scholarly journals Nuclear Receptor Chemical Reporter Enables Domain-Specific Analysis of Ligands in Mammalian Cells

2020 ◽  
Vol 15 (9) ◽  
pp. 2324-2330
Author(s):  
Taku Tsukidate ◽  
Qiang Li ◽  
Howard C. Hang
Keyword(s):  
Nuclear Receptor ◽  
Mammalian Cells ◽  
Domain Specific ◽  
Specific Analysis ◽  
Chemical Reporter

scholarly journals A domain-specific analysis system for examining nuclear reactor simulation data for light-water and sodium-cooled fast reactors

2015 ◽  
Vol 85 ◽  
pp. 856-868 ◽  
Author(s):  
Jay Jay Billings ◽  
Jordan H. Deyton ◽  
S. Forest Hull ◽  
Eric J. Lingerfelt ◽  
Anna Wojtowicz
Keyword(s):  
Nuclear Reactor ◽  
Fast Reactors ◽  
Simulation Data ◽  
Light Water ◽  
Domain Specific ◽  
Specific Analysis ◽  
Analysis System

scholarly journals The Metabolic Chemical Reporter Ac46AzGal Could Incorporate Intracellular Protein Modification in the Form of UDP-6AzGlc Mediated by OGT and Enzymes in the Leloir Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Jiajia Wang ◽  
Biao Dou ◽  
Lu Zheng ◽  
Wei Cao ◽  
Peiyu Dong ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Protein Modification ◽  
Time Dependent ◽  
Dependent Manner ◽  
Intracellular Protein ◽  
Galactose Metabolism ◽  
Naturally Occurring ◽  
Leloir Pathway ◽  
Chemical Reporter ◽  
Complex Glycans

Galactose is a naturally occurring monosaccharide used to build complex glycans that has not been targeted for labeling as a metabolic reporter. Here, we characterize the cellular modification of proteins by using Ac46AzGal in a dose- and time-dependent manner. It is noted that a vast majority of this labeling of Ac46AzGal occurs intracellularly in a range of mammalian cells. We also provided evidence that this labeling is dependent on not only the enzymes of OGT responsible for O-GlcNAcylation but also the enzymes of GALT and GALE in the Leloir pathway. Notably, we discover that Ac46AzGal is not the direct substrate of OGT, and the labeling results may attribute to UDP-6AzGlc after epimerization of UDP-6AzGal via GALE. Together, these discoveries support the conclusion that Ac46AzGal as an analogue of galactose could metabolically label intracellular O-glycosylation modification, raising the possibility of characterization with impaired functions of the galactose metabolism in the Leloir pathway under certain conditions, such as galactosemias.

A NOVEL APPROACH OF REQUIREMENT GATHERING AND ANALYSIS FOR AGENT ORIENTED SOFTWARE ENGINEERING (AOSE)

2009 ◽  
Vol 19 (01) ◽  
pp. 79-111
Author(s):  
PRABHAT RANJAN ◽  
A. K. MISRA
Keyword(s):  
System Development ◽  
Specific Model ◽  
Agent Based Modeling ◽  
Agent Based ◽  
Domain Specific ◽  
Analysis Methodology ◽  
Analysis Process ◽  
Agent Oriented Software Engineering ◽  
Novel Approach ◽  
Specific Analysis

In this paper, an agent-based open and adaptive system development process has been proposed which continuously change and evolve to meet new requirements. The proposed methodology is based on a model-based technique that provides a specific model for the type of information to be gathered and uses this model to drive the domain specific analysis process. The focus is on a clear separtion between the requirement gathering and analysis phases. The analysis methodology further splits the analysis phase into the user_centric analysis and the system_centric analysis phases. Optimization of the system performance has also been proposed by exploiting the relationships and dependencies among roles and mapping criteria between roles to agents. The Gaia and ROADMAP models have been used as a basis to the proposed agent-based modeling method.

scholarly journals The Nuclear Receptor NR4A1 Induces a Form of Cell Death Dependent on Autophagy in Mammalian Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46422 ◽  
Author(s):  
Jimena Bouzas-Rodríguez ◽  
Gabriela Zárraga-Granados ◽  
Maria del Rayo Sánchez-Carbente ◽  
Rocío Rodríguez-Valentín ◽  
Xicotencatl Gracida ◽  
...  
Keyword(s):  
Cell Death ◽  
Nuclear Receptor ◽  
Mammalian Cells

scholarly journals VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies toPlasmodium falciparumPlacental Malaria

2016 ◽  
Vol 214 (4) ◽  
pp. 577-586 ◽  
Author(s):  
Justin Yai Alamou Doritchamou ◽  
Raul Herrera ◽  
Joan A. Aebig ◽  
Robert Morrison ◽  
Vu Nguyen ◽  
...  
Keyword(s):  
Domain Specific ◽  
Specific Analysis ◽  
Functional Antibodies

scholarly journals Correction: The Nuclear Receptor NR4A1 Induces a Form of Cell Death Dependent on Autophagy in Mammalian Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0118718 ◽  
Author(s):  
Jimena Bouzas-Rodríguez ◽  
Gabriela Zárraga-Granados ◽  
María del Rayo Sánchez-Carbente ◽  
Rocío Rodríguez-Valentín ◽  
Xicotencatl Gracida ◽  
...  
Keyword(s):  
Cell Death ◽  
Nuclear Receptor ◽  
Mammalian Cells

Pollination of Orchid Flowers: Quantitative and Domain-Specific Analysis of Ethylene Biosynthetic and Hormone-Induced Gene Expression

2017 ◽  
Vol 178 (3) ◽  
pp. 188-210 ◽  
Author(s):  
Sharman D. O’Neill ◽  
Anhthu Q. Bui ◽  
Daniel Potter ◽  
Xian Sheng Zhang
Keyword(s):  
Gene Expression ◽  
Domain Specific ◽  
Specific Analysis
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