scholarly journals Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis

2021 ◽  
Author(s):  
Thibault Annaval ◽  
Christiana N. Teijaro ◽  
Ajeeth Adhikari ◽  
Xiaohui Yan ◽  
Jian-Jun Chen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Hydroxylase

scholarly journals Role of Cytochrome P450 Hydroxylase in the Decreased Accumulation of Vitamin E in Muscle from Turkeys Compared to that from Chickens

2016 ◽  
Vol 64 (3) ◽  
pp. 671-680 ◽  
Author(s):  
Dale M. Perez ◽  
Mark P. Richards ◽  
Robert S. Parker ◽  
Mark E. Berres ◽  
Aaron T. Wright ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Vitamin E ◽  
Cytochrome P450 Hydroxylase

Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine

2014 ◽  
Vol 56 (10) ◽  
pp. 979-994 ◽  
Author(s):  
Xijia Yang ◽  
Di Wu ◽  
Jianxin Shi ◽  
Yi He ◽  
Franck Pinot ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Pollen Exine ◽  
Cytochrome P450 Hydroxylase ◽  
Anther Cuticle

scholarly journals The induction of guerin's carcinoma cytochrome P450 hydroxylase activity by retinoids

2012 ◽  
Vol 58 (5) ◽  
pp. 539-548
Author(s):  
I.A. Shmarakov ◽  
N.V. Katan
Keyword(s):  
Cytochrome P450 ◽  
Vitamin A ◽  
Tumor Growth ◽  
The Body ◽  
Dependent Manner ◽  
Liposomal Form ◽  
Cytochrome P450 Hydroxylase ◽  
All Trans Retinoic Acid ◽  
Guerin’S Carcinoma ◽  
Dose Dependent

The interconnection of tumor growth process and the provision of the body with vitamin A was studied. The replenishment of vitamin A stores of vitamin-deficient tumor bearing animals modulated Guerin's carcinoma growth rate in a dose dependent manner (r=0,83). The morphological parameters of tumor growth at different provision with vitamin A positively correlated with hydroxylase (r=0,81) and demethylase (r=0,49) activities of the Guerin's carcinoma cytochrome P450 system. The induction of hydroxylase and demethylase activities of cytochrome P450 in Guerin's carcinoma microsomal fraction, observed either under conditions of overdose supplementation, or selective liposomal form of all-trans-retinoic acid, suggests the stimulatory effect of retinoids on tumor growth.

scholarly journals Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis

Endocrinology ◽  
2006 ◽  
Vol 147 (1) ◽  
pp. 96-110 ◽  
Author(s):  
Nadège Vernet ◽  
Christine Dennefeld ◽  
Cécile Rochette-Egly ◽  
Mustapha Oulad-Abdelghani ◽  
Pierre Chambon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Retinoic Acid ◽  
Vitamin A ◽  
Signaling Pathways ◽  
Sertoli Cells ◽  
Vitamin A Deficiency ◽  
Expression Patterns ◽  
Mouse Testis ◽  
Cytochrome P450 Hydroxylase ◽  
Lecithin:Retinol Acyltransferase

As a first step in investigating the role of retinoic acid (RA) in mouse testis, we analyzed the distribution pattern of the enzymes involved in vitamin A storage (lecithin:retinol acyltransferase), RA synthesis (β-carotene 15,15′-monoxygenase and retinaldehyde dehydrogenases) and RA degradation (cytochrome P450 hydroxylases) as well as those of all isotypes of receptors transducing the RA signal [RA receptors (RARs) and rexinoid receptors (RXRs)]. Our data indicate that in adult testis 1) cytochrome P450 hydroxylase enzymes may generate in peritubular myoid cells a catabolic barrier that prevents circulating RA and RA synthesized by Leydig cells to enter the seminiferous epithelium; 2) the compartmentalization of RA synthesis within this epithelium may modulate, through paracrine mechanisms, the coupling between spermatogonia proliferation and spermatogenesis; 3) retinyl esters synthesized in round spermatids by lecithin:retinol acyltransferase may be transferred and stored in Sertoli cells, in the form of adipose differentiation-related protein-coated lipid droplets. We also show that RARα and RXRβ are confined to Sertoli cells, whereas RARγ is expressed in spermatogonia and RARβ, RXRα, and RXRγ are colocalized in step 7–8 spermatids. Correlating these expression patterns with the pathological phenotypes generated in response to RAR and RXR mutations and to postnatal vitamin A deficiency suggests that spermiation requires RXRβ/RARα heterodimers in Sertoli cells, whereas spermatogonia proliferation involves, independently of RXR, two distinct RAR-mediated signaling pathways in both Sertoli cells and spermatogonia. Our data also suggest that the involvement of RA in testis development starts when primary spermatogonia first appear.

Astaxanthin accumulation in Haematococcus requires a cytochrome P450 hydroxylase and an active synthesis of fatty acids

FEBS Letters ◽  
2001 ◽  
Vol 500 (3) ◽  
pp. 125-128 ◽  
Author(s):  
Benoı̂t Schoefs ◽  
Nour-Eddine Rmiki ◽  
Jaouad Rachadi ◽  
Yves Lemoine
Keyword(s):  
Fatty Acids ◽  
Cytochrome P450 ◽  
Active Synthesis ◽  
Cytochrome P450 Hydroxylase
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