Light-Cross-linked Enediyne Small-Molecule Micelle-Based Drug-Delivery System

2019 ◽  
Vol 11 (9) ◽  
pp. 8896-8903 ◽  
Author(s):  
Baojun Li ◽  
Yuequn Wu ◽  
Yue Wang ◽  
Mengsi Zhang ◽  
Huimin Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Molecule

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

2018 ◽  
Vol 54 (87) ◽  
pp. 12353-12356 ◽  
Author(s):  
Hardev Singh ◽  
Seo Jin Kim ◽  
Dong Hoon Kang ◽  
Hye-Ri Kim ◽  
Amit Sharma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Small Molecule ◽  
Glycyrrhetinic Acid ◽  
Active Targeting ◽  
Cell Type ◽  
Anticancer Drug Delivery

Herein, we explore glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) using a small molecule approach.

Cross-Linked Small-Molecule Micelle-Based Drug Delivery System: Concept, Synthesis, and Biological Evaluation

2016 ◽  
Vol 28 (21) ◽  
pp. 7757-7764 ◽  
Author(s):  
Chunyan Liao ◽  
Yun Chen ◽  
Yongchao Yao ◽  
Shiyong Zhang ◽  
Zhongwei Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Molecule ◽  
Biological Evaluation ◽  
System Concept ◽  
Synthesis And Biological Evaluation

scholarly journals Development and Testing of a Novel Universal Transdermal Drug Delivery Platform to Reduce Medication Nonadherence

2021 ◽  
Author(s):  
Gautam Ramesh ◽  
Ali Zamat ◽  
Srujan Vadlamudi ◽  
Neiman Liu ◽  
Praveen Akuthota
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Molecule ◽  
Transdermal Drug Delivery ◽  
Proof Of Concept ◽  
Medication Nonadherence ◽  
Transdermal Drug Delivery System ◽  
Long Course

Abstract Medication nonadherence results in avoidable symptom exacerbations and hospitalization, causing thousands of deaths and billions of dollars in healthcare costs annually. Although pharmacological therapies are present for chronic diseases, lengthy and complicated medication regimens often have high rates of nonadherence. Transdermal drug delivery is a potential method of reducing medication nonadherence as it allows for long-course medication regimens to be simplified to a one-time epidermal patch. We have engineered a transdermal drug delivery system on a customizable platform to longitudinally deliver a wide variety of soluble small-molecule drugs. As a proof of concept, we have chosen to administer long-course corticosteroids for chronic inflammatory disease via epidermal patch. The transdermal drug delivery system has an integrated tapering mechanism to avoid end-of-course steroid dependence and can incorporate other small-molecule medications required for cases of polypharmacy. To date, there have been no successful attempts to develop long-term steroid patches for systemic delivery which can be attributed to issues with patch adhesion and skin irritation over extended periods of time. We have analyzed such challenges and have designed a proof of concept system to overcome these obstacles in order to provide patients with a simple, inexpensive, and effective solution to complicated and long-term treatment regimens.

Real-time self-tracking of an anticancer small molecule nanodrug based on colorful fluorescence variations

RSC Advances ◽  
2016 ◽  
Vol 6 (15) ◽  
pp. 12472-12478 ◽  
Author(s):  
Siteng Wang ◽  
Hongping Deng ◽  
Ping Huang ◽  
Pei Sun ◽  
Xiaohua Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Small Molecule

A self-tracking drug delivery system was constructed using two anticancer drugs, resulting in colorful fluorescence variations during drug delivery.

scholarly journals A cooperative polymeric platform for tumor-targeted drug delivery

2016 ◽  
Vol 7 (1) ◽  
pp. 728-736 ◽  
Author(s):  
Wantong Song ◽  
Zhaohui Tang ◽  
Dawei Zhang ◽  
Mingqiang Li ◽  
Jingkai Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Molecule ◽  
Targeted Drug Delivery ◽  
Vascular Disrupting Agents ◽  
Targeted Nanoparticles ◽  
Targeted Drug ◽  
Targeted Drug Delivery System ◽  
Vascular Disrupting

A tumor-targeted drug delivery system with small-molecule vascular disrupting agents inducing coagulation environment inside tumor and coagulation-targeted nanoparticles accumulating there.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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