Polymer Composites with Cork Particles Functionalized by Surface Polymerization for Fused Deposition Modeling

In the present scenario, the industries are looking for creating the model quickly and making the prototype. Additive manufacturing (AM) is a rising technology for a hefty choice of applications. This route has plenty of advantages such as the availability of a wide range of materials, fabrication speed and resolution of the final components. The current paper deals with the review of the recent developments in additive manufacturing methods and their applications. Further, the discussion has been made about the various materials used for additive manufacturing such as ceramic, polymer, composites and biomaterials. The survey denotes that fused deposition modeling has received the widespread attention of the researchers. Finally, some of the gaps in the research are found and reported.

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Two-Compartment Capsular Devices for Oral Pulsatile Delivery 3D-Printed by Fused Deposition Modeling

10.26226/morressier.57d6b2b6d462b8028d88d9d6 ◽

2016 ◽

Author(s):

Federica Casati

Keyword(s):

Fused Deposition Modeling ◽

Fused Deposition ◽

Deposition Modeling ◽

3D Printed ◽

Pulsatile Delivery

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Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

10.26434/chemrxiv.5851950.v1 ◽

2018 ◽

Cited By ~ 1

Author(s):

Michael A. Luzuriaga ◽

Danielle R. Berry ◽

John C. Reagan ◽

Ronald A. Smaldone ◽

Jeremiah J. Gassensmith

Keyword(s):

Drug Delivery ◽

3D Printing ◽

Transdermal Drug Delivery ◽

Fused Deposition Modeling ◽

Fused Deposition ◽

Modeling Software ◽

Deposition Modeling ◽

3D Printed ◽

Microfabrication Technique ◽

Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

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