scholarly journals A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing

2017 ◽  
Vol 12 (6) ◽  
pp. 1611-1620 ◽  
Author(s):  
Matthew D. Shortridge ◽  
Matthew J. Walker ◽  
Tom Pavelitz ◽  
Yu Chen ◽  
Wen Yang ◽  
...  
Keyword(s):  
Peptide Ligand ◽  
Macrocyclic Peptide

scholarly journals Epitope-Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin-17F

2018 ◽  
Vol 24 (15) ◽  
pp. 3760-3767 ◽  
Author(s):  
Bert T. Lai ◽  
Jeré A. Wilson ◽  
Jacquie Malette Loredo ◽  
Suresh M. Pitram ◽  
Nicole A. LaBerge ◽  
...  
Keyword(s):  
Peptide Ligand ◽  
Cooperative Binding ◽  
Macrocyclic Peptide ◽  
Interleukin 17F

PART III. AutoimmunityAn Altered Peptide Ligand of Type II Collagen Suppresses Autoimmune Arthritis

2007 ◽  
Vol 27 (4) ◽  
pp. 345-356 ◽  
Author(s):  
Linda K. Myers ◽  
Bo Tang ◽  
Edward F. Rosioniec ◽  
John M. Stuart ◽  
Andrew H. Kang
Keyword(s):  
Type Ii Collagen ◽  
Peptide Ligand ◽  
Autoimmune Arthritis ◽  
Altered Peptide Ligand ◽  
Type Ii

scholarly journals Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles

2021 ◽  
Author(s):  
Sebastian Dengler ◽  
Pradeep Kumar Mandal ◽  
Lars Allmendinger ◽  
Céline Douat ◽  
Ivan Huc
Keyword(s):  
Important Class ◽  
Hybrid Peptide ◽  
Bioactive Substances ◽  
Macrocyclic Peptides ◽  
Macrocyclic Peptide

Macrocyclic peptides are an important class of bioactive substances. When inserting an aromatic foldamer segment in a macrocyclic peptide, the strong folding propensity of the former may influence the conformation...

scholarly journals Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Douglas MacPherson ◽  
Yaron Bram ◽  
Jiwoon Park ◽  
Robert E. Schwartz
Keyword(s):  
Cytochrome P450 ◽  
Human Hepatocytes ◽  
Peptide Ligand ◽  
3D Scaffold ◽  
Primary Human Hepatocytes ◽  
Peptide Component ◽  
Functional Peptide ◽  
Arginine Glycine Aspartic Acid ◽  
And Function ◽  
Cooperative Assembly

AbstractWe report here the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes. The system is based on the cooperative assembly of a fiber-forming peptide component, fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF), and the integrin-binding functional peptide ligand, Fmoc-arginine-glycine-aspartic acid (Fmoc-RGD) into a nanofibrous gel at physiological pH. This Fmoc-FF/RGD hydrogel was formulated to provide a biomimetic microenvironment with some critical features such as mechanical properties and nanofiber morphology, which were optimized to support hepatocyte culture. The material was shown to support maintenance and function of encapsulated primary human hepatocytes as indicated by actin staining, qRT-PCR, and functional cytochrome P450 assays. The designed gel was shown to outperform Matrigel in cytochrome P450 functional assays. The hydrogel may prove useful for liver development and disease models, as well as providing insights into the design of future implantable scaffolds for the regeneration of liver tissue in patients with liver disease.

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