scholarly journals Synergistic Interaction between Oxides of Copper and Iron for Production of Fatty Alcohols from Fatty Acids

ACS Catalysis ◽  
2015 ◽  
Vol 5 (11) ◽  
pp. 6719-6723 ◽  
Author(s):  
Kapil Kandel ◽  
Umesh Chaudhary ◽  
Nicholas C. Nelson ◽  
Igor I. Slowing
Keyword(s):  
Fatty Acids ◽  
Synergistic Interaction ◽  
Fatty Alcohols

scholarly journals Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

Redox Biology ◽  
2018 ◽  
Vol 15 ◽  
pp. 86-96 ◽  
Author(s):  
Francesco Bellanti ◽  
Rosanna Villani ◽  
Rosanna Tamborra ◽  
Maria Blonda ◽  
Giuseppina Iannelli ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Mitochondrial Function ◽  
Synergistic Interaction

scholarly journals Photoassimilation of Fatty Acids, Fatty Alcohols and Sugars by Euglena gracilis Z

Microbiology ◽  
1988 ◽  
Vol 134 (1) ◽  
pp. 61-66
Author(s):  
K. HOSOTANI ◽  
T. OHKOCHI ◽  
H. INUI ◽  
A. YOKOTA ◽  
Y. NAKANO ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Euglena Gracilis ◽  
Fatty Alcohols ◽  
Euglena Gracilis Z

scholarly journals Biochemical Characterization of CYP505D6, a Self-Sufficient Cytochrome P450 from the White-Rot FungusPhanerochaete chrysosporium

2018 ◽  
Vol 84 (22) ◽  
Author(s):  
Kiyota Sakai ◽  
Fumiko Matsuzaki ◽  
Lisa Wise ◽  
Yu Sakai ◽  
Sadanari Jindou ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cytochrome P450 ◽  
Phanerochaete Chrysosporium ◽  
Carbon Chain ◽  
Fatty Alcohols ◽  
White Rot ◽  
Wild Type ◽  
Content Type ◽  
Attractive Candidate ◽  
Chain Lengths

ABSTRACTThe activity of a self-sufficient cytochrome P450 enzyme, CYP505D6, from the lignin-degrading basidiomycetePhanerochaete chrysosporiumwas characterized. Recombinant CYP505D6 was produced inEscherichia coliand purified. In the presence of NADPH, CYP505D6 used a series of saturated fatty alcohols with C9–18carbon chain lengths as the substrates. Hydroxylation occurred at the ω-1 to ω-6 positions of such substrates with C9–15carbon chain lengths, except for 1-dodecanol, which was hydroxylated at the ω-1 to ω-7 positions. Fatty acids were also substrates of CYP505D6. Based on the sequence alignment, the corresponding amino acid of Tyr51, which is located at the entrance to the active-site pocket in CYP102A1, was Val51 in CYP505D6. To understand the diverse hydroxylation mechanism, wild-type CYP505D6 and its V51Y variant and wild-type CYP102A1 and its Y51V variant were generated, and the products of their reaction with dodecanoic acid were analyzed. Compared with wild-type CYP505D6, its V51Y variant generated few products hydroxylated at the ω-4 to ω-6 positions. The products generated by wild-type CYP102A1 were hydroxylated at the ω-1 to ω-4 positions, whereas its Y51V variant generated ω-1 to ω-7 hydroxydodecanoic acids. These observations indicated that Val51 plays an important role in determining the regiospecificity of fatty acid hydroxylation, at least that at the ω-4 to ω-6 positions. Aromatic compounds, such as naphthalene and 1-naphthol, were also hydroxylated by CYP505D6. These findings highlight a unique broad substrate spectrum of CYP505D6, rendering it an attractive candidate enzyme for the biotechnological industry.IMPORTANCEPhanerochaete chrysosporiumis a white-rot fungus whose metabolism of lignin, aromatic pollutants, and lipids has been most extensively studied. This fungus harbors 154 cytochrome P450-encoding genes in the genome. As evidenced in this study,P. chrysosporiumCYP505D6, a fused protein of P450 and its reductase, hydroxylates fatty alcohols (C9–15) and fatty acids (C9–15) at the ω-1 to ω-7 or ω-1 to ω-6 positions, respectively. Naphthalene and 1-naphthol were also hydroxylated, indicating that the substrate specificity of CYP505D6 is broader than those of the known fused proteins CYP102A1 and CYP505A1. The substrate versatility of CYP505D6 makes this enzyme an attractive candidate for biotechnological applications.

Fatty alcohols: enzymatically from free fatty acids

2018 ◽  
Vol 44 ◽  
pp. S124
Author(s):  
M. Horvat ◽  
J. Zabielska ◽  
R. Kourist ◽  
M. Winkler
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Fatty Alcohols

scholarly journals Impact of Selected Cosmetic Ingredients on Common Microorganisms of Healthy Human Skin

Cosmetics ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 45 ◽  
Author(s):  
Dorota Dobler ◽  
Thomas Schmidts ◽  
Sören Wildenhain ◽  
Ilona Seewald ◽  
Michael Merzhäuser ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Human Skin ◽  
Chain Length ◽  
Skin Diseases ◽  
Free Acid ◽  
Fatty Alcohols ◽  
Fatty Acid Esters ◽  
Bacterial Strains ◽  
Acid Esters

Human skin is a complex ecosystem and is host to a large number of microorganisms. When the bacterial ecosystem is balanced and differentiated, skin remains healthy. However, the use of cosmetics can change this balance and promote the appearance of skin diseases. The skin’s microorganisms can utilize some cosmetic components, which either promote their growth, or produce metabolites that influence the skin environment. In this study, we tested the ability of the Malassezia species and some bacterial strains to assimilate substances frequently used in dermal formulations. The growth capability of microorganisms was determined and their lipase activity was analyzed. The growth of all Malassezia spp. in the presence of free acids, free acid esters, and fatty alcohols with a fatty chain length above 12 carbon atoms was observed. No growth was observed in the presence of fatty alcohol ethers, secondary fatty alcohols, paraffin- and silicon-based substances, polymers, polyethylene glycols, quaternary ammonium salts, hydroxy fatty acid esters, or fatty acids and fatty acid esters with a fatty chain length shorter than 12 carbon atoms. The hydrolysis of esters by Malassezia lipases was detected using High Performance Thin Layer Chromatography (HPTLC). The production of free fatty acids as well as fatty alcohols was observed. The growth promotion or inhibition of bacterial strains was only found in the presence of a few ingredients. Based on these results, formulations containing microbiome inert ingredients were developed.

Size distributions of n-alkanes, fatty acids and fatty alcohols in springtime aerosols from New Delhi, India

2016 ◽  
Vol 219 ◽  
pp. 957-966 ◽  
Author(s):  
Mingjie Kang ◽  
Pingqing Fu ◽  
Shankar G. Aggarwal ◽  
Sudhanshu Kumar ◽  
Ye Zhao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Alcohols ◽  
New Delhi ◽  
Size Distributions

Analysis of mixtures of fatty acids and fatty alcohols in fermentation broth

2014 ◽  
Vol 1323 ◽  
pp. 66-72 ◽  
Author(s):  
Yilan Liu ◽  
Ting Chen ◽  
Maohua Yang ◽  
Caixia Wang ◽  
Weiyan Huo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fermentation Broth ◽  
Fatty Alcohols
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