scholarly journals Three-Dimensional Printed Scaffolds with Controlled Micro-/Nanoporous Surface Topography Direct Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells

2019 ◽  
Vol 11 (21) ◽  
pp. 18896-18906 ◽  
Author(s):  
Aruna Prasopthum ◽  
Mick Cooper ◽  
Kevin M. Shakesheff ◽  
Jing Yang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Surface Topography ◽  
Three Dimensional ◽  
Nanoporous Surface

scholarly journals Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells

Nanoscale ◽  
2013 ◽  
Vol 5 (10) ◽  
pp. 4171 ◽  
Author(s):  
Spencer W. Crowder ◽  
Dhiraj Prasai ◽  
Rutwik Rath ◽  
Daniel A. Balikov ◽  
Hojae Bae ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Graphene Foams

scholarly journals Growth on Metallo-Supramolecular Coordination Polyelectrolyte (MEPE) Stimulates Osteogenic Differentiation of Human Osteosarcoma Cells (MG63) and Human Bone Marrow Derived Mesenchymal Stem Cells

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1090 ◽  
Author(s):  
Janina Belka ◽  
Joachim Nickel ◽  
Dirk G. Kurth
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Differentiation ◽  
Osteogenic Differentiation ◽  
Three Dimensional ◽  
Cell Types ◽  
Growth Conditions ◽  
Cellular Environment ◽  
Human Osteosarcoma Cells ◽  
Supramolecular Coordination

Background: Culturing of cells is typically performed on standard tissue culture plates generating growth conditions, which in general do not reflect the native three-dimensional cellular environment. Recent investigations provide insights in parameters, which strongly affect the general cellular behavior triggering essential processes such as cell differentiation. The physical properties of the used material, such as stiffness, roughness, or topology, as well as the chemical composition of the cell-surface interface are shown to play a key role in the initiation of particular cellular responses. Methods: We extended our previous research, which identified thin films of metallo-supramolecular coordination polyelectrolytes (MEPEs) as substrate to trigger the differentiation of muscular precursor cells. Results: Here, we show that the same MEPEs similarly stimulate the osteogenic differentiation of pre-osteoblasts. Remarkably, MEPE modified surfaces also trigger the differentiation of primary bone derived mesenchymal stem cells (BMSCs) towards the osteogenic lineage. Conclusion: This result leads to the conclusion that these surfaces individually support the specification of cell differentiation toward lineages that correspond to the natural commitment of the particular cell types. We, therefore, propose that Fe-MEPEs may be used as scaffold for the treatment of defects at least in muscular or bone tissue.

Proliferation and osteogenic differentiation of mesenchymal stem cells on three-dimensional scaffolds made by thermal sintering method

2021 ◽  
Author(s):  
Farid Maleki ◽  
Hafez Jafari ◽  
Pejman Ghaffari-bohlouli ◽  
Mohsen Shahrousvand ◽  
Gity Mir Mohamad Sadeghi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Three Dimensional ◽  
Thermal Sintering ◽  
Sintering Method
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