scholarly journals Carbon Nanotube–Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation

2020 ◽  
Author(s):  
S. Zahra M. Madani ◽  
Mohammad Moein Safaee ◽  
Mitchell Gravely ◽  
Carolynn Silva ◽  
Stephen Kennedy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carbon Nanotube ◽  
Near Infrared ◽  
Controlled Drug Delivery ◽  
Infrared Laser ◽  
Laser Stimulation

Thermo-sensitive liposomes loaded with doxorubicin and lysine modified single-walled carbon nanotubes as tumor-targeting drug delivery system

2014 ◽  
Vol 29 (5) ◽  
pp. 769-779 ◽  
Author(s):  
Xiali Zhu ◽  
Yingxia Xie ◽  
Yingjie Zhang ◽  
Heqing Huang ◽  
Shengnan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carbon Nanotube ◽  
Laser Irradiation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Infrared Laser ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Infrared Laser Irradiation

This report focuses on the thermo-sensitive liposomes loaded with doxorubicin and lysine-modified single-walled carbon nanotube drug delivery system, which was designed to enhance the anti-tumor effect and reduce the side effects of doxorubicin. Doxorubicin-lysine/single-walled carbon nanotube-thermo-sensitive liposomes was prepared by reverse-phase evaporation method, the mean particle size was 232.0 ± 5.6 nm, and drug entrapment efficiency was 86.5 ± 3.7%. The drug release test showed that doxorubicin released more quickly at 42℃ than at 37℃. Compared with free doxorubicin, doxorubicin-lysine/single-walled carbon nanotube-thermo-sensitive liposomes could efficiently cross the cell membranes and afford higher anti-tumor efficacy on the human hepatic carcinoma cell line (SMMC-7721) cells in vitro. For in vivo experiments, the relative tumor volumes of the sarcomaia 180-bearing mice in thermo-sensitive liposomes group and doxorubicin group were significantly smaller than those of N.S. group. Meanwhile, the combination of near-infrared laser irradiation at 808 nm significantly enhanced the tumor growth inhibition both on SMMC-7721 cells and the sarcomaia 180-bearing mice. The quality of life such as body weight, mental state, food and water intake of sarcomaia 180 tumor-bearing mice treated with doxorubicin-lysine/single-walled carbon nanotube-thermo-sensitive liposomes were much higher than those treated with doxorubicin. In conclusion, doxorubicin-lysine/single-walled carbon nanotube-thermo-sensitive liposomes combined with near-infrared laser irradiation at 808 nm may potentially provide viable clinical strategies for targeting delivery of anti-cancer drugs.

A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3811-3825 ◽  
Author(s):  
Panchanathan Manivasagan ◽  
Seung Won Jun ◽  
Van Tu Nguyen ◽  
Nguyen Thanh Phong Truong ◽  
Giang Hoang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Combination Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Chitosan Oligosaccharide

FA–COS–TGA–GNRs–DOX have been successfully designed as a drug delivery system for chemo-photothermal combination therapy.

scholarly journals Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs

2016 ◽  
Vol 20 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Tian Guan ◽  
Jian Wang ◽  
Muqun Yang ◽  
Kai Zhu ◽  
Yong Wang ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Guinea Pigs ◽  
Near Infrared ◽  
Infrared Laser ◽  
Laser Stimulation ◽  
Stimulation Of

scholarly journals Impact of heat on metabolic and hemodynamic changes in transcranial infrared laser stimulation measured by broadband near-infrared spectroscopy

2017 ◽  
Vol 5 (01) ◽  
pp. 1 ◽  
Author(s):  
Xinlong Wang ◽  
Divya D. Reddy ◽  
Sahil S. Nalawade ◽  
Suvra Pal ◽  
F. Gonzalez-Lima ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Hemodynamic Changes ◽  
Laser Stimulation

Fabrication of Plasmonic Nanorod-Embedded Dipeptide Microspheres via the Freeze-Quenching Method for Near-Infrared Laser-Triggered Drug-Delivery Applications

2016 ◽  
Vol 17 (5) ◽  
pp. 1788-1794 ◽  
Author(s):  
Hakan Erdogan ◽  
Mehmet Yilmaz ◽  
Esra Babur ◽  
Memed Duman ◽  
Halil M. Aydin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Infrared Laser ◽  
Drug Delivery Applications ◽  
Quenching Method

scholarly journals Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study

2017 ◽  
Vol 37 (12) ◽  
pp. 3789-3802 ◽  
Author(s):  
Xinlong Wang ◽  
Fenghua Tian ◽  
Divya D Reddy ◽  
Sahil S Nalawade ◽  
Douglas W Barrett ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared Spectroscopy ◽  
Time Course ◽  
Near Infrared ◽  
Cerebral Metabolism ◽  
Infrared Laser ◽  
Cortical Region ◽  
Laser Stimulation

Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered 1064-nm laser stimulation to the forehead of healthy participants ( n = 11), while broadband near-infrared spectroscopy was utilized to acquire light reflectance from the TILS-treated cortical region before, during, and after TILS. Placebo experiments were also performed for accurate comparison. Time course of spectroscopic readings were analyzed and fitted to the modified Beer–Lambert law. With respect to the placebo readings, we observed (1) significant increases in cerebral concentrations of oxidized CCO (Δ[CCO]; >0.08 µM; p < 0.01), oxygenated hemoglobin (Δ[HbO]; >0.8 µM; p < 0.01), and total hemoglobin (Δ[HbT]; >0.5 µM; p < 0.01) during and after TILS, and (2) linear interplays between Δ[CCO] versus Δ[HbO] and between Δ[CCO] versus Δ[HbT]. Ratios of Δ[CCO]/Δ[HbO] and Δ[CCO]/Δ[HbT] were introduced as TILS-induced metabolic-hemodynamic coupling indices to quantify the coupling strength between TILS-enhanced cerebral metabolism and blood oxygen supply. This study provides the first demonstration that TILS causes up-regulation of oxidized CCO in the human brain, and contributes important insight into the physiological mechanisms.

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