scholarly journals Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

2015 ◽  
Vol 10 (9) ◽  
pp. 2087-2098 ◽  
Author(s):  
Hyunbeom Lee ◽  
Hoang V. Le ◽  
Rui Wu ◽  
Emma Doud ◽  
Ruslan Sanishvili ◽  
...  
Keyword(s):  
Gaba Aminotransferase

GABA-aminotransferase, a target for antiepileptic drug therapy

2000 ◽  
pp. 315-318
Author(s):  
Paola Storici ◽  
Guido Capitani ◽  
Daniela De Biase ◽  
Robert A. John ◽  
Johan N. Jansonius ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Gaba Aminotransferase ◽  
Antiepileptic Drug Therapy

scholarly journals The Rhizobium leguminosarum bv. viciae VF39 γ-aminobutyrate (GABA) aminotransferase gene (gabT) is induced by GABA and highly expressed in bacteroids The GenBank accession number for the sequence determined in this work is AF335502.

Microbiology ◽  
2002 ◽  
Vol 148 (2) ◽  
pp. 615-623 ◽  
Author(s):  
Jürgen Prell ◽  
Bert Boesten ◽  
Philip Poole ◽  
Ursula B Priefer
Keyword(s):  
Rhizobium Leguminosarum ◽  
Free Living ◽  
Carbon And Nitrogen ◽  
Gaba Aminotransferase ◽  
Gaba Metabolism ◽  
Promoter Probe ◽  
Promoter Probe Vector ◽  
Oxoglutarate Dehydrogenase ◽  
Substrate Specifities ◽  
Free Living Conditions

A Rhizobium leguminosarum bv. viciae VF39 gene (gabT) encoding a γ-aminobutyrate (GABA) aminotransferase was identified, cloned and characterized. This gene is thought to be involved in GABA metabolism via the GABA shunt pathway, a theoretical bypass of the 2-oxoglutarate dehydrogenase complex. Mutants in gabT are still able to grow on GABA as a sole carbon and nitrogen source. 2-Oxoglutarate-dependent GABA aminotransferase activity is absent in these mutants, while pyruvate-dependent activity remains unaffected. This indicates that at least two enzymes with different substrate specifities are involved in the GABA metabolism of R. leguminosarum bv. viciae VF39. The gabT promoter was cloned into a newly constructed, stable promoter-probe vector pJP2, suitable for the study of transcriptional GUS fusions in free-living bacteria and during symbiosis. Under free-living conditions the gabT promoter is induced by GABA and repressed by succinate. Transcriptional regulation is mediated by GabR in a repressor-like manner. During symbiosis with the pea host plant gabT is induced and highly expressed in the symbiotic zone. Nodules induced by gabT mutants, however, are still effective in nitrogen fixation.

Oxidation of N-nitroethylenediamine, a GABA analog from Agaricussilvaticus, by GABA aminotransferase

1981 ◽  
Vol 103 (3) ◽  
pp. 1077-1082 ◽  
Author(s):  
Theodore A. Alston ◽  
David J.T. Porter ◽  
Steven P. Seitz ◽  
Harold J. Bright
Keyword(s):  
Gaba Aminotransferase
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