Doped Plasmonic Zinc Oxide Nanoparticles with Near-Infrared Absorption for Antitumor Activity

Author(s):  
Nathalia Cristina Rissi ◽  
Edson J. Comparetti ◽  
Bianca Martins Estevão ◽  
Valmor Roberto Mastelaro ◽  
Valtencir Zucolotto
RSC Advances ◽  
2014 ◽  
Vol 4 (81) ◽  
pp. 42758-42763 ◽  
Author(s):  
Haifeng Zhou ◽  
Hua Wang ◽  
Kang Zheng ◽  
Zhen Gu ◽  
Zhaofeng Wu ◽  
...  

Aluminum-doped ZnO nanoparticles with tunable NIR absorption.


2012 ◽  
pp. 3203 ◽  
Author(s):  
Seok Tae Lim ◽  
Hwan jeong Jeong ◽  
Dong Wook Kim ◽  
Seok Tae Lim ◽  
Myung Hee Sohn ◽  
...  

Tumor Biology ◽  
2020 ◽  
Vol 42 (3) ◽  
pp. 101042832090999 ◽  
Author(s):  
Asmaa I Nabeel

Cancer is the leading cause of death and exhausts human and economic resources for treatment and protection. Zinc oxide nanoparticles play an effective role in tumor treatment but with some cautions, such as overexpression of cytochrome P450, hepatic overload, and the mammalian target of rapamycin pathway resistance. Although lanthanides have antitumor activity, their use is limited. Therefore, the current study aims to improve the effectiveness of zinc oxide nanoparticle via doping with lanthanides, such as samarium. In vitro study revealed that samarium doped with zinc oxide showed more antitumor activity than the other lanthanides, and the antitumor activity depends on the concentration of samarium in the nanocomposite. The in vivo experiment on mice bearing Ehrlich solid tumor revealed that intramuscular injection of samarium/zinc oxide downregulates the expressions of CXCR4 and PI3K/Akt/mammalian target of rapamycin pathway in respect to Ehrlich solid tumor group. Regarding the apoptotic biomarkers, samarium/zinc oxide upregulates the apoptotic biomarker; Bax accompanied with the mitotic catastrophe which was indicated by cell cycle arrest in G2 phase. Moreover, samarium:zinc oxide nanoparticles exhibited minimum toxicity which was indicated by suppressed activities of cytochrome P450 and hepatic enzymes, including alanine transaminase and aspartate transaminase. In addition, the histopathological finding, as well as immunophenotyping results, appreciated the biochemical finding. Therefore, samarium:zinc oxide might be offered a new approach to improve the effectiveness of zinc oxide nanoparticles along with lower toxic effect. Also, samarium:zinc oxide nanoparticles can be a candidate as a new antitumor compound to detect its mode of action.


2014 ◽  
Vol 1 (4) ◽  
pp. 045022 ◽  
Author(s):  
Haifeng Zhou ◽  
Hua Wang ◽  
Xingyou Tian ◽  
Kang Zheng ◽  
Fei Xu ◽  
...  

Author(s):  
Stephan Hackenberg ◽  
Agmal Scherzed ◽  
Wilma Harnisch ◽  
Katrin Froelich ◽  
Christian Ginzkey ◽  
...  

2014 ◽  
Vol 29 (10) ◽  
pp. 1039
Author(s):  
TAN Man-Lin ◽  
WANG Yan-Tao ◽  
ZHANG Wei-Li ◽  
FU Dong-Ju ◽  
LI Dong-Shuang ◽  
...  

Author(s):  
Hams H. H. Alfattli ◽  
Ghufran Zuhair Jiber ◽  
Ghaidaa Gatea Abbass

This study which designed to evaluate the inhibitory effect of Ethanolic extract of (Quercusrobur) and Zinc oxide nanoparticles on the growth of one genus of enterobacteriacae (Salmonella). In vitro. For this purpose graduate concentrates for plant extract (50, 100, 200, 400 )mg/ml which prepared and compared with Zinc oxide nanoparticles of different concentration (2, 1, 0.5, 0.25) μg/ml,and examined. The result showed that the studied medicinal plant has antibacterial activity against this bacteria which used. The result showed that the plant has good activity in decrease the growth of this bacteria. The results of the study also showed that the nano-ZnO has very effective antibacterial action against the studied bacteria which was Salmonella,nanoparticles concentrations lead to increasing in the inhibition zones of tested bacterial growth. We also study the effect of three antibiotics Lomefloxacin (LOM), Ciprofloxacin (SIP) and Rifampin (RA) and the result showed,in a comparison within the tested bacteria,Salmonella had a significant inhibition increase in Lomefloxacin ; the ciprofloxacin showed effect on tested bacteria. However,Rifampin does not show any effect on tested bacteria.


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