A Paradigm Shift in the Catalytic Cycle of P450: The Preparatory Choreography during O2 Binding and Origins of the Necessity for Two Protonation Pathways

ACS Catalysis ◽  
2020 ◽  
Vol 10 (19) ◽  
pp. 11481-11492
Author(s):  
Surajit Kalita ◽  
Sason Shaik ◽  
Hemanta K. Kisan ◽  
Kshatresh Dutta Dubey
Keyword(s):  
Paradigm Shift ◽  
Catalytic Cycle ◽  
O2 Binding

A Possible Paradigm Shift in Thinking About Thinking

1985 ◽  
Vol 30 (1) ◽  
pp. 17-17
Author(s):  
Marion Perlmutter
Keyword(s):  
Paradigm Shift

The Postindustrial Paradigm Shift: From Roles to Relationships

1994 ◽  
Vol 39 (2) ◽  
pp. 197-198
Author(s):  
Raymond T. Garza
Keyword(s):  
Paradigm Shift

Extreme Teams: Is a Paradigm Shift Required?

2011 ◽  
Author(s):  
Wendy L. Bedwell ◽  
Aaron S. Dietz ◽  
Kathryn E. Keeton ◽  
Daniel Tani ◽  
Gerald Goodwin ◽  
...  
Keyword(s):  
Paradigm Shift

Posttransplant CMV infection and the role of immunosuppression (Sponsor: Novartis Pharma GmbH, Nürnberg)

2016 ◽  
Vol 04 (01) ◽  
pp. 4-10
Keyword(s):  
Lower Incidence ◽  
Paradigm Shift ◽  
Mtor Inhibitor ◽  
De Novo ◽  
Expert Panel ◽  
Risk Of Infection ◽  
Cmv Infection ◽  
Expert Meeting ◽  
Selection Of

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.

The Structure and Rearrangements of a Complete Polyketide Synthase Module During its Catalytic Cycle

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
DH Sherman ◽  
G Skiniotis ◽  
JL Smith ◽  
K Håkansson ◽  
S Dutta ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Catalytic Cycle

Two Intellectual Landmarks in the Year 1749

2019 ◽  
Vol 17 (2) ◽  
pp. 101-123
Author(s):  
Farhad Rassekh
Keyword(s):  
Paradigm Shift ◽  
David Hume ◽  
Adam Smith ◽  
Considerable Extent ◽  
Monetary Theory ◽  
Economic Theories ◽  
Classical Economics ◽  
Wealth Of Nations ◽  
Economic Thinking

In the year 1749 Adam Smith conceived his theory of commercial liberty and David Hume laid the foundation of his monetary theory. These two intellectual developments, despite their brevity, heralded a paradigm shift in economic thinking. Smith expanded and promulgated his theory over the course of his scholarly career, culminating in the publication of The Wealth of Nations in 1776. Hume elaborated on the constituents of his monetary framework in several essays that were published in 1752. Although Smith and Hume devised their economic theories in 1749 independently, these theories complemented each other and to a considerable extent created the structure of classical economics.

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