Preparation of Reduction-Sensitive Branched Block–Statistical Copolymers for Controlled Drug Release via a Secondary in Situ Branching Reaction

2019 ◽  
Vol 2 (2) ◽  
pp. 263-272
Author(s):  
Yuping Liu ◽  
Guiying Kang ◽  
Lu Sun ◽  
Chao Meng ◽  
Jinlei Peng ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release

scholarly journals Chemiluminescence-initiated and in situ-enhanced photoisomerization for tissue-depth-independent photo-controlled drug release

2019 ◽  
Vol 10 (5) ◽  
pp. 1401-1409 ◽  
Author(s):  
Yufu Tang ◽  
Xiaomei Lu ◽  
Chao Yin ◽  
Hui Zhao ◽  
Wenbo Hu ◽  
...  
Keyword(s):  
Drug Release ◽  
Penetration Depth ◽  
Controlled Drug Release ◽  
Tissue Penetration

Tissue-penetration-depth-independent self-luminescence is highly expected to perform photoisomerization-related bioapplications in vivo to overcome the limitation of shallow tissue-penetration from external photoexcitation.

Vehicle-dependent in situ modification of membrane-controlled drug release

1998 ◽  
Vol 51 (1) ◽  
pp. 23-34 ◽  
Author(s):  
G. Imanidis ◽  
S. Helbing-Strausak ◽  
R. Imboden ◽  
H. Leuenberger
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
In Situ Modification

In Situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release

ACS Nano ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. 789-798 ◽  
Author(s):  
Penghui Zhang ◽  
Zhimei He ◽  
Chen Wang ◽  
Jiangning Chen ◽  
Jingjing Zhao ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Logic Operation ◽  
Multiplexed Imaging

scholarly journals Development of a Cyclodextrin-Based Mucoadhesive-Thermosensitive In Situ Gel for Clonazepam Intranasal Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 969
Author(s):  
Marzia Cirri ◽  
Francesca Maestrelli ◽  
Giulia Nerli ◽  
Natascia Mennini ◽  
Mario D’Ambrosio ◽  
...  
Keyword(s):  
Drug Release ◽  
Gelation Time ◽  
Sodium Hyaluronate ◽  
Controlled Drug Release ◽  
Intranasal Delivery ◽  
Gelation Temperature ◽  
In Situ Gel ◽  
Permeation Studies ◽  
The One

A thermosensitive, mucoadhesive in-situ gel for clonazepam (CLZ) intranasal delivery was developed, which aimed to achieve prolonged in-situ residence and controlled drug release, overcoming problems associated with its oral or parenteral administration. Poloxamer was selected as a thermosensitive polymer and chitosan glutamate and sodium hyaluronate as mucoadhesive and permeation enhancer. Moreover, randomly methylated β-Cyclodextrin (RAMEB) was used to improve the low drug solubility. A screening DoE was applied for a systematic examination of the effect of varying the formulation components proportions on gelation temperature, gelation time and pH. Drug-loaded gels at different clonazepam-RAMEB concentrations were then prepared and characterized for gelation temperature, gelation time, gel strength, mucoadhesive strength, mucoadhesion time, and drug release properties. All formulations showed suitable gelation temperature (29–30.5 °C) and time (50–65 s), but the one with the highest drug-RAMEB concentration showed the best mucoadhesive strength, longest mucoadhesion time (6 h), and greatest release rate. Therefore, it was selected for cytotoxicity and permeation studies through Caco-2 cells, compared with an analogous formulation without RAMEB and a drug solution. Both gels were significantly more effective than the solution. However, RAMEB was essential not only to promote drug release, but also to reduce drug cytotoxicity and further improve its permeability.

scholarly journals In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging

2016 ◽  
Vol 59 (11) ◽  
pp. 892-900 ◽  
Author(s):  
Malathi Mathiyazhakan ◽  
Paul Kumar Upputuri ◽  
Kathyayini Sivasubramanian ◽  
Ashish Dhayani ◽  
Praveen Kumar Vemula ◽  
...  
Keyword(s):  
Drug Release ◽  
Photoacoustic Imaging ◽  
Controlled Drug Release ◽  
In Situ Synthesis ◽  
Gold Nanostars
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