Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores

2022 ◽  
Author(s):  
Ivan S. Alferiev ◽  
Ilia Fishbein ◽  
Robert J. Levy ◽  
Michael Chorny
Keyword(s):  
Chemical Strategy

Synthesis of few-layer 1T′-MoTe2 ultrathin nanosheets for high-performance pseudocapacitors

2017 ◽  
Vol 5 (3) ◽  
pp. 1035-1042 ◽  
Author(s):  
Ming Liu ◽  
Zhaojie Wang ◽  
Junxue Liu ◽  
Guijuan Wei ◽  
Jiao Du ◽  
...  
Keyword(s):  
High Performance ◽  
Ultrathin Nanosheets ◽  
Supercapacitor Performance ◽  
Chemical Strategy

A colloidal chemical strategy has been developed for the synthesis of ultrathin 1T′-MoTe2 nanosheets, showing an enhanced supercapacitor performance.

Organic/Inorganic Hybrid Silicate Materials for Optical Applications; Highly Fluorinated Hybrid Glasses Doped with (Erbium-ions/CdSe nanoparticles) for Laser Amplifier Material

2004 ◽  
Vol 846 ◽  
Author(s):  
Kyung M. Choi ◽  
John A. Rogers
Keyword(s):  
Fluorescence Intensity ◽  
Nano Particles ◽  
Laser Amplifier ◽  
Inorganic Hybrid ◽  
New Family ◽  
Erbium Ions ◽  
Optical Applications ◽  
Hybrid Silicate ◽  
Chemical Strategy ◽  
Silicate Materials

A new family of organic/inorganic hybrid silicate materials, bridged polysilsesquioxanes, was designed and synthesized through a molecular-level mixing technique. Since hybrid materials in the molecular-composite level, whose domain sizes are in the nanometer-scale, and whose constituents often lose individual identities and thus create new properties, we obtained a set of improved properties from those organically modified glasses. By modifying the Si-O-Si polymeric network, in this study, we produced controllable, porous hybrid glasses for facile and uniform doping of various ions, metals or semiconductor particles. By taking advantage of void volume created in those molecularly modified silicate systems, novel optical materials with designed properties can thus be achieved. Via a chemical strategy, we designed hexylene- or fluoroalkylene-bridged hybrid glasses doped with both Er+3 ions and CdSe nano-particles for the development of new laser amplifier materials. In photoluminescence experiments, a significant enhancement in fluorescence intensity at 1540 nm has been obtained from the fluoroalkylene-bridged glass. The presence of CdSe nano-particles, by virtue of their low phonon energy, also appears to significantly influence the nature of the surrounding environment of Er+3 ions in those modified silicate systems, resulting in the increased fluorescence intensity.

scholarly journals A Study for the Access to a Semi-synthetic Regioisomer of Natural Fucosylated Chondroitin Sulfate with Fucosyl Branches on N-acetyl-Galactosamine Units

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 655 ◽  
Author(s):  
Giulia Vessella ◽  
Serena Traboni ◽  
Anna V. A. Pirozzi ◽  
Antonio Laezza ◽  
Alfonso Iadonisi ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Anticoagulant Activity ◽  
The Body ◽  
New Drugs ◽  
Coagulation Cascade ◽  
Drug Candidate ◽  
Heterogeneous Structure ◽  
Anticoagulant Drug ◽  
Chemical Strategy

Fucosylated chondroitin sulfate (fCS) is a glycosaminoglycan found up to now exclusively in the body wall of sea cucumbers. It shows several interesting activities, with the anticoagulant and antithrombotic as the most attractive ones. Its different mechanism of action on the blood coagulation cascade with respect to heparin and the retention of its activity by oral administration make fCS a very promising anticoagulant drug candidate for heparin replacement. Nonetheless, its typically heterogeneous structure, the detection of some adverse effects and the preference for new drugs not sourced from animal tissues, explain how mandatory is to open an access to safer and less heterogeneous non-natural fCS species. Here we contribute to this aim by investigating a suitable chemical strategy to obtain a regioisomer of the natural fCS polysaccharide, with sulfated l-fucosyl branches placed at position O-6 of N-acetyl-d-galactosamine (GalNAc) units instead of O-3 of d-glucuronic acid (GlcA) ones, as in natural fCSs. This strategy is based on the structural modification of a microbial sourced chondroitin polysaccharide by regioselective insertion of fucosyl branches and sulfate groups on its polymeric structure. A preliminary in vitro evaluation of the anticoagulant activity of three of such semi-synthetic fCS analogues is also reported.

scholarly journals A Chemical Strategy for Protease Substrate Profiling

2019 ◽  
Vol 26 (6) ◽  
pp. 901-907.e6 ◽  
Author(s):  
Andrew R. Griswold ◽  
Paolo Cifani ◽  
Sahana D. Rao ◽  
Abram J. Axelrod ◽  
Matthew M. Miele ◽  
...  
Keyword(s):  
Protease Substrate ◽  
Chemical Strategy
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