Automated, Universal, and Mass-Producible Paper-Based Lateral Flow Biosensing Platform for High-Performance Point-of-Care Testing

2019 ◽  
Vol 12 (1) ◽  
pp. 1885-1894 ◽  
Author(s):  
Gyeo-Re Han ◽  
Hangil Ki ◽  
Min-Gon Kim
Author(s):  
Antonia Perju ◽  
Nongnoot Wongkaew

AbstractLateral flow assays (LFAs) are the best-performing and best-known point-of-care tests worldwide. Over the last decade, they have experienced an increasing interest by researchers towards improving their analytical performance while maintaining their robust assay platform. Commercially, visual and optical detection strategies dominate, but it is especially the research on integrating electrochemical (EC) approaches that may have a chance to significantly improve an LFA’s performance that is needed in order to detect analytes reliably at lower concentrations than currently possible. In fact, EC-LFAs offer advantages in terms of quantitative determination, low-cost, high sensitivity, and even simple, label-free strategies. Here, the various configurations of EC-LFAs published are summarized and critically evaluated. In short, most of them rely on applying conventional transducers, e.g., screen-printed electrode, to ensure reliability of the assay, and additional advances are afforded by the beneficial features of nanomaterials. It is predicted that these will be further implemented in EC-LFAs as high-performance transducers. Considering the low cost of point-of-care devices, it becomes even more important to also identify strategies that efficiently integrate nanomaterials into EC-LFAs in a high-throughput manner while maintaining their favorable analytical performance.


2018 ◽  
Vol 90 (15) ◽  
pp. 9132-9137 ◽  
Author(s):  
Jinqi Deng ◽  
Mingzhu Yang ◽  
Jing Wu ◽  
Wei Zhang ◽  
Xingyu Jiang

2018 ◽  
Vol 28 (26) ◽  
pp. 1707161 ◽  
Author(s):  
Mohamed Shehata Draz ◽  
Maryam Moazeni ◽  
Manasa Venkataramani ◽  
Harini Lakshminarayanan ◽  
Ecem Saygili ◽  
...  

2019 ◽  
Vol 474 ◽  
pp. 112646 ◽  
Author(s):  
Roy Spijkerman ◽  
Lillian Hesselink ◽  
Pien Hellebrekers ◽  
Nienke Vrisekoop ◽  
Falco Hietbrink ◽  
...  

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