PEGylated Self-Assembled Nano-Bacitracin A: Probing the Antibacterial Mechanism and Real-Time Tracing of Target Delivery in Vivo

2018 ◽  
Vol 10 (13) ◽  
pp. 10688-10705 ◽  
Author(s):  
Wei Hong ◽  
Yining Zhao ◽  
Yuru Guo ◽  
Chengcheng Huang ◽  
Peng Qiu ◽  
...  
Keyword(s):  
Real Time ◽  
Antibacterial Mechanism ◽  
Target Delivery ◽  
Self Assembled ◽  
Bacitracin A

scholarly journals Synthesis, Construction, and Evaluation of Self-Assembled Nano-Bacitracin a as an Efficient Antibacterial Agent in vitro and in vivo [Corrigendum]

2020 ◽  
Vol Volume 15 ◽  
pp. 4753-4754
Author(s):  
Wei Hong ◽  
Xiang Gao ◽  
Peng Qiu ◽  
Jie Yang ◽  
Mingxi Qiao ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Self Assembled ◽  
Bacitracin A

CNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoring

2011 ◽  
Vol 7 (3) ◽  
pp. 351-359 ◽  
Author(s):  
Yu-Xiang Liang ◽  
Sunny W.H. Cheung ◽  
Kevin C.W. Chan ◽  
Ed X. Wu ◽  
David K.C. Tay ◽  
...  
Keyword(s):  
Real Time ◽  
Chronic Injury ◽  
Cns Regeneration ◽  
In Vivo Monitoring ◽  
Self Assembled

Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy

2020 ◽  
Vol 56 (25) ◽  
pp. 3629-3632 ◽  
Author(s):  
Xinwei Tian ◽  
Zhao Li ◽  
Ning Ding ◽  
Jiahang Zhang
Keyword(s):  
Cancer Therapy ◽  
Real Time ◽  
Cancer Chemotherapy ◽  
Near Infrared ◽  
Self Assembled

A novel near-infrared ratiometric fluorescent theranostic nanoprobe is applied for real-time fluorescence tracking and imaging cancer therapy in vivo and in situ.

scholarly journals Synthesis, construction, and evaluation of self-assembled nano-bacitracin A as an efficient antibacterial agent in vitro and in vivo

2017 ◽  
Vol Volume 12 ◽  
pp. 4691-4708 ◽  
Author(s):  
Wei Hong ◽  
Xiang Gao ◽  
Peng Qiu ◽  
Jie Yang ◽  
Mingxi Qiao ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Self Assembled ◽  
Bacitracin A

scholarly journals Synthesis, construction, and evaluation of self-assembled nano-bacitracin A as an efficient antibacterial agent in vitro and in vivo [Corrigendum]

2019 ◽  
Vol Volume 14 ◽  
pp. 771-772
Author(s):  
Wei Hong ◽  
Xiang Gao ◽  
Peng Qiu ◽  
Jie Yang ◽  
Mingxi Qiao ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Self Assembled ◽  
Bacitracin A

Voltammetric Detection of Tetrodotoxin Real-Time In Vivo of Mouse Organs using DNA-Immobilized Carbon Nanotube Sensors

2019 ◽  
Vol 15 (5) ◽  
pp. 567-574
Author(s):  
Huck Jun Hong ◽  
Suw Young Ly
Keyword(s):  
Carbon Nanotube ◽  
Real Time ◽  
Anticancer Agents ◽  
Cancer Metastasis ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Takifugu Rubripes ◽  
In Vivo Detection ◽  
Voltammetric Detection

Background: Tetrodotoxin (TTX) is a biosynthesized neurotoxin that exhibits powerful anticancer and analgesic abilities by inhibiting voltage-gated sodium channels that are crucial for cancer metastasis and pain delivery. However, for the toxin’s future medical applications to come true, accurate, inexpensive, and real-time in vivo detection of TTX remains as a fundamental step. Methods: In this study, highly purified TTX extracted from organs of Takifugu rubripes was injected and detected in vivo of mouse organs (liver, heart, and intestines) using Cyclic Voltammetry (CV) and Square Wave Anodic Stripping Voltammetry (SWASV) for the first time. In vivo detection of TTX was performed with auxiliary, reference, and working herring sperm DNA-immobilized carbon nanotube sensor systems. Results: DNA-immobilization and optimization of amplitude (V), stripping time (sec), increment (mV), and frequency (Hz) parameters for utilized sensors amplified detected peak currents, while highly sensitive in vivo detection limits, 3.43 µg L-1 for CV and 1.21 µg L-1 for SWASV, were attained. Developed sensors herein were confirmed to be more sensitive and selective than conventional graphite rodelectrodes modified likewise. A linear relationship was observed between injected TTX concentration and anodic spike peak height. Microscopic examination displayed coagulation and abnormalities in mouse organs, confirming the powerful neurotoxicity of extracted TTX. Conclusion: These results established the diagnostic measures for TTX detection regarding in vivo application of neurotoxin-deviated anticancer agents and analgesics, as well as TTX from food poisoning and environmental contamination.

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