Prussian Blue Nanoparticles Having Various Sizes and Crystallinities for Multienzyme Catalysis and Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Kaizheng Feng ◽  
Jing Zhang ◽  
Haijiao Dong ◽  
Zhuoxuan Li ◽  
Ning Gu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Prussian Blue ◽  
Resonance Imaging ◽  
Prussian Blue Nanoparticles

scholarly journals In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

2012 ◽  
Vol 10 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Javier Bustamante Mamani ◽  
Jackeline Moraes Malheiros ◽  
Ellison Fernando Cardoso ◽  
Alberto Tannús ◽  
Paulo Henrique Silveira ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Tumor Growth ◽  
Prussian Blue ◽  
Superparamagnetic Iron Oxide ◽  
C6 Glioma Cells ◽  
C6 Cells ◽  
Resonance Imaging

OBJECTIVE: The aim of the current study was to monitor the migration of superparamagnetic iron oxide nanoparticle (SPION)-labeled C6 cells, which were used to induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (MRI), with the goal of aiding in tumor prognosis and therapy. METHODS: Two groups of male Wistar rats were used for the tumor induction model. In the first group (n=3), the tumors were induced via the injection of SPION-labeled C6 cells. In the second group (n=3), the tumors were induced via the injection of unlabeled C6 cells. Prussian Blue staining was performed to analyze the SPION distribution within the C6 cells in vitro. Tumor-inducing C6 cells were injected into the right frontal cortex, and subsequent tumor monitoring and SPION detection were performed using T2- and T2*-weighted MRI at a 2T field strength. In addition, cancerous tissue was histologically analyzed after performing the MRI studies. RESULTS: The in vitro qualitative evaluation demonstrated adequate distribution and satisfactory cell labeling of the SPIONs. At 14 or 21 days after C6 injection, a SPION-induced T2- and T2*-weighted MRI signal reduction was observed within the lesion located in the left frontal lobe on parasagittal topography. Moreover, histological staining of the tumor tissue with Prussian Blue revealed a broad distribution of SPIONs within the C6 cells. CONCLUSION: MRI analyses exhibit potential for monitoring the tumor growth of C6 cells efficiently labeled with SPIONs.

MnII-containing coordination nanoparticles as highly efficient T1 contrast agents for magnetic resonance imaging

2014 ◽  
Vol 50 (51) ◽  
pp. 6740-6743 ◽  
Author(s):  
Gabriella Paul ◽  
Yoann Prado ◽  
Nada Dia ◽  
Eric Rivière ◽  
Sophie Laurent ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Prussian Blue ◽  
Resonance Imaging ◽  
Prussian Blue Analogues ◽  
Highly Efficient ◽  
T1 Contrast

Nanoparticles of MnII-containing Prussian blue analogues reveal large longitudinal relaxivities exceeding that of clinical contrast agents.

scholarly journals Magnetic Resonance Imaging of Transplanted Porcine Neonatal Pancreatic Cell Clusters Labeled with Chitosan-Coated Superparamagnetic Iron Oxide Nanoparticles in Mice

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1238
Author(s):  
Jyuhn-Huarng Juang ◽  
Jiun-Jie Wang ◽  
Chia-Rui Shen ◽  
Chen-Yi Chen ◽  
Chen-Wei Kao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Prussian Blue ◽  
Superparamagnetic Iron Oxide ◽  
Blue Staining ◽  
Resonance Imaging ◽  
Pancreatic Cell ◽  
Cell Clusters ◽  
Prussian Blue Staining

Neonatal pancreatic cell clusters (NPCCs) are potential tissues for the treatment of diabetes. Different from adult cells, they continuously proliferate and differentiate after transplantation. In this study, we utilized magnetic resonance imaging (MRI) to detect and monitor implanted NPCCs. NPCCs were isolated from one-day-old neonatal pigs, cultured for three days, and then incubated overnight with the contrast agent chitosan-coated superparamagnetic iron oxide (CSPIO) nanoparticles. In vitro, Prussian blue staining and MR scans of CSPIO-labeled NPCCs were performed. In vivo, we transplanted 2000 CSPIO-labeled NPCCs under the kidney capsule of nondiabetic nude mice. Recipients were scanned with 7.0T MRI. Grafts were removed for histology with insulin and Prussian blue staining. After being incubated overnight with CSPIO, NPCCs showed positive iron staining and appeared as dark spots on MR scans. After transplantation of CSPIO-labeled NPCCs, persistent hypointense areas were observed at recipients’ implant sites for up to 54 days. Moreover, histology showed colocalization of the insulin and iron staining in 15-, 51- and 55-day NPCC grafts. Our results indicate that transplanted NPCCs survived and differentiated to β cells after transplantation, and that MRI is a useful tool for the detection and monitoring of CSPIO-labeled NPCC grafts.

Tailoring magnetic resonance imaging relaxivities in macroporous Prussian blue cubes

2019 ◽  
Vol 48 (31) ◽  
pp. 11882-11888 ◽  
Author(s):  
Wenlan Guan ◽  
Ji Ma ◽  
Xi Peng ◽  
Kezheng Chen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Zeta Potential ◽  
Contrast Agents ◽  
Prussian Blue ◽  
Resonance Imaging ◽  
The Relationship

In order to unravel the relationship between zeta potential values and r2/r1 ratios for contrast agents in MRI application, a series of macroporous Prussian blue cubes were successfully synthesized by HCl etching and used as model samples for relaxivity investigation.

Sign in / Sign up

Export Citation Format

Share Document