scholarly journals Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme

ACS Catalysis ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 10612-10617 ◽  
Author(s):  
Abir Ganguly ◽  
Benjamin P. Weissman ◽  
Joseph A. Piccirilli ◽  
Darrin M. York
Keyword(s):  
Nucleophile Activation

Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation

2007 ◽  
pp. 2264 ◽  
Author(s):  
Masahiro Ueno ◽  
Misato Yonemoto ◽  
Masahiro Hashimoto ◽  
Andrew E. H. Wheatley ◽  
Hiroshi Naka ◽  
...  
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Nucleophile Activation

Metal- and Serine-Dependent Meta-Cleavage Product Hydrolases Utilize Similar Nucleophile-Activation Strategies

ACS Catalysis ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 11622-11632 ◽  
Author(s):  
Eugene Kuatsjah ◽  
Anson C. K. Chan ◽  
Timothy E. Hurst ◽  
Victor Snieckus ◽  
Michael E. P. Murphy ◽  
...  
Keyword(s):  
Cleavage Product ◽  
Nucleophile Activation

scholarly journals Magnesium-Induced Nucleophile Activation in the Guanylyltransferase mRNA Capping Enzyme

Biochemistry ◽  
2012 ◽  
Vol 51 (51) ◽  
pp. 10236-10243 ◽  
Author(s):  
Robert V. Swift ◽  
Chau D. Ong ◽  
Rommie E. Amaro
Keyword(s):  
Mrna Capping ◽  
Capping Enzyme ◽  
Nucleophile Activation

scholarly journals A Substrate-Assisted Mechanism of Nucleophile Activation in a Ser–His–Asp Containing C–C Bond Hydrolase

Biochemistry ◽  
2013 ◽  
Vol 52 (42) ◽  
pp. 7428-7438 ◽  
Author(s):  
Antonio C. Ruzzini ◽  
Shiva Bhowmik ◽  
Subhangi Ghosh ◽  
Katherine C. Yam ◽  
Jeffrey T. Bolin ◽  
...  
Keyword(s):  
Nucleophile Activation

scholarly journals A Nucleophile Activation Dyad in Ribonucleases

2002 ◽  
Vol 277 (39) ◽  
pp. 36770-36774 ◽  
Author(s):  
Pierre Mignon ◽  
Jan Steyaert ◽  
Remy Loris ◽  
Paul Geerlings ◽  
Stefan Loverix
Keyword(s):  
Nucleophile Activation

scholarly journals Insights into Alkene Activation by Gold: Nucleophile Activation with Base as a Trigger for Generation of Lewis Acidic Gold

ACS Catalysis ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 7357-7362 ◽  
Author(s):  
Yuyang Zhu ◽  
Wentong Zhou ◽  
Ellen M. Petryna ◽  
Brock R. Rogers ◽  
Cynthia S. Day ◽  
...  
Keyword(s):  
Nucleophile Activation

scholarly journals QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation

2005 ◽  
pp. 4399 ◽  
Author(s):  
Alessio Lodola ◽  
Marco Mor ◽  
Johannes C. Hermann ◽  
Giorgio Tarzia ◽  
Daniele Piomelli ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Hydrolase ◽  
Fatty Acid Amide ◽  
Nucleophile Activation

scholarly journals Asymmetric Lewis acid catalysis directed by octahedral rhodium centrochirality

2015 ◽  
Vol 6 (2) ◽  
pp. 1094-1100 ◽  
Author(s):  
Chuanyong Wang ◽  
Liang-An Chen ◽  
Haohua Huo ◽  
Xiaodong Shen ◽  
Klaus Harms ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Acid Catalysis ◽  
Lewis Acid Catalysis ◽  
Michael Additions ◽  
Asymmetric Catalyst ◽  
Nucleophile Activation

A chiral-at-metal octahedral rhodium(iii) complex serves as an effective asymmetric catalyst for Michael additions (electrophile activation) and α-aminations (nucleophile activation).

scholarly journals Nucleophile activation in PD…(D/E)xK metallonucleases: An experimental and computational pKa study

2010 ◽  
Vol 104 (6) ◽  
pp. 665-672 ◽  
Author(s):  
Fuqian Xie ◽  
James M. Briggs ◽  
Cynthia M. Dupureur
Keyword(s):  
Nucleophile Activation

Cu(I)-catalyzed asymmetric allylation of ketones and ketimines

2008 ◽  
Vol 80 (5) ◽  
pp. 1055-1062 ◽  
Author(s):  
Motomu Kanai ◽  
Reiko Wada ◽  
Tomoyuki Shibuguchi ◽  
Masakatsu Shibasaki
Keyword(s):  
Asymmetric Allylation ◽  
Effective Catalyst ◽  
Chiral Phosphines ◽  
Nucleophile Activation

Chiral CuF-catalyzed asymmetric allylation of ketones and ketimines is described. Nucleophile activation via transmetallation (allylboronate to allylcopper), which is facilitated by a cocatalyst [La(OiPr)3 or LiOiPr], is key for these reactions. A CuOTf-3KOtBu-DUPHOS complex is a comparably effective catalyst that reduces the required amount of chiral phosphines.

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