scholarly journals Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers that Bind HIV-1 Integrase with Picomolar Affinity

2019 ◽  
Author(s):  
Kevin M. Rose ◽  
Irani Alves Ferreira-Bravo ◽  
Min Li ◽  
Robert Craigie ◽  
Mark A Ditzler ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Hiv 1 ◽  
Selection Of

scholarly journals Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3821
Author(s):  
Rita Meleddu ◽  
Angela Corona ◽  
Simona Distinto ◽  
Filippo Cottiglia ◽  
Serenella Deplano ◽  
...  
Keyword(s):  
Single Agent ◽  
Hiv Reverse Transcriptase ◽  
Substitution Pattern ◽  
Associated Functions ◽  
Dual Inhibition ◽  
Hiv Rt ◽  
Therapeutic Protocols ◽  
Anti Hiv ◽  
Hiv 1 ◽  
Selection Of

Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for the use of lower doses of each single agent to reduce toxicity. However, avoiding drugs interactions and patient compliance are issues not fully accomplished so far. Pursuing on our investigation on potential anti HIV multi-target agents we have designed and synthesized a small library of biphenylhydrazo 4-arylthiazoles derivatives and evaluated to investigate the ability of the new derivatives to simultaneously inhibit both associated functions of HIV reverse transcriptase. All compounds were active towards the two functions, although at different concentrations. The substitution pattern on the biphenyl moiety appears relevant to determine the activity. In particular, compound 2-{3-[(2-{4-[4-(hydroxynitroso)phenyl]-1,3-thiazol-2-yl} hydrazin-1-ylidene) methyl]-4-methoxyphenyl} benzamide bromide (EMAC2063) was the most potent towards RNaseH (IC50 = 4.5 mM)- and RDDP (IC50 = 8.0 mM) HIV RT-associated functions.

scholarly journals Signature Nucleotide Polymorphisms at Positions 64 and 65 in Reverse Transcriptase Favor the Selection of the K65R Resistance Mutation in HIV‐1 Subtype C

2009 ◽  
Vol 200 (8) ◽  
pp. 1202-1206 ◽  
Author(s):  
Cédric F. Invernizzi ◽  
Dimitrios Coutsinos ◽  
Maureen Oliveira ◽  
Daniela Moisi ◽  
Bluma G. Brenner ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Resistance Mutation ◽  
Nucleotide Polymorphisms ◽  
Subtype C ◽  
Hiv 1 ◽  
Selection Of

scholarly journals A non-cleavable hexahistidine affinity tag at the carboxyl-terminus of the HIV-1 Pr55Gag polyprotein alters nucleic acid binding properties

2017 ◽  
Vol 130 ◽  
pp. 137-145 ◽  
Author(s):  
Maria C. Bewley ◽  
Lisa Reinhart ◽  
Matthew S. Stake ◽  
Shorena Nadaraia-Hoke ◽  
Leslie J. Parent ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Carboxyl Terminus ◽  
Nucleic Acid Binding ◽  
Affinity Tag ◽  
Binding Properties ◽  
Hiv 1

scholarly journals Risk Minimization Measures for Blood Screening HIV-1 Nucleic Acid Amplification Technique Assays in Germany

2014 ◽  
Vol 41 (1) ◽  
pp. 8-8 ◽  
Author(s):  
Michael Chudy ◽  
Julia Kress ◽  
Jochen Halbauer ◽  
Margarethe Heiden ◽  
Markus B. Funk ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Amplification ◽  
Risk Minimization ◽  
Amplification Technique ◽  
Hiv 1 ◽  
Nucleic Acid Amplification Technique ◽  
Blood Screening

Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity

2002 ◽  
Vol 296 (5) ◽  
pp. 1228-1237 ◽  
Author(s):  
Andrew G Stephen ◽  
Karen M Worthy ◽  
Eric Towler ◽  
Judy A Mikovits ◽  
Shizuko Sei ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Protein Nucleic Acid ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

2011 ◽  
Vol 7 (2) ◽  
pp. e1001273 ◽  
Author(s):  
Guido Ferrari ◽  
Bette Korber ◽  
Nilu Goonetilleke ◽  
Michael K. P. Liu ◽  
Emma L. Turnbull ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Functional Profile ◽  
Escape Mutants ◽  
Acute Hiv ◽  
Hiv 1 ◽  
Selection Of

Rationally Designed Peptides as Efficient Inhibitors of Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein

Biochemistry ◽  
2018 ◽  
Vol 57 (30) ◽  
pp. 4562-4573 ◽  
Author(s):  
Volodymyr Shvadchak ◽  
Sarwat Zgheib ◽  
Beata Basta ◽  
Nicolas Humbert ◽  
Johannes Langedijk ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Chaperone Activity ◽  
Nucleic Acid Chaperone ◽  
Hiv 1
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