Water-Dispersible Prussian Blue Hyaluronic Acid Nanocubes with Near-Infrared Photoinduced Singlet Oxygen Production and Photothermal Activities for Cancer Theranostics

2018 ◽  
Vol 10 (21) ◽  
pp. 18036-18049 ◽  
Author(s):  
Bo Zhou ◽  
Bang-Ping Jiang ◽  
Wanying Sun ◽  
Fang-Mian Wei ◽  
Yun He ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Singlet Oxygen ◽  
Prussian Blue ◽  
Near Infrared ◽  
Oxygen Production ◽  
Water Dispersible ◽  
Cancer Theranostics

scholarly journals Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics

Theranostics ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 466-481 ◽  
Author(s):  
Yongbo Yang ◽  
Lijia Jing ◽  
Xiaoda Li ◽  
Li Lin ◽  
Xiuli Yue ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Quantum Dot ◽  
Prussian Blue ◽  
Cancer Theranostics

Near-Infrared Responsive Doxorubicin Loaded Hollow Mesoporous Prussian Blue Nanoparticles Combined with Dissolvable Hyaluronic Acid Microneedle System for Human Oral Squamous Cell Carcinoma Therapy

2020 ◽  
Vol 16 (5) ◽  
pp. 721-738
Author(s):  
Yuntao Xu ◽  
Ying Hao ◽  
Wei Li ◽  
Yao Xiao ◽  
Tianlin Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Hyaluronic Acid ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prussian Blue ◽  
Squamous Cell ◽  
Near Infrared ◽  
Transdermal Drug Delivery System ◽  
Prussian Blue Nanoparticles ◽  
Nir Laser

Oral squamous cell carcinoma (OSCC) is one of the most common cancers in developing countries particularly in those aged over 50. Traditional treatment is with surgery, radiotherapy, chemotherapy, or a combination of these which often results in considerable discomfort to the patient. Here we describe a potential alternative which employs a near-infrared (NIR) responsive dissolvable microneedle system (HMPBs&DOX@HA MNs) made of hyaluronic acid (HA) with hollow mesoporous Prussian blue nanoparticles (HMPBs) loaded with doxorubicin (DOX). HMPBs&DOX@HA MNs can easily penetrate the skin, and shows the ability to heat and maintain the internal temperature of tumor tissue at more than 60 C under the irradiation of an NIR laser. Besides, the DOX release behavior can also be regulated by the NIR laser. HMPBs&DOX@HA MNs reveals not only strong cell inhibition in vitro, but also prominent antitumor efficacy in vivo with all tumor-bearing mice cured in just one treatment and with no recurrence. This innovative transdermal drug delivery system minimizes the side effects while eliminating tumors. It has great potential to be an effective clinical treatment of OSCC.

scholarly journals Designing a highly stable coordination-driven metallacycle for imaging-guided photodynamic cancer theranostics

2020 ◽  
Vol 11 (30) ◽  
pp. 7940-7949
Author(s):  
Lizhen He ◽  
Li-Xuan Cai ◽  
Meng-Hua Li ◽  
Guang-Lu Zhang ◽  
Li-Peng Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Chemical Stability ◽  
Self Assembly ◽  
Assembly Process ◽  
Oxygen Production ◽  
Photodynamic Cancer Therapy ◽  
Application Potential ◽  
Cancer Theranostics

A highly-luminescent metallacycle with chemical stability and singlet oxygen production ability were obtained by a spontaneous deprotonation self-assembly process, which exhibits application potential in imaging-guided photodynamic cancer therapy.

Time-Resolved Near Infrared Studies on Singlet Oxygen Production by the Photosensitizing 2-Arylpropionic Acids

1997 ◽  
Vol 65 (5) ◽  
pp. 828-832 ◽  
Author(s):  
Daniel Peña ◽  
Cristina Martí ◽  
Santi Noneil ◽  
Luis A. Martínez ◽  
Miguel A. Miranda
Keyword(s):  
Singlet Oxygen ◽  
Near Infrared ◽  
Oxygen Production ◽  
Time Resolved ◽  
Infrared Studies

scholarly journals Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6618
Author(s):  
Ruth Prieto-Montero ◽  
Alejandro Prieto-Castañeda ◽  
Alberto Katsumiti ◽  
Miren P. Cajaraville ◽  
Antonia R. Agarrabeitia ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Absorption Capacity ◽  
Oxygen Production ◽  
Photodynamic Therapy Of Cancer ◽  
Custom Made ◽  
Fluorescence Efficiency ◽  
Covalently Linked

BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro.

scholarly journals New Approach in the Application of Conjugated Polymers: The Light-Activated Source of Versatile Singlet Oxygen Molecule

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1098
Author(s):  
Agata Blacha-Grzechnik
Keyword(s):  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Short Review ◽  
The Novel ◽  
New Approach ◽  
Intermolecular Energy ◽  
Intermolecular Energy Transfer ◽  
High Absorption

For many years, the research on conjugated polymers (CPs) has been mainly focused on their application in organic electronics. Recent works, however, show that due to the unique optical and photophysical properties of CPs, such as high absorption in UV–Vis or even near-infrared (NIR) region and efficient intra-/intermolecular energy transfer, which can be relatively easily optimized, CPs can be considered as an effective light-activated source of versatile and highly reactive singlet oxygen for medical or catalytic use. The aim of this short review is to present the novel possibilities that lie dormant in those exceptional polymers with the extended system of π-conjugated bonds.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

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