scholarly journals Retraction of “Strontium-Substituted Nanohydroxyapatite Coatings To Decrease Aseptic Loosening of Femoral Prosthesis: Safety and Efficacy in a Rat Model”

2019 ◽  
Vol 11 (31) ◽  
pp. 28595-28595
Author(s):  
Genwen Mao ◽  
Chuang Wang ◽  
Qian Li ◽  
Tonghe Zhu ◽  
Jianhai Yang ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Rat Model ◽  
Femoral Prosthesis ◽  
Safety And Efficacy

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

scholarly journals Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis

2017 ◽  
Vol 6 (10) ◽  
pp. 1905-1916 ◽  
Author(s):  
Jhon Cores ◽  
M. Taylor Hensley ◽  
Kathryn Kinlaw ◽  
S. Michaela Rikard ◽  
Phuong-Uyen Dinh ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Rat Model ◽  
Safety And Efficacy

scholarly journals Prevention of adhesions post-abdominal surgery: Assessing the safety and efficacy of Chitogel with Deferiprone in a rat model

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244503
Author(s):  
Rajan Sundaresan Vediappan ◽  
Catherine Bennett ◽  
Clare Cooksley ◽  
John Finnie ◽  
Markus Trochsler ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Abdominal Surgery ◽  
Rat Model ◽  
Adhesion Formation ◽  
Pelvic Surgery ◽  
Albino Rats ◽  
Adhesion Barrier ◽  
Midline Laparotomy ◽  
Safety And Efficacy ◽  
To Receive

Introduction Adhesions are often considered to be an inevitable consequence of abdominal and pelvic surgery, jeopardizing the medium and long-term success of these procedures. Numerous strategies have been tested to reduce adhesion formation, however, to date, no surgical or medical therapeutic approaches have been successful in its prevention. This study demonstrates the safety and efficacy of Chitogel with Deferiprone and/or antibacterial Gallium Protoporphyrin in different concentrations in preventing adhesion formation after abdominal surgery. Materials and methods 112 adult (8–10 week old) male Wistar albino rats were subjected to midline laparotomy and caecal abrasion, with 48 rats having an additional enterotomy and suturing. Kaolin (0.005g/ml) was applied to further accelerate adhesion formation. The abrasion model rats were randomized to receive saline, Chitogel, or Chitogel plus Deferiprone (5, 10 or 20 mM), together with Gallium Protoporphyrin (250μg/mL). The abrasion with enterotomy rats were randomised to receive saline, Chitogel or Chitogel with Deferiprone (1 or 5 mM). At day 21, rats were euthanised, and adhesions graded macroscopically and microscopically; the tensile strength of the repaired caecum was determined by an investigator blinded to the treatment groups. Results Chitogel with Deferiprone 5 mM significantly reduced adhesion formation (p<0.01) when pathologically assessed in a rat abrasion model. Chitogel with Deferiprone 5 mM and 1 mM also significantly reduced adhesions (p<0.05) after abrasion with enterotomy. Def-Chitogel 1mM treatment did not weaken the enterotomy site with treated sites having significantly better tensile strength compared to control saline treated enterotomy rats. Conclusions Chitogel with Deferiprone 1 mM constitutes an effective preventative anti-adhesion barrier after abdominal surgery in a rat model. Moreover, this therapeutic combination of agents is safe and does not weaken the healing of the sutured enterotomy site.

Uncemented Custom-Made Femoral Components

2002 ◽  
Vol 12 (4) ◽  
pp. 365-370 ◽  
Author(s):  
B. Mohan ◽  
J.R. Nixon ◽  
E. Doran
Keyword(s):  
Titanium Alloy ◽  
Aseptic Loosening ◽  
Failure Rate ◽  
Hip Replacement ◽  
Average Duration ◽  
Femoral Prosthesis ◽  
Younger Patients ◽  
Custom Made ◽  
Fit And Fill

We present our experience of total hip replacement (THR) in younger patients using a custom-made smooth titanium alloy femoral prosthesis. Measurements made from pre-operative marker radiographs allowed creation of templates and subsequent computer analysis to mill the stem prior to surgery. Fifty-one such cementless implants were carried out in 43 patients between January 1993 and June 1996 with follow-up to an average of 47 months. Sixteen hips have required revision to date; 13 of these operations were for aseptic loosening. Two more were awaiting revision, giving an overall failure rate of 35.3 %. The average duration from primary operation to revision was 47 months. Thus, even though the concept of an uncemented custom-made femoral component is attractive, the failure rate was found to be unacceptably high. This device may achieve “fit and fill”, but adequate bone on- or in-growth was not achieved. On the basis of these data we have discontinued the use of this implant since 1996.

scholarly journals In vivo safety and efficacy testing of a thermally triggered injectable hydrogel scaffold for bone regeneration and augmentation in a rat model

Oncotarget ◽  
2018 ◽  
Vol 9 (26) ◽  
pp. 18277-18295 ◽  
Author(s):  
Abbey A. Thorpe ◽  
Christine Freeman ◽  
Paula Farthing ◽  
Jill Callaghan ◽  
Paul V. Hatton ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Rat Model ◽  
Hydrogel Scaffold ◽  
Injectable Hydrogel ◽  
Safety And Efficacy ◽  
Thermally Triggered

Revision of Aseptic Loosening of the Femora] Implant in a Dog Using Cable Cerclage

1999 ◽  
Vol 12 (02) ◽  
pp. 97-101 ◽  
Author(s):  
A. R. Cross ◽  
O. I. Lanz ◽  
L. Blaeser
Keyword(s):  
Case Report ◽  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Femoral Fracture ◽  
Femoral Prosthesis ◽  
Cobalt Chromium ◽  
German Shepherd ◽  
Total Hip ◽  
Cemented Total Hip Arthroplasty

SummaryAseptic loosening of the femoral implant (ALFI) has been reported in 7.2% of total hip arthroplasty procedures in the dog. In this case report, ALFI was diagnosed in a nine year old male German Shepherd, seven years after the initial cemented total hip arthroplasty was performed. The revision of the ALFI was performed using a longitudinal osteotomy to extract the polymethylmethacrylate and the titanium femoral prosthesis was replaced with a cobalt chromium model. The osteotomy and an iatrogenic femoral fracture were repaired using four 1.3 mm cables. Postoperative radiographs revealed satisfactory alignment, reduction of the osteotomy and adequate positioning of the femoral prosthesis.Case report describing the revision of aseptic loosening of the femoral implant seven years after the initial total hip arthroplasty was performed. The revision utilized four 1.3 mm cable cerclage.

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