A New Photosensitized Oxidation-Responsive Nanoplatform for Controlled Drug Release and Photodynamic Cancer Therapy

2018 ◽  
Vol 10 (25) ◽  
pp. 21160-21172 ◽  
Author(s):  
Huan-Pu Yeh ◽  
Andrea C. del Valle ◽  
Ming-Chen Syu ◽  
Yu Qian ◽  
Yu-Cheng Chang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Photosensitized Oxidation ◽  
Photodynamic Cancer Therapy

scholarly journals Ultrasound‐controlled drug release and drug activation for cancer therapy

Exploration ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 20210023
Author(s):  
Li Tu ◽  
Zhihuan Liao ◽  
Zheng Luo ◽  
Yun‐Long Wu ◽  
Andreas Herrmann ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Drug Activation

scholarly journals Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 5499-5509 ◽  
Author(s):  
Yunqian Li ◽  
Meng Xu ◽  
Udesh Dhawan ◽  
Wai-Ching Liu ◽  
Kou-Ting Wu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Gold Alloy ◽  
Controlled Drug Release ◽  
Alloy Nanoparticles

Multi-Activated Polymeric Micelles with Charge-Conversion and ROS-Controlled Drug Release for Efficient Cancer Therapy

2017 ◽  
Vol 13 (8) ◽  
pp. 946-959 ◽  
Author(s):  
Changzhen Sun ◽  
Yan Liang ◽  
Mingying Zhao ◽  
Na Hao ◽  
Long Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Polymeric Micelles ◽  
Controlled Drug Release

scholarly journals Magnetoliposomes Based on Shape Anisotropic Calcium/Magnesium Ferrite Nanoparticles as Nanocarriers for Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1248
Author(s):  
Beatriz D. Cardoso ◽  
Ana Rita O. Rodrigues ◽  
Manuel Bañobre-López ◽  
Bernardo G. Almeida ◽  
Carlos O. Amorim ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Ferrite Nanoparticles ◽  
Individual Characteristics ◽  
Release Kinetic ◽  
Magnesium Ferrite ◽  
Promising Therapeutic Approach ◽  
The Individual

Multifunctional lipid nanocarriers are a promising therapeutic approach for controlled drug release in cancer therapy. Combining the widely used liposome structure with magnetic nanoparticles in magnetoliposomes allies, the advantages of using liposomes include the possibility to magnetically guide, selectively accumulate, and magnetically control the release of drugs on target. The effectiveness of these nanosystems is intrinsically related to the individual characteristics of the two main components—lipid formulation and magnetic nanoparticles—and their physicochemical combination. Herein, shape-anisotropic calcium-substituted magnesium ferrite nanoparticles (Ca0.25Mg0.75Fe2O4) were prepared for the first time, improving the magnetic properties of spherical counterparts. The nanoparticles revealed a superparamagnetic behavior, high saturation magnetization (50.07 emu/g at 300 K), and a large heating capacity. Furthermore, a new method for the synthesis of solid magnetoliposomes (SMLs) was developed to enhance their magnetic response. The manufacturing technicalities were optimized with different lipid compositions (DPPC, DPPC/Ch, and DPPC/DSPE-PEG) originating nanosystems with optimal sizes for biomedical applications (around or below 150 nm) and low polydispersity index. The high encapsulation efficiency of doxorubicin in these magnetoliposomes was proven, as well as the ability of the drug-loaded nanosystems to interact with cell membrane models and release DOX by fusion. SMLs revealed to reduce doxorubicin interaction with human serum albumin, contributing to a prolonged bioavailability of the drug upon systemic administration. Finally, the drug release kinetic assays revealed a preferable DOX release at hyperthermia temperatures (42 °C) and acidic conditions (pH = 5.5), indicating them as promising controlled release nanocarriers by either internal (pH) and external (alternate magnetic field) stimuli in cancer therapy.

scholarly journals Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1098 ◽  
Author(s):  
Ray Chang ◽  
Wei-Bor Tsai
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Green Laser ◽  
Cancer Drug ◽  
Cell Mortality ◽  
Anti Cancer ◽  
Temperature Stimulus ◽  
Sodium Copper Chlorophyllin ◽  
532 Nm

Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment.

Fe3O4@carbon@zeolitic imidazolate framework-8 nanoparticles as multifunctional pH-responsive drug delivery vehicles for tumor therapy in vivo

2015 ◽  
Vol 3 (46) ◽  
pp. 9033-9042 ◽  
Author(s):  
Mengni He ◽  
Jiajia Zhou ◽  
Jian Chen ◽  
Fangcai Zheng ◽  
Dongdong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Therapy ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Zeolitic Imidazolate Framework ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy.

Theranostic nanoparticles enabling the release of phosphorylated gemcitabine for advanced pancreatic cancer therapy

2020 ◽  
Vol 8 (12) ◽  
pp. 2410-2417
Author(s):  
Qingbing Wang ◽  
Xingjun Zhu ◽  
Zhiyuan Wu ◽  
Tao Sun ◽  
Wei Huang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Release ◽  
Advanced Pancreatic Cancer ◽  
Controlled Drug Release ◽  
Theranostic Nanoparticles ◽  
Pancreatic Cancer Therapy

A lanthanide-based visualizable photothermal controlled drug release nanosystem was developed to overcome the drug resistance of gemcitabine for pancreatic cancer.

scholarly journals Inside Front Cover: Ultrasound‐controlled drug release and drug activation for cancer therapy (EXP2 3/2021)

Exploration ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 20210329
Author(s):  
Li Tu ◽  
Zhihuan Liao ◽  
Zheng Luo ◽  
Yun‐Long Wu ◽  
Andreas Herrmann ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Front Cover ◽  
Drug Activation

Near-infrared light-controlled drug release and cancer therapy with polymer-caged upconversion nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5269-5276 ◽  
Author(s):  
Qingjian Xing ◽  
Najun Li ◽  
Yang Jiao ◽  
Dongyun Chen ◽  
Jiaying Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Self Assembly ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Assembly Process ◽  
The Core ◽  
Triggered Drug Release

The core–shell nanocarrier, based on spiropyran-containing copolymer coated upconversion nanocomposites, was successfully prepared via a facile self-assembly process for NIR-triggered drug release and cancer therapy.

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