Bumpy Hollow Gold Nanospheres for Theranostic Applications: Effect of Surface Morphology on Photothermal Conversion Efficiency

2019 ◽  
Vol 2 (2) ◽  
pp. 1072-1081 ◽  
Author(s):  
Sarah A. Lindley ◽  
Jin Z. Zhang
2020 ◽  
Vol 127 (14) ◽  
pp. 145303 ◽  
Author(s):  
Anjana James ◽  
Prajisha Pradeep ◽  
Harish Barshilia ◽  
Vinayak B. Kamble

2017 ◽  
Vol 122 (25) ◽  
pp. 13304-13313 ◽  
Author(s):  
Evan T. Vickers ◽  
Monalisa Garai ◽  
Sara Bonabi Naghadeh ◽  
Sarah Lindley ◽  
Jessica Hibbs ◽  
...  

NANO ◽  
2021 ◽  
pp. 2150037
Author(s):  
Lijie Yang ◽  
Jinhua Wang ◽  
Liying Sun ◽  
Yisi Zhang ◽  
Peng Huang ◽  
...  

Gold nanoparticles are promising dual agents for combined photothermal-radiotherapy of cancer. Nevertheless, the shape effects of gold nanoparticles on photothermal conversion efficiency and radiosensitization have not been completely revealed. To address this knowledge gap, different shapes of gold nanoparticles including gold nanospheres (GNSs), gold nanorods (GNRs), gold nanocages (GNCs) and gold nanoflowers (GNFs) were synthesized. Despite being subjected to the same modification with poly (ethylene glycol) (PEG), these gold nanoparticles showed different cellular uptake efficiencies: GNFs[Formula: see text][Formula: see text][Formula: see text]GNSs[Formula: see text][Formula: see text][Formula: see text]GNCs[Formula: see text][Formula: see text][Formula: see text]GNRs. Moreover, GNRs, GNCs and GNFs could convert near-infrared (NIR) light to heat and GNFs displayed the highest photothermal conversion efficiency, whereas GNSs showed poor photothermal effects due to the weak NIR absorption. The highest uptake efficiency as well as the best photothermal conversion ability led to GNFs to exhibit the best photothermal therapeutic effect. Furthermore, all the gold nanoparticles could be used as radiosensitizers to improve radiotherapeutic effect. Among these nanoparticles, GNFs showed the best radiation enhancement effect because of their highest uptake efficiency. Furthermore, a higher accumulation of GNFs in tumor tissues was observed than those of other shaped gold nanoparticles. Importantly, our in vitro and in vivo comparative studies revealed that GNFs possessed the strongest anticancer effect in combined photothermal-radiotherapy. Hence, compared to gold nanoparticles with other shapes, the GNFs might be more desirable dual agents for highly efficient combined photothermal-radiotherapy.


2020 ◽  
Author(s):  
Maximilian Siller ◽  
Mika Minkkinen ◽  
Pamela Bogust ◽  
Alexander Jelinek ◽  
Jürgen Schatte ◽  
...  

2012 ◽  
Vol 21 (9) ◽  
pp. 097304 ◽  
Author(s):  
Jia Li ◽  
Li Wang ◽  
Zhi-Hong Feng ◽  
Cui Yu ◽  
Qing-Bin Liu ◽  
...  

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