Merging Catalysis in Single Electron Steps with Photoredox Catalysis—Efficient and Sustainable Radical Chemistry

ACS Catalysis ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 3208-3212 ◽  
Author(s):  
Zhenhua Zhang ◽  
Ruben B. Richrath ◽  
Andreas Gansäuer
Keyword(s):  
Single Electron ◽  
Photoredox Catalysis ◽  
Radical Chemistry

scholarly journals Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

2020 ◽  
Author(s):  
Anna Davies ◽  
keegan fitzpatrick ◽  
Rick Betori ◽  
Karl Scheidt
Keyword(s):  
Carboxylic Acids ◽  
Late Stage ◽  
Pharmaceutical Compounds ◽  
Single Electron ◽  
Photoredox Catalysis ◽  
Radical Coupling ◽  
Electron Reduction

Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium <i>in situ</i> followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.

Visible light mediated synthesis of 4-aryl-1,2-dihydronaphthalene derivatives via single-electron oxidation or MHAT from methylenecyclopropanes

2021 ◽  
Vol 8 (1) ◽  
pp. 94-100
Author(s):  
Jiaxin Liu ◽  
Yin Wei ◽  
Min Shi
Keyword(s):  
Visible Light ◽  
Single Electron ◽  
Photoredox Catalysis ◽  
Synthetic Strategy ◽  
Rapid Construction

A new synthetic strategy of a single-electron oxidation and MHAT of methylenecyclopropanes (MCPs) for the rapid construction of 4-aryl-1,2-dihydronaphthalene derivatives by merging photoredox catalysis and cobalt catalysis has been developed.

Water: The Ideal Hydrogen-Atom Source in Free-Radical Chemistry Mediated by TiIII and Other Single-Electron-Transfer Metals?

2007 ◽  
Vol 46 (12) ◽  
pp. 1941-1941 ◽  
Author(s):  
Juan M. Cuerva ◽  
Araceli G. Campaña ◽  
José Justicia ◽  
Antonio Rosales ◽  
Juan L. Oller-López ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Free Radical ◽  
Hydrogen Atom ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Radical Chemistry ◽  
Atom Source ◽  
Free Radical Chemistry ◽  
The Ideal

scholarly journals Water: The Ideal Hydrogen-Atom Source in Free-Radical Chemistry Mediated by TiIII and Other Single-Electron-Transfer Metals?

2007 ◽  
Vol 119 (12) ◽  
pp. 1985-1985
Author(s):  
Juan M. Cuerva ◽  
Araceli G. Campaña ◽  
José Justicia ◽  
Antonio Rosales ◽  
Juan L. Oller-López ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Free Radical ◽  
Hydrogen Atom ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Radical Chemistry ◽  
Atom Source ◽  
Free Radical Chemistry ◽  
The Ideal

scholarly journals Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

2020 ◽  
Author(s):  
Anna Davies ◽  
keegan fitzpatrick ◽  
Rick Betori ◽  
Karl Scheidt
Keyword(s):  
Carboxylic Acids ◽  
Late Stage ◽  
Pharmaceutical Compounds ◽  
Single Electron ◽  
Photoredox Catalysis ◽  
Radical Coupling ◽  
Electron Reduction

Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium <i>in situ</i> followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.

scholarly journals α-Functionalization of Imines via Visible Light Photoredox Catalysis

Catalysts ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 562 ◽  
Author(s):  
Alberto F. Garrido-Castro ◽  
M. Carmen Maestro ◽  
José Alemán
Keyword(s):  
Visible Light ◽  
Building Blocks ◽  
Single Electron ◽  
Synthetic Chemistry ◽  
Photoredox Catalysis ◽  
Reaction Conditions ◽  
Radical Intermediates ◽  
Research Programs ◽  
Electron Reduction

The innate electrophilicity of imine building blocks has been exploited in organic synthetic chemistry for decades. Inspired by the resurgence in photocatalysis, imine reactivity has now been redesigned through the generation of unconventional and versatile radical intermediates under mild reaction conditions. While novel photocatalytic approaches have broadened the range and applicability of conventional radical additions to imine acceptors, the possibility to use these imines as latent nucleophiles via single-electron reduction has also been uncovered. Thus, multiple research programs have converged on this issue, delivering creative and practical strategies to achieve racemic and asymmetric α-functionalizations of imines under visible light photoredox catalysis.

Water: The Ideal Hydrogen-Atom Source in Free-Radical Chemistry Mediated by TiIII and Other Single-Electron-Transfer Metals?

2006 ◽  
Vol 118 (33) ◽  
pp. 5648-5652 ◽  
Author(s):  
Juan M. Cuerva ◽  
Araceli G. Campaña ◽  
José Justicia ◽  
Antonio Rosales ◽  
Juan L. Oller-López ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Free Radical ◽  
Hydrogen Atom ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Radical Chemistry ◽  
Atom Source ◽  
Free Radical Chemistry ◽  
The Ideal

A Single Electron Transfer (SET) Approach to C–H Amidation of Hydrazones via Visible-Light Photoredox Catalysis

2016 ◽  
Vol 18 (20) ◽  
pp. 5356-5359 ◽  
Author(s):  
Muliang Zhang ◽  
Yingqian Duan ◽  
Weipeng Li ◽  
Pan Xu ◽  
Jian Cheng ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Visible Light ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Photoredox Catalysis
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