scholarly journals Green-Synthesis-Derived CdS Quantum Dots Using Tea Leaf Extract: Antimicrobial, Bioimaging, and Therapeutic Applications in Lung Cancer Cells

2018 ◽  
Vol 1 (4) ◽  
pp. 1683-1693 ◽  
Author(s):  
Kavitha Shivaji ◽  
Suganya Mani ◽  
Ponnusamy Ponmurugan ◽  
Catherine Suenne De Castro ◽  
Matthew Lloyd Davies ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Quantum Dots ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Leaf Extract ◽  
Lung Cancer Cells ◽  
Cds Quantum Dots ◽  
Therapeutic Applications ◽  
Tea Leaf

Moringa oleifera: Natural leaf extract with potential anti-cancerous effect on A549 lung cancer cells

Lung Cancer ◽  
2012 ◽  
Vol 77 ◽  
pp. S22 ◽  
Author(s):  
M. Dany ◽  
N. Madi ◽  
N. Nemer ◽  
M. Beyrouthy ◽  
S. Abdoun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Lung Cancer Cells ◽  
Natural Leaf ◽  
A549 Lung

Bypassing pro-survival and resistance mechanisms of autophagy in EGFR-positive lung cancer cells by targeted delivery of 5FU using theranostic Ag2S quantum dots

2019 ◽  
Vol 7 (46) ◽  
pp. 7363-7376 ◽  
Author(s):  
Fatma Demir Duman ◽  
Yunus Akkoc ◽  
Gozde Demirci ◽  
Nima Bavili ◽  
Alper Kiraz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Quantum Dots ◽  
Drug Resistance ◽  
Cell Death ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Resistance Mechanisms ◽  
Lung Cancer Cells ◽  
Ag2s Quantum Dots

Cetuximab tagged, 5FU loaded Ag2S QDs enhanced cell death selectively and overcame drug resistance by suppressing autophagy in strong EGFR overexpressing cancer cells.

scholarly journals Anticancer Activity of Leaf Hydro Ethanolic Extract of Aegle marmelos in Human Lung Cancer Cell Mediated through Caspase-3 and Caspase-9 mRNA Expression

2021 ◽  
pp. 336-343
Author(s):  
R. Sukanth ◽  
G. Sridevi ◽  
J. Selvaraj ◽  
S. Preetha
Keyword(s):  
Lung Cancer ◽  
Mrna Expression ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Leaf Extract ◽  
Caspase 3 ◽  
Fold Change ◽  
Lung Cancer Cells ◽  
Aegle Marmelos ◽  
Caspase 9

Background: Aegle marmelos (AE) is a medicinal plant that comes under the rutaceae family and the plant was used in the past for treating many diseases and illness symptoms. The plant has many effects such as anti-diarrhoeal, antimicrobial, antiviral, radioprotective, anticancer, chemopreventive, antipyretic, ulcer healing, antigenotoxic, diuretic, antifertility and anti-inflammatory properties. Aim: To know the anticancer activity of hydroethanolic leaf extract of Aegle marmelos over lung cancer cells treated with caspase 3 and caspase 9 mRNA expression. Materials and Methods: The required chemicals were collected mainly from Canada. The lung cancer cells (A549) were collected from NCCS pune and then RNA was extracted from the cells and then the study was conducted after treating it with caspase 3 and caspase 9 mRNA expression. The cells were treated with many dosage of hydroethanolic extract of Aegle marmelos and the cell viability was noted. Results: The study reported that extract of Aegle marmelos has a great anticancer activity about 1 fold change over rate of 1.7 for cells treated with caspase 3 and a fold change over of 1 in caspase 9 treated lung cancer cells. Conclusion: The study concluded an innovative finding that the hydroethanolic leaf extract of Aegle marmelos has a great anticancer activity against lung cancer cells treated with caspase 3 and caspase 9 mRNA expression.

A recognition-before-labeling strategy for sensitive detection of lung cancer cells with a quantum dot–aptamer complex

The Analyst ◽  
2015 ◽  
Vol 140 (17) ◽  
pp. 6100-6107 ◽  
Author(s):  
Chunlei Wu ◽  
Jianbo Liu ◽  
Pengfei Zhang ◽  
Jing Li ◽  
Haining Ji ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Quantum Dots ◽  
Quantum Dot ◽  
Cancer Cells ◽  
Steric Hindrance ◽  
Sensitive Detection ◽  
Lung Cancer Cells ◽  
Recognition Elements

A recognition-before-labeling strategy is developed for sensitive detection of A549 cancer cells, by using fluorescent quantum dots as signal units and aptamers as recognition elements, which avoided the possible impact on the aptamer configuration from steric hindrance.

MicroRNA‐mediated suppression of P‐glycoprotein by quantum dots in lung cancer cells

2019 ◽  
Vol 40 (4) ◽  
pp. 525-534 ◽  
Author(s):  
Yimin Sun ◽  
Jie Zhang ◽  
Huancai Yin ◽  
Jian Yin
Keyword(s):  
Lung Cancer ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
P Glycoprotein

scholarly journals Correction to: Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Monika Ruzycka-Ayoush ◽  
Patrycja Kowalik ◽  
Agata Kowalczyk ◽  
Piotr Bujak ◽  
Anna M. Nowicka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

2020 ◽  
Author(s):  
Monika Ruzycka ◽  
Patrycja Kowalik ◽  
Agata Kowalczyk ◽  
Piotr Bujak ◽  
Anna M. Nowicka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Dna Breaks ◽  
Folate Receptors

Abstract Background Lung cancer is one of the most frequently diagnosed cancer all over the world and a leading cancer-related mortality. The therapy of lung cancer includes surgery, chemotherapy and radiatherapy and mailny depends on the type and stage of lung cancer characterized based on WHO guidelines. Althought the conventional chemotherapy is the main treatment option for small cell lung cancer (SCLC) and a common treatment for non-SCLC it is characterized with lack of specificity resulting to severe toxicities of normal cells and harmful side effects. Therefore, targeted drug delivery (TDD) systems have been used to reduce the systemic toxicity of some conventional chemotherapies in lung cancer. Quantum dots (QDs) are fascinating nanoscale crystals that can serve as nanocarriers in TDD due to their unique physicochemical properties. Therefore, in this paper, the as-desiged QDs, Ag-In-Zn-S-based nanoconjugates for selective doxorubicin (DOX) targeting to lung cancer cells were developed. The QD nanocrystals were modified with 11-mercaptoundecanoic acid (MUA), L-cysteine (Cys) and lipoic acid (LA) used as drug carriers for targeted delivery of DOX to A549 cells through conjugated folic acid (FA) a self-navigation molecule that docks to the folate receptors on cancer cells. The comprechensive physicochemical, cytotoxicity and genotoxicity studies were performed to characterise the novel QD-based nanocaries and their anticancer cargos. Results The results from FTIR, DLS and fluorescence quenching evidenced the successful attachment of FA to the QDs nanocrystals and DOX to the QDs-FA nanocarriers. UV-vis analysis determined the amount of FA and DOX covalently anchored to the QDs nanocrystal surface. Biological screeining revealed that QDs-FA-DOX nanoconjugates showed higher cytotoxicity in comparison to other forms of the synthesized QD samples, suggesting the cytotoxic effect of liberated DOX from the QD constructs. QD-MUA-FA-DOX occurred to be the most cytotoxic against A549 cells among nanoconjugates. In vitro scratch assay also revealed significant inhibition of A549 migration only due to treatment with QD-MUA-FA-DOX. Studies evidenced that all the nanoconjugates at IC 50 induced significantly more DNA breaks than that observed in non-treated cells. All in all, significant and the greatest cytotoxicity, genotoxicity together with inhibition of migratory potential of A549 cells was observed for QD-MUA-FA-DOX. Conclusion The studies show the therapeutic efficacy of DOX-loaded QD-based cargos suggesting their promising role as novel drug delivery systems navigating to folate receptors in lung cancer cells.

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