scholarly journals Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A

2021 ◽  
Author(s):  
James E. Longbotham ◽  
Mark J. S. Kelly ◽  
Danica Galonić Fujimori
Keyword(s):  
Histone H3 ◽  
Histone Demethylase ◽  
Histone H3 Methylation

scholarly journals Apoptotic mechanisms of gastric cancer cells induced by isolated Erinacine S through epigenetic histone H3 methylation of FasL and TRAIL

2021 ◽  
Author(s):  
Hsing-Chun Kuo ◽  
Shui-Yi Tung ◽  
Ko-Chao Lee ◽  
Kam-Fai Lee ◽  
Ya-Ling Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Histone H3 ◽  
Ethanol Extract ◽  
Gastric Cancer Cells ◽  
Hericium Erinaceus ◽  
Histone H3 Methylation ◽  
Health Promoting ◽  
Great Health

Erinacine S, the new bioactive diterpenoid compound isolated from the ethanol extract of the mycelia of Hericium erinaceus, displays great health-promoting properties. However, the effects of erinacine S on inductive...

scholarly journals Drosophila UTX Is a Histone H3 Lys27 Demethylase That Colocalizes with the Elongating Form of RNA Polymerase II

2007 ◽  
Vol 28 (3) ◽  
pp. 1041-1046 ◽  
Author(s):  
Edwin R. Smith ◽  
Min Gyu Lee ◽  
Benjamin Winter ◽  
Nathan M. Droz ◽  
Joel C. Eissenberg ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Histone H3 ◽  
Silent Chromatin ◽  
H3k4 Methylation ◽  
Active Chromatin ◽  
Pol Ii ◽  
H3k27 Methylation ◽  
Histone H3 Methylation ◽  
Heat Shock Induction

ABSTRACT Histone H3 methylation at Lys27 (H3K27 methylation) is a hallmark of silent chromatin, while H3K4 methylation is associated with active chromatin regions. Here we report that a Drosophila JmjC family member, dUTX, specifically demethylates di- and trimethylated but not monomethylated H3K27. dUTX localization on chromatin correlates with the elongating form of RNA polymerase II (Pol II), and dUTX can associate with Pol II. Furthermore, heat shock induction results in the recruitment of dUTX to the hsp70 gene, like that of several other Pol II elongation factors. Our data indicate that dUTX is intimately associated with actively transcribed genes and may provide a paradigm for how H3K27 demethylation is required for the activation of preinitiated Pol II on transcriptionally poised genes.

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