Synthesis and Self-Assembly of Hydroxypropyl Methyl Cellulose-block-Poly(ε-caprolactone) Copolymers as Nanocarriers of Lipophilic Drugs

2020 ◽  
Vol 3 (5) ◽  
pp. 4367-4375 ◽  
Author(s):  
Aijing Lu ◽  
Eddy Petit ◽  
Yuandou Wang ◽  
Feng Su ◽  
Suming Li
Keyword(s):  
Self Assembly ◽  
Methyl Cellulose ◽  
Lipophilic Drugs ◽  
Hydroxypropyl Methyl Cellulose

scholarly journals Synthesis and self-assembly of AB2-type amphiphilic copolymers from biobased hydroxypropyl methyl cellulose and poly(L-lactide)

2019 ◽  
Vol 211 ◽  
pp. 133-140 ◽  
Author(s):  
Aijing Lu ◽  
Jielin Wang ◽  
Marleny Caceres Najarro ◽  
Suming Li ◽  
Andre Deratani
Keyword(s):  
Self Assembly ◽  
Methyl Cellulose ◽  
Amphiphilic Copolymers ◽  
Hydroxypropyl Methyl Cellulose

scholarly journals Manipulation of the Glass Transition Properties of a High-Solid System Made of Acrylic Acid-N,N′-Methylenebisacrylamide Copolymer Grafted on Hydroxypropyl Methyl Cellulose

2021 ◽  
Vol 22 (5) ◽  
pp. 2682
Author(s):  
Nazim Nassar ◽  
Felicity Whitehead ◽  
Taghrid Istivan ◽  
Robert Shanks ◽  
Stefan Kasapis
Keyword(s):  
Glass Transition ◽  
Acrylic Acid ◽  
Methyl Cellulose ◽  
Small Deformation ◽  
Polymerization Reaction ◽  
Solid Matrix ◽  
Scanning Calorimetry ◽  
Modulated Differential Scanning Calorimetry ◽  
High Solid ◽  
Hydroxypropyl Methyl Cellulose

Crosslinking of hydroxypropyl methyl cellulose (HPMC) and acrylic acid (AAc) was carried out at various compositions to develop a high-solid matrix with variable glass transition properties. The matrix was synthesized by the copolymerisation of two monomers, AAc and N,N′-methylenebisacrylamide (MBA) and their grafting onto HMPC. Potassium persulfate (K2S2O8) was used to initiate the free radical polymerization reaction and tetramethylethylenediamine (TEMED) to accelerate radical polymerisation. Structural properties of the network were investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), modulated differential scanning calorimetry (MDSC), small-deformation dynamic oscillation in-shear, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The results show the formation of a cohesive macromolecular entity that is highly amorphous. There is a considerable manipulation of the rheological and calorimetric glass transition temperatures as a function of the amount of added acrylic acid, which is followed upon heating by an extensive rubbery plateau. Complementary TGA work demonstrates that the initial composition of all the HPMC-AAc networks is maintained up to 200 °C, an outcome that bodes well for applications of targeted bioactive compound delivery.

Evaluation of Hydroxypropyl Cellulose and Hydroxypropyl Methyl Cellulose as Aqueous Based Film Coatings

1981 ◽  
Vol 7 (6) ◽  
pp. 693-716 ◽  
Author(s):  
Gilbert Banker ◽  
Garnet Peck ◽  
Steve Ja ◽  
Pichai Pirakitikulr ◽  
Deeni Taylor
Keyword(s):  
Methyl Cellulose ◽  
Hydroxypropyl Cellulose ◽  
Hydroxypropyl Methyl Cellulose ◽  
Film Coatings

scholarly journals Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets

2018 ◽  
Vol 16 (1) ◽  
pp. 333-339
Author(s):  
Wanying Liu ◽  
Qing Huo ◽  
Yue Wang ◽  
Na Yu ◽  
Rongjian Shi
Keyword(s):  
Sustained Release ◽  
Diffusion Mechanism ◽  
Methyl Cellulose ◽  
Magnesium Stearate ◽  
Test Method ◽  
Release Mechanism ◽  
Hydroxypropyl Methyl Cellulose ◽  
Hypolipidemic Agents ◽  
Sustained Release Tablets ◽  
The Difference

AbstractIn this study, we investigate the production of hypolipidemic agents in the form of Acipimox sustained-release tablets, using a wet pelleting process. The purpose of this research is to reduce the total intake time for patients and to lower the initial dose in such that the adverse reactions could be reduced. This study adopts the single-factor method and orthogonal experiments by using hydroxypropyl methyl cellulose (HPMC K15M) as the main sustained-release prescription composition. The final prescription is Acipimox 20%, HPMC K15M 26.67%, sodium carboxymethyl cellulose 30%, polyethylene glycol (PEG 6000) 1%, ethyl cellulose 16.6%, lactose 4.67% and magnesium stearate 1%. The dissolution of tablets reached 85.88% in 8 h. The difference in the weight, hardness and friability of the tables met the requirements in the Chinese Pharmacopoeia; to test the stability, a temperature and illumination accelerated test method was used, the results indicate that the Acipimox sustained-release tablets should be sealed and stored in a dark, cool area. A preliminary study on the tablets’ releasing mechanism showed that their release curve fitted the Higuchi model (the formula is Mt/M∞ = 31.137 t1/2–3.605 (R2 = 0.9903)). The Acipimox tablets’ release principle is dominated by the diffusion mechanism.

Preparation and characterization of silk fibroin/hydroxypropyl methyl cellulose (HPMC) blend films

2015 ◽  
Vol 16 (8) ◽  
pp. 1734-1741 ◽  
Author(s):  
G. Rajesha Shetty ◽  
B. Lakshmeesha Rao ◽  
S. Asha ◽  
Youjiang Wang ◽  
Y. Sangappa
Keyword(s):  
Silk Fibroin ◽  
Methyl Cellulose ◽  
Hydroxypropyl Methyl Cellulose ◽  
Blend Films
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