pH-Responsive PEG/PAA Multilayer Assemblies for Reversible Adhesion of Micro-Objects

2020 ◽  
Vol 2 (12) ◽  
pp. 5646-5653
Author(s):  
Cédric C. Buron ◽  
Tjasa Vrlinic ◽  
Tristan Le Gallou ◽  
Sophie Lakard ◽  
Aude Bolopion ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Reversible Adhesion ◽  
Multilayer Assemblies

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Skin and dry adhesion

2018 ◽  
Author(s):  
Changhyun Pang ◽  
Chanseok Lee ◽  
Hoon Eui Jeong ◽  
Kahp-Yang Suh
Keyword(s):  
Material Properties ◽  
Structural Features ◽  
Mechanical Interlocking ◽  
Multi Scale ◽  
Skin Patch ◽  
Reversible Adhesion ◽  
Dry Adhesion ◽  
Close Observation ◽  
Dry Adhesives ◽  
Shed Light

Close observation of various attachment systems in animal skins has revealed various exquisite multi-scale architectures for essential functions such as locomotion, crawling, mating, and protection from predators. Some of these adhesion systems of geckos and beetles have unique structural features (e.g. high-aspect ratio, tilted angle, and hierarchical nanostructure), resulting in mechanical interlocking mediated by van der Waals forces or liquid secretion (capillary force). In this chapter, we present an overview of recent advances in bio-inspired, artificial dry adhesives, and biomimetics in the context of nanofabrication and material properties. In addition, relevant bio-inspired structural materials, devices (clean transportation device, interlocker, biomedical skin patch, and flexible strain-gauge sensor) and microrobots are briefly introduced, which would shed light on future smart, directional, and reversible adhesion systems.

A fast response, large deformation, excellent mechanical pH-responsive polyacrylonitrile/polyimide bilayer film

Polymer ◽  
2020 ◽  
Vol 191 ◽  
pp. 122271
Author(s):  
Xu Wang ◽  
Chengyong He ◽  
Longbo Luo ◽  
Daiqiang Chen ◽  
Xiangyang Liu ◽  
...  
Keyword(s):  
Large Deformation ◽  
Fast Response ◽  
Bilayer Film ◽  
Ph Responsive

Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity

2019 ◽  
Vol 104 ◽  
pp. 109746 ◽  
Author(s):  
Cui Ning ◽  
Jing Jiajia ◽  
Li Meng ◽  
Qi Hongfei ◽  
Wu Xianglong ◽  
...  
Keyword(s):  
Electrophoretic Deposition ◽  
Ph Responsive
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