Highly Regioselective Difluoroalkylarylation of Butadiene through a Nickel-Catalyzed Tandem Radical Process

ACS Catalysis ◽  
2021 ◽  
pp. 14848-14853
Author(s):  
Shucheng Ma ◽  
Fangjie Li ◽  
Guisheng Zhang ◽  
Lei Shi ◽  
Xiaoming Wang
Keyword(s):  
Radical Process

A Short Synthesis of (+)-Brefeldin C via Enantioselective Radical Hydroalkynylation

2019 ◽  
Author(s):  
Lars Gnägi ◽  
Severin Vital Martz ◽  
Daniel Meyer ◽  
Robin Marc Schärer ◽  
Philippe Renaud
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Oxidation State ◽  
Single Step ◽  
Radical Process ◽  
Target Molecule ◽  
Short Synthesis ◽  
The One

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach is based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use of a furan substituent allows to achieve a high trans diastereoselectivity during the radical process and it contains the four carbon atoms C1–C4 of the natural product in an oxidation state closely related to the one of the target molecule. The eight-step synthesis require six product purifications and it provides (+)-brefeldin C in 18% overall yield.</p></div></div></div></div>

Generation of (E)-β-sulfonyl enamines from sulfur dioxide via a radical process

2021 ◽  
Vol 8 (8) ◽  
pp. 1789-1794
Author(s):  
Xiaodong Tu ◽  
Jiapian Huang ◽  
Wenlin Xie ◽  
Tonghao Zhu ◽  
Jie Wu
Keyword(s):  
Sulfur Dioxide ◽  
Radical Process ◽  
Three Component Reaction

An iron(ii)-catalyzed three-component reaction of O-acyl oximes, sulfur dioxide, and N-vinylacetamides is accomplished. Diverse (E)-β-sulfonyl enamines are obtained in moderate to good yields by using this protocol with excellent stereoselectivity and regioselectivity.

Desulfonylation via Radical Process: Recent Developments in Organic Synthesis

2021 ◽  
Author(s):  
Xue-Qiang Chu ◽  
Danhua Ge ◽  
Yan-Ying Cui ◽  
Zhi-Liang Shen ◽  
Chao-Jun Li
Keyword(s):  
Organic Synthesis ◽  
Radical Process ◽  
Recent Developments

ChemInform Abstract: A Tandem Carbonylation/Cyclization Radical Process of 1-(2-Iodoethyl)indoles and Pyrrole.

ChemInform ◽  
2010 ◽  
Vol 30 (52) ◽  
pp. no-no
Author(s):  
Luis D. Miranda ◽  
Raymundo Cruz-Almanza ◽  
Miriam Pavon ◽  
Edith Alva ◽  
Joseph M. Muchowski
Keyword(s):  
Radical Process

Visible-Light-Induced Nitrogen-Centered Radical Process for the Construction of 3-Acylcoumarins

2021 ◽  
Author(s):  
Quan Zhou ◽  
Fang-Ting Xiong ◽  
Pu Chen ◽  
Biquan Xiong ◽  
Kewen Tang ◽  
...  
Keyword(s):  
Visible Light ◽  
Cyclization Reactions ◽  
Radical Process

A nitrogen-centered radical-mediated strategy is described to synthesize functionalized 3-acylcoumarins. This process is enabled by visible-light-induced acylation/cyclization reactions of alkynoates with various acyl oxime compounds in acetonitrile. The difunctionalization of...

Base promoted direct difunctionalization/cascade cyclization of 1,6-enynes

2018 ◽  
Vol 54 (42) ◽  
pp. 5334-5337 ◽  
Author(s):  
Ming Li ◽  
Cui-Tian Wang ◽  
Yi-Feng Qiu ◽  
Xin-Yu Zhu ◽  
Ya-Ping Han ◽  
...  
Keyword(s):  
Radical Process ◽  
Cascade Cyclization

A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF2 radical process has been developed.

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