Hydrogen Bond-Accelerated meta-Selective C–H Borylation of Aromatic Compounds and Expression of Functional Group and Substrate Specificities

ACS Catalysis ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 1705-1709 ◽  
Author(s):  
Xu Lu ◽  
Yusuke Yoshigoe ◽  
Haruka Ida ◽  
Mitsumi Nishi ◽  
Motomu Kanai ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Aromatic Compounds ◽  
Functional Group ◽  
Substrate Specificities

Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl) methane

Synthesis ◽  
2018 ◽  
Vol 50 (10) ◽  
pp. 2033-2040 ◽  
Author(s):  
Nolan Betterley ◽  
Sopanat Kongsriprapan ◽  
Suppisak Chaturonrutsamee ◽  
Pramchai Deelertpaiboon ◽  
Panida Surawatanawong ◽  
...  
Keyword(s):  
Aromatic Aldehyde ◽  
Aromatic Compounds ◽  
Functional Group ◽  
Salient Feature ◽  
Td Dft

Difluoro(phenylsulfanyl)methane (PhSCF2H) was found to undergo a reaction with aromatic compounds mediated by SnCl4, through a thionium intermediate characterized by NMR and TD-DFT analyses, leading to the formation of a mixture of S,S′-diphenyl dithioacetal and aromatic aldehyde which, after oxidative hydrolysis, provides the aromatic aldehyde in good to excellent yields. The salient feature of the present work is the reaction of activated aromatic compounds containing a deactivating ester functional group, leading to the formylated products in good yields.

Visible-Light-Induced Radical Polynitration of Arylboronic Acids: Synthesis of Polynitrophenols

Synthesis ◽  
2018 ◽  
Vol 50 (15) ◽  
pp. 2891-2896 ◽  
Author(s):  
Jinna Song ◽  
Xihe Bi ◽  
Qi Zhang ◽  
Kaki Raveendra Babu ◽  
Zhouliang Huang
Keyword(s):  
Visible Light ◽  
Aromatic Compounds ◽  
Functional Group ◽  
Simple Procedure ◽  
One Pot ◽  
Arylboronic Acids ◽  
Mild Conditions ◽  
Conventional Methods ◽  
Straightforward Approach

We report a visible light-assisted one-pot method for the synthesis of polynitrophenols through radical tandem hydroxylation and nitration of arylboronic acids by utilizing copper(II) nitrate tri­hydrate as the nitro source. This method features mild conditions, a simple procedure, and good functional group tolerance. Compared to conventional methods, this work provides a straightforward approach for the polynitration of aromatic compounds.

Hydrogen-Bond-Regulated Distinct Functional-Group Display at the Inner and Outer Wall of Vesicles

2015 ◽  
Vol 54 (23) ◽  
pp. 6755-6760 ◽  
Author(s):  
Amrita Sikder ◽  
Anindita Das ◽  
Suhrit Ghosh
Keyword(s):  
Hydrogen Bond ◽  
Functional Group ◽  
Outer Wall

scholarly journals Functional-Group-Directed Diastereoselective Hydrogenation of Aromatic Compounds. 1

1999 ◽  
Vol 64 (24) ◽  
pp. 8862-8867 ◽  
Author(s):  
Vidyadhar S. Ranade ◽  
Giambattista Consiglio ◽  
Roel Prins
Keyword(s):  
Aromatic Compounds ◽  
Functional Group ◽  
Diastereoselective Hydrogenation

scholarly journals Endogenous Binding of Steroid Molecules to DNA Nucleotides by a Ca2+/PO4- Process to Enable Gene Transcription

2020 ◽  
Author(s):  
Charles Schaper
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Ligand Binding ◽  
Gene Transcription ◽  
Functional Group ◽  
Ring Structure ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Steroid Molecule ◽  
First Time

Steroid hormones, such as cortisol, testosterone and estrogen, have powerful control over human physiology, growth, and reproduction, but efforts to deploy its potential, such as with glucocorticoids, a first-line defense of inflammation, are often met with severe side effects. Unfortunately, much is unknown about the basic interaction of steroid molecules with DNA, including its receptors, activators, factors, and the gene transcription procedure. In this research article, a remarkable finding is shown for the first time, in which it is illustrated through structural analysis that the base pairings of the four DNA nucleotides, adenine with thymine (A-T) and cytosine with guanine (C-G), form perfectly the classic four ring structure of the steroid molecule, which indicates the profound result put forth in this article that steroid molecules bind directly to DNA for the purpose of gene transcription. Further, critical to a basic understanding of DNA, it is resolved here of the location of the unusual ``missing" hydrogen bond of the A-T pairing, which has only two internal hydrogen bonds whereas C-G has three hydrogen bonds. It is shown that the third hydrogen bond for A-T is formed when the A-T nucleotide is coupled with corticosteroids, such as cortisol, which has an oxygen functional group that is perfectly positioned to form a hydrogen bond with the accessible oxygen-based functional group of thymine. In addition, to facilitate the binding process, it is shown that Ca2+ ions, which are associated with the ligand binding domain of the steroid receptor prior to its association with DNA, couple the oxygen-based functional groups at each end of the steroid molecule with the PO4- ions of adjacent nucleotides and thus bind the steroid molecule directly to the nucleic acid. The results are further amplified by analysis of the cortisol hormone and the ligand binding domain of the glucocorticoid receptor in its interaction with the A-T nucleotide pairing.

ChemInform Abstract: Functional-Group-Directed Diastereoselective Hydrogenation of Aromatic Compounds. Part 2.

ChemInform ◽  
2010 ◽  
Vol 31 (21) ◽  
pp. no-no
Author(s):  
Vidyadhar S. Ranade ◽  
Giambattista Consiglio ◽  
Roel Prins
Keyword(s):  
Aromatic Compounds ◽  
Functional Group ◽  
Diastereoselective Hydrogenation

Dimerization of Aromatic Compounds Using Palladium-Carbon-Catalyzed Suzuki–Miyaura Cross-Coupling by One-Pot Synthesis

Synlett ◽  
2018 ◽  
Vol 29 (06) ◽  
pp. 779-784 ◽  
Author(s):  
Guoliang Chen ◽  
Fangyu Du ◽  
Qifan Zhou ◽  
Dongdong Liu ◽  
Ting Fang ◽  
...  
Keyword(s):  
Aromatic Compounds ◽  
Functional Group ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Potassium Acetate ◽  
Carbon Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
Cross Coupling Reaction ◽  
High Yields

The aromatic dimers play a significant role in many aspects. Herein, we report a simple palladium-carbon catalyst that is highly effective for the dimerization of brominated aromatic compounds under mild conditions using abundant brominated aromatic compounds, bis(pinacolate)diboron and potassium acetate by a ‘one-pot’ method. This process, which we believe proceeds via a Suzuki–Miyaura cross-coupling reaction mechanism, allows access to a variety of aromatic compounds under mild reaction conditions and has a good functional group tolerance with moderate to high yields.

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