Quaternized Cationic Carbon Dots as Antigen Delivery Systems for Improving Humoral and Cellular Immune Responses

2020 ◽  
Vol 3 (9) ◽  
pp. 9449-9461 ◽  
Author(s):  
Shaomei Huang ◽  
Bowen Li ◽  
Usama Ashraf ◽  
Qi Li ◽  
Xingchang Lu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Carbon Dots ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Cellular Immune Responses ◽  
Cellular Immune ◽  
Antigen Delivery Systems

Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo

2016 ◽  
Vol 4 (33) ◽  
pp. 5608-5620 ◽  
Author(s):  
Pan Li ◽  
Gaona Shi ◽  
Xiuyuan Zhang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Protein Antigen ◽  
Antigen Delivery ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Immune Adjuvants ◽  
Cationic Nanoparticles ◽  
Antigen Delivery Systems

Guanidinylated nanoparticles could act as effective immune adjuvants to elicit both potent antigen-specific cellular and humoral immune responses.

An aluminum adjuvant-integrated nano-MOF as antigen delivery system to induce strong humoral and cellular immune responses

2019 ◽  
Vol 300 ◽  
pp. 81-92 ◽  
Author(s):  
Xiaofang Zhong ◽  
Yunting Zhang ◽  
Lu Tan ◽  
Tao Zheng ◽  
Yingying Hou ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Antigen Delivery ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 972
Author(s):  
Abu Salim Mustafa
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immune Responses ◽  
Pulmonary Disease ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Special Issue ◽  
Subunit Vaccines ◽  
Recombinant Bcg ◽  
New Vaccines ◽  
Antigen Delivery Systems

The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults. Furthermore, the use of BCG is contraindicated in immunocompromised subjects. The research towards the development of new vaccines against TB includes the use of Mycobacterium tuberculosis antigens as subunit vaccines. Such vaccines may be used either alone or in the prime-boost model in BCG-vaccinated people. However, the antigens for subunit vaccines require adjuvants and/or delivery systems to induce appropriate and protective immune responses against tuberculosis and other diseases. Articles published in this Special Issue have studied the pathogenesis of BCG in children and the use of BCG and recombinant BCG as potential vaccines against asthma. Furthermore, the use of different adjuvants and delivery systems in inducing the protective immune responses after immunization with subunit vaccines has been described.

scholarly journals A Review of Intra- and Extracellular Antigen Delivery Systems for Virus Vaccines of Finfish

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
Hetron Mweemba Munang’andu ◽  
Øystein Evensen
Keyword(s):  
Immune Responses ◽  
Adaptive Immune Response ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Mhc I ◽  
Mhc Ii ◽  
Adaptive Immune ◽  
Long Time ◽  
T Cell Immune Responses ◽  
Antigen Delivery Systems

Vaccine efficacy in aquaculture has for a long time depended on evaluating relative percent survival and antibody responses after vaccination. However, current advances in vaccine immunology show that the route in which antigens are delivered into cells is deterministic of the type of adaptive immune response evoked by vaccination. Antigens delivered by the intracellular route induce MHC-I restricted CD8+ responses while antigens presented through the extracellular route activate MHC-II restricted CD4+ responses implying that the route of antigen delivery is a conduit to induction of B- or T-cell immune responses. In finfish, different antigen delivery systems have been explored that include live, DNA, inactivated whole virus, fusion protein, virus-like particles, and subunit vaccines although mechanisms linking these delivery systems to protective immunity have not been studied in detail. Hence, in this review we provide a synopsis of different strategies used to administer viral antigens via the intra- or extracellular compartments. Further, we highlight the differences in immune responses induced by antigens processed by the endogenous route compared to exogenously processed antigens. Overall, we anticipate that the synopsis put together in this review will shed insights into limitations and successes of the current vaccination strategies used in finfish vaccinology.

scholarly journals Correction: Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo

2016 ◽  
Vol 4 (41) ◽  
pp. 6746-6747
Author(s):  
Pan Li ◽  
Gaona Shi ◽  
Xiuyuan Zhang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Protein Antigen ◽  
Antigen Delivery ◽  
Cationic Nanoparticles ◽  
Antigen Delivery Systems

Correction for ‘Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo’ by Pan Li et al., J. Mater. Chem. B, 2016, 4, 5608–5620.

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

2010 ◽  
Vol 147 (3) ◽  
pp. 342-349 ◽  
Author(s):  
Deepa Mohanan ◽  
Bram Slütter ◽  
Malou Henriksen-Lacey ◽  
Wim Jiskoot ◽  
Joke A. Bouwstra ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Cross Sectional ◽  
Administration Routes ◽  
Particulate Antigen ◽  
Antigen Delivery Systems

scholarly journals Immunopotentiating and Delivery Systems for HCV Vaccines

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 981
Author(s):  
Alexander K. Andrianov ◽  
Thomas R. Fuerst
Keyword(s):  
Immune Responses ◽  
Self Assembly ◽  
Delivery Systems ◽  
Cellular Immune Responses ◽  
Current State ◽  
Physico Chemical ◽  
Vaccine Antigens ◽  
Assembly Behavior ◽  
Cellular Immune

Development of preventive vaccines against hepatitis C virus (HCV) remains one of the main strategies in achieving global elimination of the disease. The effort is focused on the quest for vaccines capable of inducing protective cross-neutralizing humoral and cellular immune responses, which in turn dictate the need for rationally designed cross-genotype vaccine antigens and potent immunoadjuvants systems. This review provides an assessment of the current state of knowledge on immunopotentiating compounds and vaccine delivery systems capable of enhancing HCV antigen-specific immune responses, while focusing on the synergy and interplay of two modalities. Structural, physico-chemical, and biophysical features of these systems are discussed in conjunction with the analysis of their in vivo performance. Extreme genetic diversity of HCV-a well-known hurdle in the development of an HCV vaccine, may also present a challenge in a search for an effective immunoadjuvant, as the effort necessitates systematic and comparative screening of rationally designed antigenic constructs. The progress may be accelerated if the preference is given to well-defined molecular immunoadjuvants with greater formulation flexibility and adaptability, including those capable of spontaneous self-assembly behavior, while maintaining their robust immunopotentiating and delivery capabilities.

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