Zwitterionic Gadolinium(III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis

2019 ◽  
Vol 11 (17) ◽  
pp. 15212-15221 ◽  
Author(s):  
Jinyuan Liu ◽  
Zhijuan Xiong ◽  
Jiulong Zhang ◽  
Chen Peng ◽  
Barbara Klajnert-Maculewicz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Lung Cancer ◽  
Gold Nanoparticles ◽  
Magnetic Resonance ◽  
Cancer Metastasis ◽  
Resonance Imaging ◽  
Lung Cancer Metastasis ◽  
Enhanced Computed Tomography

Preparation of Gd-Au Dendrimer-Entrapped Gold Nanoparticles-Folic Acid Nanoparticles and Its Application in Computed Tomography/Magnetic Resonance Imaging Dual-Modality Diagnosis of Abdominal Tumors

2021 ◽  
Vol 13 (7) ◽  
pp. 1364-1373
Author(s):  
Yumei Zhang ◽  
Ruina Pei ◽  
Tao Luo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Receptor Expression ◽  
Average Particle ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Abdominal Tumors

ABSTRACTThe development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2 oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution. When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression. During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body and further used for the early diagnosis of abdominal tumors.

Failure of contrast enhanced computed tomography scans to identify an orbital abscess. The benefit of magnetic resonance imaging

2007 ◽  
Vol 122 (6) ◽  
pp. 639-640 ◽  
Author(s):  
D Mcintosh ◽  
M Mahadevan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Acute Sinusitis ◽  
Illustrative Case ◽  
Resonance Imaging ◽  
Computed Tomography Scanning ◽  
Enhanced Computed Tomography ◽  
Orbital Complications

AbstractIntroduction:Acute sinusitis is a relatively common condition, which usually responds to medical therapy. In most cases, there are no sequelae or complications subsequent to this infection. However, like many acute illnesses, there are well documented complications of acute sinusitis, and in particular these include peri-orbital and intracranial spread.Objective:The purpose of this paper is to highlight the importance of vigilance in peri-orbital involvement and the limitations of imaging techniques, such as computed tomography scanning. An illustrative case is presented to demonstrate this.Conclusion:Magnetic resonance imaging scanning is a valuable modality in assessing complex presentations of peri-orbital complications of acute sinusitis.

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