Polyamino Acid Layer-by-Layer (LbL) Constructed Silica-Supported Mesoporous Titania Nanocarriers for Stimuli-Responsive Delivery of microRNA 708 and Paclitaxel for Combined Chemotherapy

2018 ◽  
Vol 10 (29) ◽  
pp. 24392-24405 ◽  
Author(s):  
Biki Gupta ◽  
Hima Bindu Ruttala ◽  
Bijay Kumar Poudel ◽  
Shiva Pathak ◽  
Shobha Regmi ◽  
...  
2017 ◽  
Vol 95 ◽  
pp. 195-206 ◽  
Author(s):  
A. Osypova ◽  
C.-A. Fustin ◽  
C.-M. Pradier ◽  
J. Landoulsi ◽  
S. Demoustier-Champagne

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1208
Author(s):  
Narsimha Mamidi ◽  
Ramiro Velasco Delgadillo ◽  
Aldo Gonzáles Ortiz ◽  
Enrique Barrera

Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular π-π stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 ± 8.2 MPa of the tensile strength (σult), 43.2 ± 1.1 GPa of Young’s modulus (E), and 164.5 ± 1.7 Jg−1 of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.


2017 ◽  
Vol 9 (17) ◽  
pp. 14858-14867 ◽  
Author(s):  
Rupam Sarma ◽  
Md. Saiful Islam ◽  
Anne-Frances Miller ◽  
Dibakar Bhattacharyya

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Porta-i-Batalla ◽  
Chris Eckstein ◽  
Elisabet Xifré-Pérez ◽  
Pilar Formentín ◽  
J. Ferré-Borrull ◽  
...  

2008 ◽  
Vol 324 (1-2) ◽  
pp. 47-54 ◽  
Author(s):  
John E. Wong ◽  
Akhilesh K. Gaharwar ◽  
Detlef Müller-Schulte ◽  
Dhirendra Bahadur ◽  
Walter Richtering

Small ◽  
2011 ◽  
Vol 7 (18) ◽  
pp. 2640-2649 ◽  
Author(s):  
Rui R. Costa ◽  
Catarina A. Custódio ◽  
Francisco J. Arias ◽  
José C. Rodríguez-Cabello ◽  
João F. Mano

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