Quaternized Starch-Based Composite Nanoparticles for siRNA Delivery to Tumors

2021 ◽  
Vol 4 (2) ◽  
pp. 2218-2229
Author(s):  
Eliz Amar-Lewis ◽  
Nitsa Buaron ◽  
Ramesh Chintakunta ◽  
Chen Benafsha ◽  
Riki Goldbart ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Composite Nanoparticles

Polymersomes-mediated siRNA delivery for states of hormone excess

2013 ◽  
pp. 1-1
Author(s):  
Georgia Bakirtzi ◽  
Giuseppe Battaglia ◽  
Giuseppe Battaglia ◽  
John Price Newell
Keyword(s):  
Sirna Delivery

Magnetic Properties of Fe3O4/CoFe2O4 Composite Nanoparticles with Core/Shell Architecture

2020 ◽  
Vol 65 (10) ◽  
pp. 904
Author(s):  
V. O. Zamorskyi ◽  
Ya. M. Lytvynenko ◽  
A. M. Pogorily ◽  
A. I. Tovstolytkin ◽  
S. O. Solopan ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Spinel Ferrite ◽  
Composite Nanoparticles ◽  
Core Shell ◽  
Cofe2o4 Nanoparticles ◽  
Core Diameter ◽  
The Core ◽  
Shell Particles ◽  
Interface Parameters ◽  
Shell Composite

Magnetic properties of the sets of Fe3O4(core)/CoFe2O4(shell) composite nanoparticles with a core diameter of about 6.3 nm and various shell thicknesses (0, 1.0, and 2.5 nm), as well as the mixtures of Fe3O4 and CoFe2O4 nanoparticles taken in the ratios corresponding to the core/shell material contents in the former case, have been studied. The results of magnetic research showed that the coating of magnetic nanoparticles with a shell gives rise to the appearance of two simultaneous effects: the modification of the core/shell interface parameters and the parameter change in both the nanoparticle’s core and shell themselves. As a result, the core/shell particles acquire new characteristics that are inherent neither to Fe3O4 nor to CoFe2O4. The obtained results open the way to the optimization and adaptation of the parameters of the core/shell spinel-ferrite-based nanoparticles for their application in various technological and biomedical domains.

Lipid-based siRNA Delivery Systems

2012 ◽  
Vol 39 (5) ◽  
pp. 396-401 ◽  
Author(s):  
Wen-Juan DONG ◽  
Yin-Jian ZHOU ◽  
Wei LIANG
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems

Multifunctional Superparamagnetic Nanoparticles: From Synthesis to siRNA Delivery

2017 ◽  
Vol 23 (16) ◽  
Author(s):  
Sanam Arami ◽  
Majid Mahdavi ◽  
Mohammad Reza Rashidi ◽  
Marziyeh Fathi ◽  
Mohammad Saeid Hejazi ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Superparamagnetic Nanoparticles

Stimuli-Responsive Nanoparticles for siRNA Delivery

2015 ◽  
Vol 21 (29) ◽  
pp. 4131-4144 ◽  
Author(s):  
Josimar Eloy ◽  
Raquel Petrilli ◽  
Renata Lopez ◽  
Robert Lee
Keyword(s):  
Sirna Delivery ◽  
Stimuli Responsive

Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers

2018 ◽  
Vol 24 (16) ◽  
pp. 1788-1800 ◽  
Author(s):  
Kye-Soo Cho ◽  
Seo-Jin Hong ◽  
Min-Hye Ahn ◽  
Sukdeb Pal ◽  
Pill-Hoon Choung ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Delivery System ◽  
Targeted Delivery ◽  
Sirna Delivery ◽  
Public Health Issue ◽  
Magic Bullet ◽  
Bodily Fluids ◽  
Low Cytotoxicity ◽  
Genetic And Environmental Factors ◽  
Sirna Delivery System

Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising and novel agents is the siRNA delivery system; however, poor cellular uptake and altered siRNA stability in physiological environments have limited its use in clinical trials. Therefore, developing the ideal siRNA delivery system with low cytotoxicity, improved siRNA stability in the body’s circulation, and prevention of its rapid clearance from bodily fluids, is rapidly emerging as an innovative therapeutic strategy to combat cancer. Moreover, active targeting using ligand moieties which bind to over-expressed receptors on the surface of cancer cells would enhance the therapeutic efficiency of siRNA. Conclusion: In this review, we provide 1) an overview of the non-viral carrier associated with siRNA delivery for cancer treatment, and 2) a description of the five major cancer-targeting ligands.

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