scholarly journals Human Cancer Cell Membrane-Coated Biomimetic Nanoparticles Reduce Fibroblast-Mediated Invasion and Metastasis and Induce T-Cells

2019 ◽  
Vol 11 (8) ◽  
pp. 7850-7861 ◽  
Author(s):  
Jiefu Jin ◽  
Balaji Krishnamachary ◽  
James D. Barnett ◽  
Samit Chatterjee ◽  
Di Chang ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Invasion And Metastasis ◽  
Biomimetic Nanoparticles

scholarly journals Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e111758 ◽  
Author(s):  
Rosanna La Rocca ◽  
Rossana Tallerico ◽  
Almosawy Talib Hassan ◽  
Gobind Das ◽  
Lakshmikanth Tadepally ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mechanical Stress ◽  
Mhc Class I ◽  
Cancer Cell ◽  
Human Cancer ◽  
Class I ◽  
Human Cancer Cell

Human Cancer Cell Membrane-Cloaked Fe3O4 Nanocubes for Homologous Targeting Improvement

2021 ◽  
Author(s):  
Lichuang Zhang ◽  
Hao Xu ◽  
Ziyi Cheng ◽  
Yan Wei ◽  
Ruize Sun ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell

scholarly journals Biomimetic nanoparticles enabled by cascade cell membrane coating for direct cross-priming of T cells

2021 ◽  
Author(s):  
Fangjie Chen ◽  
Lu Wang ◽  
Jinyao Liu
Keyword(s):  
T Cells ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Tumor Regression ◽  
Membrane Function ◽  
Direct Cross ◽  
Biomimetic Nanoparticles ◽  
Membrane Coating ◽  
Antigen Presenting ◽  
The Impact

Abstract Despite the activation of T lymphocytes by antigen-presenting cells is responsible for eliciting antigen-specific immune responses, their crosstalking suffers from temporospatial limitations and endogenous influencing factors, which restrict the generation of a strong antitumor immunity. Here, we describe the manipulation of cross-priming of T cells using biomimetic nanoparticles (BNs) enabled by cascade cell membrane coating. BNs are resulted from coating nanoparticulate substrates with cell membranes extracted from dendritic cells (DCs) that are pre-pulsed with cancer cell membrane-coated nanoparticles. With a DC membrane that presents an array of cancer cell membrane antigen epitopes, BNs inherit intrinsic membrane function of DCs. Strikingly, BNs can directly cross-prime T cells and provoke robust yet antigen-specific antitumor responses in multiple mouse models. Combination with clinical anti-programmed death-1 antibodies demonstrates a practical way of BNs to achieve desirable tumor regression and survival rate. This work spotlights the impact of nanoparticles on direct cross-priming of T cells and supports a unique yet modulate platform for boosting an effective adaptive immunity for immunotherapy.

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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