Blocking Autophagic Flux Enhances Iron Oxide Nanoparticle Photothermal Therapeutic Efficiency in Cancer Treatment

2018 ◽  
Vol 10 (33) ◽  
pp. 27701-27711 ◽  
Author(s):  
Xiaoqing Ren ◽  
Yiting Chen ◽  
Haibao Peng ◽  
Xiaoling Fang ◽  
Xiulei Zhang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticle ◽  
Autophagic Flux ◽  
Therapeutic Efficiency ◽  
Oxide Nanoparticle

scholarly journals Iron oxide nanoparticle hyperthermia and radiation cancer treatment

2009 ◽  
Author(s):  
S. M. Cassim ◽  
A. J. Giustini ◽  
A. A. Petryk ◽  
R. A. Strawbridge ◽  
P. J. Hoopes
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals Iron oxide nanoparticle hyperthermia and chemotherapy cancer treatment

2009 ◽  
Author(s):  
A. A. Petryk ◽  
A. J. Giustini ◽  
P. Ryan ◽  
R. R. Strawbridge ◽  
P. J. Hoopes
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3013
Author(s):  
Julian Palzer ◽  
Lea Eckstein ◽  
Ioana Slabu ◽  
Oliver Reisen ◽  
Ulf P. Neumann ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Photothermal Therapy ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Gastrointestinal Malignancies ◽  
Magnetic Fluid Hyperthermia ◽  
Oxide Nanoparticle

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

Similarities and differences in ablative and non-ablative iron oxide nanoparticle hyperthermia cancer treatment

2015 ◽  
Author(s):  
Alicia A. Petryk ◽  
Adwiteeya Misra ◽  
Elliot J. Kastner ◽  
Courtney M. Mazur ◽  
James D. Petryk ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Similarities And Differences

scholarly journals Intratumoral iron oxide nanoparticle hyperthermia and radiation cancer treatment

2007 ◽  
Author(s):  
P. J. Hoopes ◽  
R. R. Strawbridge ◽  
U. J. Gibson ◽  
Q. Zeng ◽  
Z. E. Pierce ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 1015 ◽  
Author(s):  
Mariia Uzhytchak ◽  
Barbora Smolková ◽  
Mariia Lunova ◽  
Milan Jirsa ◽  
Adam Frtús ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cellular Localization ◽  
P53 Protein ◽  
Iron Oxide Nanoparticle ◽  
Autophagic Flux ◽  
Hepatic Cells ◽  
Oxide Nanoparticle ◽  
Underlying Mechanisms ◽  
The Impact ◽  
Hepatic Cell Lines

Iron oxide-based nanoparticles have been repeatedly shown to affect lysosomal-mediated signaling. Recently, nanoparticles have demonstrated an ability to modulate autophagic flux via lysosome-dependent signaling. However, the precise underlying mechanisms of such modulation as well as the impact of cellular genetic background remain enigmatic. In this study, we investigated how lysosomal-mediated signaling is affected by iron oxide nanoparticle uptake in three distinct hepatic cell lines. We found that nanoparticle-induced lysosomal dysfunction alters sub-cellular localization of pmTOR and p53 proteins. Our data indicate that alterations in the sub-cellular localization of p53 protein induced by nanoparticle greatly affect the autophagic flux. We found that cells with high levels of Bcl-2 are insensitive to autophagy initiated by nanoparticles. Altogether, our data identify lysosomes as a central hub that control nanoparticle-mediated responses in hepatic cells. Our results provide an important fundamental background for the future development of targeted nanoparticle-based therapies.

scholarly journals Reversible magnetism switching of iron oxide nanoparticle dispersions by controlled agglomeration

2021 ◽  
Author(s):  
Stephan Müssig ◽  
Björn Kuttich ◽  
Florian Fidler ◽  
Daniel Haddad ◽  
Susanne Wintzheimer ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Light Scattering ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Nanoparticle Dispersions ◽  
Oxide Nanoparticle

The controlled agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs) was used to rapidly switch their magnetic properties. Small-angle X-ray scattering (SAXS) and dynamic light scattering showed that tailored iron oxide...

Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas

2021 ◽  
Vol 13 (7) ◽  
pp. 7924-7944
Author(s):  
Yadileiny Portilla ◽  
Sara Mellid ◽  
Alberto Paradela ◽  
Antonio Ramos-Fernández ◽  
Neus Daviu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Nanoparticle Coatings

Succinylated heparin monolayer coating vastly increases superparamagnetic iron oxide nanoparticle T2 proton relaxivity

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12905-12914 ◽  
Author(s):  
Manman Xie ◽  
Shijia Liu ◽  
Christopher J. Butch ◽  
Shaowei Liu ◽  
Ziyang Wang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Clinical Use ◽  
History Of ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

Superparamagnetic iron oxide nanoparticles (SPIONs) have a history of clinical use as contrast agents in T2 weighted MRI, though relatively low T2 relaxivity has caused them to fall out of favor as new faster MRI techniques have gained prominence.

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