scholarly journals Versatile Ligand-Exchange Method for the Synthesis of Water-Soluble Monodisperse AuAg Nanoclusters for Cancer Therapy

2018 ◽  
Vol 1 (12) ◽  
pp. 6773-6781 ◽  
Author(s):  
Xiaofeng Zan ◽  
Qinzhen Li ◽  
Yiting Pan ◽  
David J. Morris ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Ligand Exchange ◽  
Water Soluble ◽  
Exchange Method

scholarly journals Cadmium-Free Quantum Dots as Fluorescent Labels for Exosomes

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3308 ◽  
Author(s):  
Garima Dobhal ◽  
Deanna Ayupova ◽  
Geoffry Laufersky ◽  
Zeineb Ayed ◽  
Thomas Nann ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cell Line ◽  
Ligand Exchange ◽  
Fluorescent Microscopy ◽  
Fluorescent Labeling ◽  
Water Soluble ◽  
Exchange Method ◽  
Cell Processes ◽  
Monocyte Cell ◽  
Detection Of Biomarkers

Quantum dots are attractive alternatives to organic fluorophores for the purposes of fluorescent labeling and the detection of biomarkers. They can also be made to specifically target a protein of interest by conjugating biomolecules, such as antibodies. However, the majority of the fluorescent labeling using quantum dots is done using toxic materials such as cadmium or lead due to the well-established synthetic processes for these quantum dots. Here, we demonstrate the use of indium phosphide quantum dots with a zinc sulfide shell for the purposes of labeling and the detection of exosomes derived from the THP-1 cell line (monocyte cell line). Exosomes are nano-sized vesicles that have the potential to be used as biomarkers due to their involvement in complex cell processes. However, the lack of standardized methodology around the detection and analysis of exosomes has made it difficult to detect these membrane-containing vesicles. We targeted a protein that is known to exist on the surface of the exosomes (CD63) using a CD63 antibody. The antibody was conjugated to the quantum dots that were first made water-soluble using a ligand-exchange method. The conjugation was done using carbodiimide coupling, and was confirmed using a range of different methods such as dynamic light scattering, surface plasmon resonance, fluorescent microscopy, and Fourier transform infrared spectroscopy. The conjugation of the quantum dot antibody to the exosomes was further confirmed using similar methods. This demonstrates the potential for the use of a non-toxic conjugate to target nano-sized biomarkers that could be further used for the detection of different diseases.

Lead Sulfide Quantum Dot Photodetector with Enhanced Responsivity through a Two-Step Ligand-Exchange Method

2019 ◽  
Vol 2 (10) ◽  
pp. 6135-6143 ◽  
Author(s):  
Haodong Tang ◽  
Jialin Zhong ◽  
Wei Chen ◽  
Kanming Shi ◽  
Guanding Mei ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Lead Sulfide ◽  
Ligand Exchange ◽  
Exchange Method

Localized Surface Plasmon Resonance Effect of Gold Nanoparticles Using 3-Mercaptopropionic Acid as Capping Material for Sensing Probe

2021 ◽  
Vol 891 ◽  
pp. 43-48
Author(s):  
Muhammad Tegar Pambudi ◽  
Suhandoko Dwi Isro ◽  
Priastuti Wulandari
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon Resonance ◽  
Ligand Exchange ◽  
Localized Surface Plasmon Resonance ◽  
Reduction Method ◽  
Colloidal Solution ◽  
Localized Surface Plasmon ◽  
Exchange Method ◽  
Vibrational Peak ◽  
Absorbance Spectra

Gold nanoparticles (AuNP) has been used in a wide range of applications especially in medicine and optoelectronic applications due to its localized surface plasmon resonance (LSPR) effect. LSPR observation of AuNP solution shows that the plasmonic peak in the absorbance spectra lies in the range of visible light around 520 nm with deep red-wine color. The optical characteristic is controlled by the size and shape of the nanoparticles including its surface functionalization. Our research is focused on the adsorption study of 3-mercaptopropionate (3-MP) on AuNP (AuMP) surface synthesized by ligand exchange method and also by direct reduction method. The characterizations are conducted by use of UV-vis and FTIR spectroscopies in order to investigate the effect of LSPR. The absorbance spectra show that both experimental methods of AuMP give a similar profile of red-shifted in the plasmonic peaks in comparison to that of citrate-capped AuNP as a reference from 519 nm to 520 nm. The ligand exchange method of AuMP synthesis results in an unstable colloidal solution after being stored for a week at room temperature while the reduction method results in a stable colloidal solution of AuMP even though it has been stored for 2 months. The FTIR spectra show the difference in vibrational peak intensities between the 3-MP on AuNP and the 3-MPA as reference. The peak of carboxylate (COO-) asymmetric stretching is shifted to low frequency from 1708 cm-1 to 1632 cm-1 indicate the effect of LSPR while the shift to high frequencies for some vibrational peak intensities relates to the strong effect of chemical coordination between gold and capping material. The simulation of the vibration energy by use of the Density Functional Theory (DFT) method shows a similar tendency to that of the peak intensities along the infrared spectrum from experimental results.

Ion Exchange Method for Rapid Determination of Alkalinity of Water-Soluble Tea Ash Containing High Levels of Manganese

1980 ◽  
Vol 63 (3) ◽  
pp. 460-461
Author(s):  
Saidul Z Qureshi ◽  
Fadhil M Najib ◽  
Fahmi A Mohammed
Keyword(s):  
Ion Exchange ◽  
Cation Exchange ◽  
Exchange Resin ◽  
Rapid Determination ◽  
Cation Exchange Resin ◽  
Water Soluble ◽  
Exchange Method ◽  
Strong Cation Exchange ◽  
Ion Exchange Method

Abstract An ion exchange method to determine the alkalinity of water-soluble tea ash containing high levels of manganese is described. A chromatographic column containing a strong cation exchange resin (20–50 mesh) in Na+ form, with a bed volume of 5 mL is used. The present ion exchange method is compared to pH titrations and also to the official AOAC methods (31.012, 31.015, 31.016). Results with the new method are accurate and precise.

Fabrication of water-soluble magnetic nanoparticles by ligand-exchange with thermo-responsive polymers

2009 ◽  
Vol 321 (10) ◽  
pp. 1421-1423 ◽  
Author(s):  
Ian Robinson ◽  
Cameron Alexander ◽  
Le D. Tung ◽  
David G. Fernig ◽  
Nguyen T.K. Thanh
Keyword(s):  
Magnetic Nanoparticles ◽  
Ligand Exchange ◽  
Water Soluble ◽  
Responsive Polymers

A route to robust thioether-functionalized MOF solid materials displaying heavy metal uptake and the ability to be further oxidized

2017 ◽  
Vol 46 (36) ◽  
pp. 12036-12040 ◽  
Author(s):  
Guo-Wei Xiao ◽  
Teng-Fei Chen ◽  
Xin-Zhan Sun ◽  
Hui Guo ◽  
Zhong-Feng Li ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Ligand Exchange ◽  
Metal Uptake ◽  
Alternative Strategy ◽  
Heavy Metal Uptake ◽  
Solid Materials ◽  
Exchange Method

A facile and mild solvent-assisted ligand exchange method was developed as an alternative strategy to achieve thioether-based MOFs, and their oxidized forms, that were able to take up heavy metals from solutions and capture CO2.

scholarly journals Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment

RSC Advances ◽  
2020 ◽  
Vol 10 (42) ◽  
pp. 25290-25304
Author(s):  
Nazanin Bagheri ◽  
Moslem Mansour Lakouraj ◽  
Seyed Reza Nabavi ◽  
Hamed Tashakkorian ◽  
Mojtaba Mohseni
Keyword(s):  
Cancer Therapy ◽  
Polyacrylic Acid ◽  
Anticancer Agent ◽  
Water Soluble ◽  
Acid Copolymer ◽  
Water Soluble Copolymer

In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced.

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