Selective Accumulation of Galactomannan Amphiphilic Nanomaterials in Pediatric Solid Tumor Xenografts Correlates with GLUT1 Gene Expression

2019 ◽  
Vol 11 (42) ◽  
pp. 38483-38496 ◽  
Author(s):  
Anna Zaritski ◽  
Helena Castillo-Ecija ◽  
Murali Kumarasamy ◽  
Ella Peled ◽  
Roni Sverdlov Arzi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Solid Tumor ◽  
Tumor Xenografts ◽  
Pediatric Solid Tumor ◽  
Selective Accumulation ◽  
Glut1 Gene

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

2004 ◽  
Vol 113 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Rochelle Bagatell ◽  
Jason Beliakoff ◽  
Cynthia L. David ◽  
Marilyn T. Marron ◽  
Luke Whitesell
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Solid Tumor ◽  
Hsp90 Inhibitors ◽  
Pediatric Solid Tumor ◽  
Apoptotic Proteins

Enhanced antitumor activity of irofulven in combination with irinotecan in pediatric solid tumor xenograft models

2004 ◽  
Vol 55 (5) ◽  
pp. 411-419 ◽  
Author(s):  
Michael H. Woo ◽  
Jennifer K. Peterson ◽  
Catherine Billups ◽  
Hua Liang ◽  
Mary-Ann Bjornsti ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Tumor ◽  
Tumor Xenograft ◽  
Pediatric Solid Tumor ◽  
Xenograft Models

scholarly journals Comparison of the Effects of Glibenclamide on Metabolic Parameters, GLUT1 Expression, and Liver Injury in Rats With Severe and Mild Streptozotocin-Induced Diabetes Mellitus

Medicina ◽  
2012 ◽  
Vol 48 (10) ◽  
pp. 78 ◽  
Author(s):  
Jelizaveta Sokolovska ◽  
Sergejs Isajevs ◽  
Olga Sugoka ◽  
Jelena Sharipova ◽  
Natalia Paramonova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Protein Expression ◽  
Diabetic Rats ◽  
Metabolic Parameters ◽  
Gene And Protein Expression ◽  
Glut1 Expression ◽  
Mild Diabetes ◽  
Streptozotocin Induced Diabetes ◽  
Glut1 Gene

Background and Objective. Glucose transport via GLUT1 protein could be one of additional mechanisms of the antidiabetic action of sulfonylureas. Here, the GLUT1 gene and the protein expression was studied in rats in the course of severe and mild streptozotocin-induced diabetes mellitus and under glibenclamide treatment. Material and Methods. Severe and mild diabetes mellitus was induced using different streptozotocin doses and standard or high fat chow. Rats were treated with glibenclamide (2 mg/kg daily, per os for 6 weeks). The therapeutic effect of glibenclamide was monitored by measuring several metabolic parameters. The GLUT1 mRNA and the protein expression in the kidneys, heart, and liver was studied by means of real-time R T-PCR and immunohistochemistry. Results. The glibenclamide treatment decreased the blood glucose concentration and increased the insulin level in both models of severe and mild diabetes mellitus. Severe diabetes mellitus provoked an increase in both GLUT1 gene and protein expression in the kidneys and the heart, which was nearly normalized by glibenclamide. In the kidneys of mildly diabetic rats, an increase in the GLUT1 gene expression was neither confirmed on the protein level nor influenced by the glibenclamide treatment. In the liver of severely diabetic rats, the heart and the liver of mildly diabetic rats, the GLUT1 gene and the protein expression was changed independently of each other, which might be explained by abortive transcription, and pre- and posttranslational modifications of gene expression. Conclusions. The GLUT1 expression was found to be affected by the glucose and insulin levels and can be modulated by glibenclamide in severely and mildly diabetic rats. Glibenclamide can prevent the liver damage caused by severe hyperglycemia.

scholarly journals The Efficacy and Safety of Apatinib in Refractory/Relapse Advanced Pediatric Solid Tumor: A Retrospective Study

2020 ◽  
Vol Volume 12 ◽  
pp. 6177-6185 ◽  
Author(s):  
Feifei Sun ◽  
Suying Lu ◽  
Zijun Zhen ◽  
Jia Zhu ◽  
Juan Wang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Solid Tumor ◽  
Efficacy And Safety ◽  
Pediatric Solid Tumor

Postoperative Fevers in Pediatric Solid Tumor Patients

2009 ◽  
Vol 31 (7) ◽  
pp. 485-488 ◽  
Author(s):  
Eleanor Hendershot ◽  
Ann Chang ◽  
Kimberly Colapinto ◽  
J. Ted Gerstle ◽  
David Malkin ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Tumor Patients ◽  
Pediatric Solid Tumor
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