scholarly journals Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

ACS Catalysis ◽  
2016 ◽  
Vol 6 (3) ◽  
pp. 1952-1970 ◽  
Author(s):  
Juan F. Collados ◽  
Ricard Solà ◽  
Syuzanna R. Harutyunyan ◽  
Beatriz Maciá
Keyword(s):  
Carbonyl Compounds ◽  
Catalytic Synthesis ◽  
Grignard Reagents ◽  
Chiral Alcohols

ChemInform Abstract: Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

ChemInform ◽  
2016 ◽  
Vol 47 (18) ◽  
Author(s):  
Juan F. Collados ◽  
Ricard Sola ◽  
Syuzanna R. Harutyunyan ◽  
Beatriz Macia
Keyword(s):  
Carbonyl Compounds ◽  
Catalytic Synthesis ◽  
Grignard Reagents ◽  
Chiral Alcohols

scholarly journals Transfer Hydrogenation from 2-propanol to Acetophenone Catalyzed by [RuCl2(η6-arene)P] (P = monophosphine) and [Rh(PP)2]X (PP = diphosphine, X = Cl−, BF4−) Complexes

Catalysts ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 162 ◽  
Author(s):  
Alberto Mannu ◽  
Arnald Grabulosa ◽  
Salvatore Baldino
Keyword(s):  
Transition Metals ◽  
Carbonyl Compounds ◽  
The Other ◽  
Transfer Hydrogenation ◽  
Chiral Alcohols ◽  
High Importance ◽  
Bidentate Phosphine ◽  
Turn Over Frequency ◽  
Turn Over ◽  
Reduction Of Ketones

The reduction of ketones through homogeneous transfer hydrogenation catalyzed by transition metals is one of the most important routes for obtaining alcohols from carbonyl compounds. The interest of this method increases when opportune catalytic precursors are able to perform the transformation in an asymmetric fashion, generating enantiomerically enriched chiral alcohols. This reaction has been extensively studied in terms of catalysts and variety of substrates. A large amount of information about the possible mechanisms is available nowadays, which has been of high importance for the development of systems with excellent outcomes in terms of conversion, enantioselectivity and Turn Over Frequency. On the other side, many mechanistic aspects are still unclear, especially for those catalytic precursors which have shown only moderate performances in transfer hydeogenation. This is the case of neutral [RuCl2(η6-arene)(P)] and cationic [Rh(PP)2]X (X = anion; P and PP = mono- and bidentate phosphine, respectively) complexes. Herein, a summary of the known information about the Transfer Hydrogenation catalyzed by these complexes is provided with a continuous focus on the more relevant mechanistic features.

Recent Advances in the Synthesis of Enantiomerically Enriched Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols through Addition of Organometallic Reagents to Carbonyl Compounds

Synthesis ◽  
2020 ◽  
Vol 52 (13) ◽  
pp. 1855-1873
Author(s):  
Senthil Narayanaperumal ◽  
Ricardo S. Schwab ◽  
Wystan K. O. Teixeira ◽  
Danilo Yano de Albuquerque
Keyword(s):  
Carbonyl Compounds ◽  
Building Blocks ◽  
Short Review ◽  
Biological Properties ◽  
Enantioselective Synthesis ◽  
Grignard Reagents ◽  
Organometallic Reagents ◽  
Important Family ◽  
Organolithium Reagents ◽  
Organozinc Reagents

Enantiomerically enriched diaryl, aryl heteroaryl, and dihetero­aryl alcohols are an important family of compounds known for their biological properties. Moreover, these molecules are highly privileged scaffolds used as building blocks for the synthesis of pharmaceutically relevant products. This short review provides background on the enantioselective arylation and heteroarylation of carbonyl compounds, as well as, the most significant improvements in this field with special emphasis on the application of organometallic reagents.1 Introduction2 Background on the Enantioselective Synthesis of Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols3 Organozinc Reagents4 Organolithium Reagents5 Grignard Reagents6 Organoaluminum Reagents7 Organotitanium Reagents8 Organobismuth Reagents9 Miscellaneous10 Conclusion

ChemInform Abstract: Reaction of Grignard Reagents with Carbonyl Compounds under Continuous Flow Conditions.

ChemInform ◽  
2010 ◽  
Vol 41 (36) ◽  
pp. no-no
Author(s):  
E. Riva ◽  
S. Gagliardi ◽  
M. Martinelli ◽  
D. Passarella ◽  
D. Vigo ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Continuous Flow ◽  
Grignard Reagents ◽  
Flow Conditions

ChemInform Abstract: Chiral Phosphine-Phosphite Ligands in the Enantioselective 1,4-Addition of Grignard Reagents to α,β-Unsaturated Carbonyl Compounds.

ChemInform ◽  
2011 ◽  
Vol 42 (49) ◽  
pp. no-no
Author(s):  
Qaseem Naeemi ◽  
Tobias Robert ◽  
Darius P. Kranz ◽  
Janna Velder ◽  
Hans-Guenther Schmalz
Keyword(s):  
Carbonyl Compounds ◽  
Grignard Reagents ◽  
Phosphite Ligands
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