PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release

2019 ◽  
Vol 11 (6) ◽  
pp. 5701-5713 ◽  
Author(s):  
Mengzhen Xu ◽  
Can Yang Zhang ◽  
Junguang Wu ◽  
Huige Zhou ◽  
Ru Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymers ◽  
Tumor Acidity ◽  
Self Assembled

Thermo-responsive self-assembled polymeric micelles for drug delivery in vitro

2000 ◽  
Vol 205 (1-2) ◽  
pp. 165-172 ◽  
Author(s):  
In-Sook Kim ◽  
Young-Il Jeong ◽  
Chong-Su Cho ◽  
Sung-Ho Kim
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Self Assembled

Rapidly cell-penetrating and reductive milieu-responsive nanoaggregates assembled from an amphiphilic folate-camptothecin prodrug for enhanced drug delivery and controlled release

2017 ◽  
Vol 5 (3) ◽  
pp. 444-454 ◽  
Author(s):  
Zhigang Xu ◽  
Meili Hou ◽  
Xiaoxiao Shi ◽  
Yong-E. Gao ◽  
Peng Xue ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Folate Receptors ◽  
Tumour Detection ◽  
Cell Penetrating ◽  
Self Assembled

Self-assembled small molecular prodrug loaded with camptothecin in response to glutathione and folate receptors for combined tumour detection and treatment.

Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55139-55149 ◽  
Author(s):  
Jinlong Yang ◽  
Chunmei Gao ◽  
Shaoyu Lü ◽  
Xinggang Wang ◽  
Mingjia Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Deoxycholic Acid ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Ph Response ◽  
Self Assembled

Self-assembled micelles of novel graft amphiphilic copolymers for drug controlled release

2011 ◽  
Vol 85 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Wei Xun ◽  
Hui-Yuan Wang ◽  
Ze-Yong Li ◽  
Si-Xue Cheng ◽  
Xian-Zheng Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Amphiphilic Copolymers ◽  
Drug Controlled Release ◽  
Self Assembled

Macromolecular engineering and stimulus response in the design of advanced drug delivery systems

MRS Bulletin ◽  
2010 ◽  
Vol 35 (9) ◽  
pp. 665-672 ◽  
Author(s):  
Christine Jérôme
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Colloidal Particles ◽  
Polymeric Micelles ◽  
Complex Structure ◽  
Delivery Systems ◽  
Target Cells ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Research Activity

Extensive research activity is currently devoted to controlled drug delivery systems, mainly as nano-sized particles. Although biocompatible and (bio)degradable polymers play a key role in this field, their shaping into colloidal particles (e.g., polymeric micelles and nanoparticles) usually requires the proper design of amphiphilic copolymers as effective stabilizers. Strategies for synthesizing these copolymers that preserve the intrinsic properties of the constitutive polymers are discussed in this article. Synthesis of amphiphilic copolymers with a more complex structure and endowed with functionality is also considered, with the purpose of enhancing the performance of the nanocarriers. The focus is increasingly on nanocarriers of the third generation, which resist coalescence and elimination by the immune system, and which are readily incorporated into chosen target cells. The more recent quest is for smart nanocarriers that exhibit the additional capacity of being stimuli-responsive.

Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery

Polymer ◽  
2014 ◽  
Vol 55 (13) ◽  
pp. 2977-2985 ◽  
Author(s):  
Fangxia Zhu ◽  
Qinglai Yang ◽  
Yuan Zhuang ◽  
Yuanqing Zhang ◽  
Zhifeng Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Self Assembled

Fabrication of Mixed Polymeric Micelles Based on Stimuli-Responsive Amphiphilic Copolymers for Drug Delivery and Controlled Release

NANO ◽  
2020 ◽  
Vol 15 (03) ◽  
pp. 2050040 ◽  
Author(s):  
Jia Liu ◽  
Juan Li ◽  
Tingting Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Block Copolymers ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Mixed Polymeric Micelles ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

In this report, mixed polymeric micelles (MPMs) system self-assembled from two kinds of cholesterol-grafted amphiphilic block copolymers cholesterol modified poly ([Formula: see text]-amino esters)-grafted disulfide poly (ethylene glycol) methyl ether (PAE(-ss-mPEG)-[Formula: see text]-Chol) and poly([Formula: see text]-amino ester)-g-poly(ethylene glycol) methyl ether-cholesterol (PAE-[Formula: see text]-mPEG-Chol) were prepared for drug delivery and controlled release with pH and redox-responsibilities. The self-assembly of two block copolymers was evaluated by measurement of critical micelle concentration (CMC) values using fluorescence spectroscopy. The hydrodynamic diameter, polydispersity index (PDI) and zeta-potential of MPMs in aqueous were recorded by dynamic light scattering (DLS) at different conditions. Doxorubicin (DOX) was efficiently encapsulated in the micellar core by the hydrophobic interaction. The drug loading content (LC) and encapsulation efficacy (EE) of MPMs with different formulations were evaluated. The DOX was released due to the swelling and disassembly of MPMs induced by low pH and high glutathione (GSH) concentrations. The in vitro results demonstrated that drug release rate and cumulative release were obviously dependent on pH values and reducing agents. The results showed that the MPMs could be the potential anticancer drug delivery carriers with pH/redox-triggered drug release profile.

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