Parathyroid Hormone Senses Extracellular Calcium To Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor

2018 ◽  
Vol 13 (8) ◽  
pp. 2347-2358 ◽  
Author(s):  
Kelly J. Culhane ◽  
Morgan E. Belina ◽  
Jeremiah N. Sims ◽  
Yingying Cai ◽  
Yuting Liu ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Extracellular Calcium ◽  
The Family ◽  
Parathyroid Hormone 1 Receptor ◽  
Endocrine Signaling

Fragmented Adipose Tissue Transplanted to Craniofacial Deformities Induces Bone Repair Associated with Immunoexpression of Adiponectin and Parathyroid Hormone 1-Receptor

2013 ◽  
Vol 50 (6) ◽  
pp. 639-647 ◽  
Author(s):  
Ranulfo Duarte Azevedo-Neto ◽  
Carla Castiglia Gonzaga ◽  
Tatiana Miranda Deliberador ◽  
Luiz Gustavo Klug ◽  
Lidiane Da Costa Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Parathyroid Hormone ◽  
Bone Repair ◽  
Parathyroid Hormone 1 Receptor

scholarly journals Small Molecule Inhibition of the Na+/H+ Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction

Biochemistry ◽  
2014 ◽  
Vol 53 (37) ◽  
pp. 5916-5922 ◽  
Author(s):  
Jeremy M. Fitzpatrick ◽  
Maria Pellegrini ◽  
Patrick R. Cushing ◽  
Dale F. Mierke
Keyword(s):  
Parathyroid Hormone ◽  
Small Molecule ◽  
Receptor Interaction ◽  
Regulatory Factor ◽  
Small Molecule Inhibition ◽  
Parathyroid Hormone 1 Receptor

scholarly journals The Parathyroid Hormone and Peptides Like It. Literature Review

2019 ◽  
Vol 74 (2) ◽  
pp. 136-144 ◽  
Author(s):  
Natalia G. Mokrysheva ◽  
Julia A. Krupinova ◽  
Elena V. Kovaleva
Keyword(s):  
Parathyroid Hormone ◽  
Phosphate Homeostasis ◽  
Amino Terminal ◽  
New Methods ◽  
Parathyroid Hormone Related Protein ◽  
Wide Range ◽  
The Family ◽  
Genes Encoding ◽  
Tuberoinfundibular Peptide ◽  
Homologous Amino Acid

Wide prevalence of the parathyroid glands pathology and the need for new methods of diagnosis and treatment are forcing researchers all over the world to go more deeply into the pathophysiological mechanisms. A parathyroid hormone (PTH) is main cause of mineral disorders. In addition, humans have a family with similar in structure molecules that contribute to the maintenance of calcium and phosphate homeostasis. The family includes PTH, parathyroid hormone-related protein (PTHrP) and tuberoinfundibular peptide 39 (TIP39, also known as PTH2). The genes encoding these peptides have highly homologous amino acid regions in the N-(amino) terminal receptor-binding sites of each family member, as well as the preserved structure of their organization, which seems to be due to the presence of one parent gene. The variety of classical and “non-classical” effects allows to expand the understanding of these substances and consider them as hormones that go beyond the regulation of phosphorus-calcium metabolism. The review provides information on the structure and biosynthesis of these peptides, as well as a wide range of their effects on the human body.

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