Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models

Shenshen Hu; Alexander V. Soudackov; Sharon Hammes-Schiffer; Judith P. Klinman

doi:10.1021/acscatal.7b00688

Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models

ACS Catalysis ◽

10.1021/acscatal.7b00688 ◽

2017 ◽

Vol 7 (5) ◽

pp. 3569-3574 ◽

Cited By ~ 26

Author(s):

Shenshen Hu ◽

Alexander V. Soudackov ◽

Sharon Hammes-Schiffer ◽

Judith P. Klinman

Keyword(s):

Electron Transfer ◽

Double Mutant ◽

Soybean Lipoxygenase ◽

Experimental Support ◽

Proton Coupled Electron Transfer ◽

Transfer Models

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Faculty Opinions recommendation of Fundamental Insights into Proton-Coupled Electron Transfer in Soybean Lipoxygenase from Quantum Mechanical/Molecular Mechanical Free Energy Simulations.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732596017.793543208 ◽

2018 ◽

Author(s):

Lynn Kamerlin ◽

Kshatresh Dubey

Keyword(s):

Electron Transfer ◽

Free Energy ◽

Quantum Mechanical ◽

Soybean Lipoxygenase ◽

Proton Coupled Electron Transfer ◽

Energy Simulations

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Theoretical studies of proton-coupled electron transfer: Models and concepts relevant to bioenergetics

Coordination Chemistry Reviews ◽

10.1016/j.ccr.2007.07.019 ◽

2008 ◽

Vol 252 (3-4) ◽

pp. 384-394 ◽

Cited By ~ 58

Author(s):

S HAMMESSCHIFFER ◽

E HATCHER ◽

H ISHIKITA ◽

J SKONE ◽

A SOUDACKOV

Keyword(s):

Electron Transfer ◽

Theoretical Studies ◽

Proton Coupled Electron Transfer ◽

Transfer Models

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Impact of Mutations on the Binding Pocket of Soybean Lipoxygenase: Implications for Proton-Coupled Electron Transfer

The Journal of Physical Chemistry Letters ◽

10.1021/acs.jpclett.8b02945 ◽

2018 ◽

Vol 9 (22) ◽

pp. 6444-6449 ◽

Cited By ~ 5

Author(s):

Pengfei Li ◽

Alexander V. Soudackov ◽

Sharon Hammes-Schiffer

Keyword(s):

Electron Transfer ◽

Binding Pocket ◽

Soybean Lipoxygenase ◽

Proton Coupled Electron Transfer

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Probing Nonadiabaticity in the Proton-Coupled Electron Transfer Reaction Catalyzed by Soybean Lipoxygenase

The Journal of Physical Chemistry Letters ◽

10.1021/jz501655v ◽

2014 ◽

Vol 5 (18) ◽

pp. 3274-3278 ◽

Cited By ~ 30

Author(s):

Alexander V. Soudackov ◽

Sharon Hammes-Schiffer

Keyword(s):

Electron Transfer ◽

Transfer Reaction ◽

Electron Transfer Reaction ◽

Soybean Lipoxygenase ◽

Proton Coupled Electron Transfer

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Fundamental Insights into Proton-Coupled Electron Transfer in Soybean Lipoxygenase from Quantum Mechanical/Molecular Mechanical Free Energy Simulations

Journal of the American Chemical Society ◽

10.1021/jacs.7b13642 ◽

2018 ◽

Vol 140 (8) ◽

pp. 3068-3076 ◽

Cited By ~ 22

Author(s):

Pengfei Li ◽

Alexander V. Soudackov ◽

Sharon Hammes-Schiffer

Keyword(s):

Electron Transfer ◽

Free Energy ◽

Quantum Mechanical ◽

Soybean Lipoxygenase ◽

Proton Coupled Electron Transfer ◽

Energy Simulations

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Proton-Coupled Electron Transfer in Soybean Lipoxygenase: Dynamical Behavior and Temperature Dependence of Kinetic Isotope Effects

Journal of the American Chemical Society ◽

10.1021/ja0667211 ◽

2007 ◽

Vol 129 (1) ◽

pp. 187-196 ◽

Cited By ~ 112

Author(s):

Elizabeth Hatcher ◽

Alexander V. Soudackov ◽

Sharon Hammes-Schiffer

Keyword(s):

Electron Transfer ◽

Temperature Dependence ◽

Isotope Effects ◽

Dynamical Behavior ◽

Kinetic Isotope Effects ◽

Soybean Lipoxygenase ◽

Proton Coupled Electron Transfer ◽

Kinetic Isotope

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Proton‐Coupled Electron Transfer in Soybean Lipoxygenase: Hydrogen Tunneling, Electrostatics, and Conformational Motions

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.475.1 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Sharon Hammes‐Schiffer

Keyword(s):

Electron Transfer ◽

Soybean Lipoxygenase ◽

Hydrogen Tunneling ◽

Proton Coupled Electron Transfer

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Proton-Coupled Electron Transfer in Soybean Lipoxygenase

Journal of the American Chemical Society ◽

10.1021/ja039606o ◽

2004 ◽

Vol 126 (18) ◽

pp. 5763-5775 ◽

Cited By ~ 135

Author(s):

Elizabeth Hatcher ◽

Alexander V. Soudackov ◽

Sharon Hammes-Schiffer

Keyword(s):

Electron Transfer ◽

Soybean Lipoxygenase ◽

Proton Coupled Electron Transfer

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Proton-Coupled Electron Transfer

10.1039/9781849733168 ◽

2011 ◽

Cited By ~ 2

Keyword(s):

Electron Transfer ◽

Proton Coupled Electron Transfer

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Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

ACS Omega ◽

10.1021/acsomega.1c03230 ◽

2021 ◽

Author(s):

Tatsushi Nakayama ◽

Ryo Honda

Keyword(s):

Electron Transfer ◽

Oxidative Degradation ◽

Mechanistic Study ◽

Proton Coupled Electron Transfer

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