Near-Infrared- and Magnetic-Field-Responsive NaYF4:Er3+/Yb3+@SiO2@AuNP@Fe3O4 Nanocomposites for Hyperthermia Applications Induced by Fluorescence Resonance Energy Transfer and Surface Plasmon Absorption

2019 ◽  
Vol 2 (11) ◽  
pp. 7350-7361 ◽  
Author(s):  
Abhishek Kumar Soni ◽  
Rashmi Joshi ◽  
Bheeshma Pratap Singh ◽  
N. Naveen Kumar ◽  
Raghumani Singh Ningthoujam
Keyword(s):  
Magnetic Field ◽  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Surface Plasmon ◽  
Near Infrared ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Plasmon Absorption ◽  
Surface Plasmon Absorption ◽  
Fluorescence Resonance

scholarly journals Discovering Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors: Virtual Screening, Surface Plasmon Resonance, and Fluorescence Resonance Energy Transfer Assays

2006 ◽  
Vol 11 (8) ◽  
pp. 915-921 ◽  
Author(s):  
Lili Chen ◽  
Shuai Chen ◽  
Chunshan Gui ◽  
Jianhua Shen ◽  
Xu Shen ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Surface Plasmon Resonance ◽  
Virtual Screening ◽  
Severe Acute Respiratory Syndrome ◽  
Fluorescence Resonance Energy Transfer ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Fluorescence Resonance

An integrated system has been developed for discovering potent inhibitors of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) by virtual screening correlating with surface plasmon resonance (SPR) and fluorescence resonance energy transfer (FRET) technologies-based assays. The authors screened 81,287 small molecular compounds against SPECS database by virtual screening; 256 compounds were subsequently selected for biological evaluation. Through SPR technology-based assay, 52 from these 256 compounds were discovered to show binding to SARS-CoV 3CLpro. The enzymatic inhibition activities of these 52 SARS-CoV 3CLpro binders were further applied to FRET-based assay, and IC50 values were determined. Based on this integrated assay platform, 8 new SARS-CoV 3CLpro inhibitors were discovered. The fact that the obtained IC50 values for the inhibitors are in good accordance with the discovered dissociation equilibrium constants (KDs) assayed by SPR implied the reliability of this platform. Our current work is hoped to supply a powerful approach in the discovery of potent SARS-CoV 3CLpro inhibitors, and the determined inhibitors could be used as possible lead compounds for further research.

A diphenylacrylonitrile conjugated porphyrin with near-infrared emission by AIE–FRET

2019 ◽  
Vol 43 (8) ◽  
pp. 3317-3322 ◽  
Author(s):  
Chenyang Han ◽  
Shengjie Jiang ◽  
Jiabin Qiu ◽  
Hongyu Guo ◽  
Fafu Yang
Keyword(s):  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Near Infrared ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Infrared Emission ◽  
Aggregation Induced Emission ◽  
Fluorescence Resonance ◽  
Near Infrared Emission

The strong aggregation induced emission–fluorescence resonance energy transfer (AIE–FRET) effect was observed for diphenylacrylonitrile units and porphyrin units.

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