028) whereas LVEDV was stable (128.3 vs. 128.1g). In all groups, no significant decrease of SV could be assessed after 24 months. Conclusions: 24 months after therapy, significant decrease of LVRI due to decreased LVM could be found only in patients with additional chemotherapy. Radiotherapy alone did not have a significant impact on LVRI, LVM and SV. Low doses to the whole heart with IMRT did not cause significant decreases in LVRI, LVM and SV. LVM and LVRI are to be assessed in larger cohorts in patients with cancer therapy especially with additional chemotherapy.

Long-Term Effects of Childhood Cancer Therapy on Growth and Fertility

2016 ◽  
pp. 657-670 ◽  
Author(s):  
Michelle Reece-Mills ◽  
Louise E. Bath ◽  
Christopher J. Kelnar ◽  
Hamish B. Wallace ◽  
Charles Keys ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Childhood Cancer ◽  
Long Term Effects

scholarly journals Vibration Bandgaps of Piezoelectric Metamaterial Plate with Local Resonators for Vibration Energy Harvesting

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Zhongsheng Chen ◽  
Jing He ◽  
Gang Wang
Keyword(s):  
Energy Harvesting ◽  
Plate Theory ◽  
Ritz Method ◽  
Low Frequency ◽  
Structural Vibration ◽  
Vibration Energy ◽  
Vibration Energy Harvesting ◽  
Bottle Neck ◽  
Self Powered

Embedded wireless sensing networks (WSNs) provide effective solutions for structural health monitoring (SHM), where how to provide long-term electric power is a bottle-neck problem. Piezoelectric vibration energy harvesting (PVEH) has been widely studied to realize self-powered WSNs due to piezoelectric effect. Structural vibrations are usually variable and exist in the form of elastic waves, so cantilever-like harvesters are not appropriate. In this paper, one kind of two-dimensional (2D) piezoelectric metamaterial plates with local resonators (PMP-LR) is investigated for structural vibration energy harvesting. In order to achieve low-frequency and broadband PVEH in SHM, it is highly necessary to study dynamic characteristics of PMP-LR, particularly bandgaps. Firstly, an analytical model is developed based on the Kirchhoff plate theory, and modal analysis is done by using the Rayleigh–Ritz method. Then, effects of geometric and material parameters on vibration bandgaps are analyzed by finite element-based simulations. In the end, experiments are carried out to validate the simulated results. The results demonstrate that the location of bandgaps can be easily adjusted by the design of local resonators. Therefore, the proposed method will provide an effective tool for optimizing local resonators in PMP-LR.

The oral management of oncology patients requiring radiotherapy, chemotherapy and/or bone marrow transplantation

2013 ◽  
Vol 4 (4) ◽  
pp. 200-203 ◽  
Author(s):  
Navdeep Kumar ◽  
Anthony Brooke ◽  
Mary Burke ◽  
Rebecca John ◽  
Amanda O’Donnell ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cancer Therapy ◽  
Clinical Guideline ◽  
Oral Care ◽  
Oncology Patients ◽  
Executive Summary ◽  
Short And Long Term ◽  
After Cancer

Patients undergoing cancer therapy may experience unwanted side-effects involving the oral cavity and more evidence is emerging regarding the management of these complications. These oral effects have both short and long-term implications. Dentists need to be aware of these implications and liaise closely with the oncology teams to establish pathways of oral care. This enables patients to have appropriate dental support in place before, during and after cancer therapy. This article is an executive summary of a review undertaken for a national clinical guideline, The Oral Management of Oncology Patients following Radiotherapy, Chemotherapy and/or Bone Marrow Transplanation. The full text is available on the FDS website: www.rcseng.ac.uk/fds/publications-clinical-guidelines/clinical_guidelines/

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