scholarly journals Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

2020 ◽  
Vol 15 (3) ◽  
pp. 657-668 ◽  
Author(s):  
Matthias R. Bauer ◽  
Andreas Krämer ◽  
Giovanni Settanni ◽  
Rhiannon N. Jones ◽  
Xiaomin Ni ◽  
...  
Keyword(s):  
Small Molecule ◽  
Cancer Mutations

scholarly journals Insights into cancer severity from biomolecular interaction mechanisms

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Francesco Raimondi ◽  
Gurdeep Singh ◽  
Matthew J. Betts ◽  
Gordana Apic ◽  
Ranka Vukotic ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
High Throughput Sequencing ◽  
Somatic Mutations ◽  
Interaction Data ◽  
Cancer Genes ◽  
Histological Subtypes ◽  
Biomolecular Interaction ◽  
Cancer Mutations ◽  
Molecule Interactions

Abstract To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has identified thousands of somatic mutations across dozens of cancers, and there is a pressing need to identify the few that are pathologically relevant. Here we use protein structure and interaction data to interrogate nonsynonymous somatic cancer mutations, identifying a set of 213 molecular interfaces (protein-protein, -small molecule or –nucleic acid) most often perturbed in cancer, highlighting several potentially novel cancer genes. Over half of these interfaces involve protein-small-molecule interactions highlighting their overall importance in cancer. We found distinct differences in the predominance of perturbed interfaces between cancers and histological subtypes and presence or absence of certain interfaces appears to correlate with cancer severity.

A privileged ternary blend enabling non-fullerene organic photovoltaics with over 14% efficiency

2020 ◽  
Vol 8 (43) ◽  
pp. 15135-15141
Author(s):  
Jing Yan ◽  
Yuan-Qiu-Qiang Yi ◽  
Jianqi Zhang ◽  
Huanran Feng ◽  
Yanfeng Ma ◽  
...  
Keyword(s):  
Small Molecule ◽  
Organic Photovoltaics ◽  
Power Conversion ◽  
Ternary Blend ◽  
Conversion Efficiencies

Two non-fullerene small molecule acceptors, NT-4F and NT-4Cl, were designed and synthesized. Power conversion efficiencies of 11.44% and 14.55% were achieved for NT-4Cl-based binary and ternary devices, respectively.

The small-molecule antibiotics pipeline: 2014–2018

2019 ◽  
Vol 18 (10) ◽  
pp. 739-739 ◽  
Author(s):  
Cara Lepore ◽  
Lynn Silver ◽  
Ursula Theuretzbacher ◽  
Joe Thomas ◽  
David Visi
Keyword(s):  
Small Molecule

Anisotropic forces in small molecule crystals

1985 ◽  
Vol 82 ◽  
pp. 91-97 ◽  
Author(s):  
H. Bonadeo ◽  
E. Burgos
Keyword(s):  
Small Molecule

P157 FBXO3-FBXL2 AXIS MODULATORS AS A NOVEL CLASS OF ORAL SMALL MOLECULE COMPOUNDS FOR THE TREATMENT OF CROHN’S DISEASE

2020 ◽  
Vol 158 (3) ◽  
pp. S9-S10
Author(s):  
Franca Angeli ◽  
Russell Wyborski ◽  
Bill Chen ◽  
Rama Mallampalli ◽  
Michael Lark
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Small Molecule

Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor
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