Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging

2018 ◽  
Vol 10 (4) ◽  
pp. 4271-4284 ◽  
Author(s):  
Xinghua Dong ◽  
Wenyan Yin ◽  
Xiao Zhang ◽  
Shuang Zhu ◽  
Xiao He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
Pet Imaging ◽  
Chemotherapy Resistance

Selective Inhibitors of Histone Deacetylase 10 (HDAC-10)

2021 ◽  
Vol 28 ◽  
Author(s):  
Eftiola Pojani ◽  
Daniela Barlocco
Keyword(s):  
Histone Deacetylase ◽  
Cancer Chemotherapy ◽  
Chemotherapy Resistance ◽  
Hdac Inhibitors ◽  
Selective Inhibition ◽  
Epigenetic Mechanism ◽  
Inhibitory Potency ◽  
Chemotherapy Drugs ◽  
Hydrogen Bond Interactions ◽  
Class I Hdacs

: Histone acetylation balance is one epigenetic mechanism controlling gene expression associated with disease progression. It has been observed that histone deacetylase 10 (HDAC-10) isozyme contributes to the chemotherapy resistance; in addition, the poor clinical outcome observed in patients with aggressive solid tumors, such as neuroblastoma, has been associated with its overexpression. Moreover, HDAC-10 selective inhibition suppresses the autophagic response, thus providing an improved risk-benefit profile compared to cytotoxic cancer chemotherapy drugs. On these bases, HDAC-10 is becoming an emerging target for drug design. Due to the rapid progress in the development of next-generation HDAC inhibitors, this review article aims to provide an overview on novel selective or dual HDAC-8/10 inhibitors, as new leads for cancer chemotherapy, able to avoid the severe side-effects of several actual approved “pan” HDAC inhibitors. A literature search was conducted in MedLine, PubMed, Caplus, SciFinder Scholar databases from 2015 to the present. Since the disclosure that the HDAC-6 inhibitor Tubastatin A was able to bind HDAC-10 efficiently, several related analogues were synthesized and tested. Both tricyclic (25-30) and bicyclic (31-42) derivatives were considered. The best pharmacological profile was shown by 36 (HDAC-10 pIC50 = 8.4 and pIC50 towards Class I HDACs from 5.2–6.4). In parallel, based on the evidence that high levels of HDAC-8 are a marker of poor prognosis in neuroblastoma treatment, dual HDAC-8/10 inhibitors were designed. The hydroxamic acid TH34 (HDAC-8 and 10 IC50 = 1.9 µM and 7.7 µM, respectively) and the hybrid derivatives 46d, 46e and 46g were the most promising both in terms of potency and selectivity. Literature surveys indicate several structural requirements for inhibitory potency and selectivity towards HDAC-10, e.g., electrostatic and/or hydrogen bond interactions with E274 and complementarity to the P(E,A) CE motif helix.

Acoustic disruption of tumor endothelium and on-demand drug delivery for cancer chemotherapy

2019 ◽  
Vol 30 (15) ◽  
pp. 154001 ◽  
Author(s):  
Junhua Xu ◽  
Honglei Tu ◽  
Zheng Ao ◽  
Yifan Chen ◽  
Ryan Danehy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
On Demand ◽  
Tumor Endothelium

scholarly journals CCL20 Promotes Ovarian Cancer Chemotherapy Resistance by Regulating ABCB1 Expression

2019 ◽  
Vol 44 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Shan Su ◽  
Xueqin Sun ◽  
Qinghua Zhang ◽  
Zhe Zhang ◽  
Ju Chen
Keyword(s):  
Ovarian Cancer ◽  
Cancer Chemotherapy ◽  
Chemotherapy Resistance

scholarly journals Designed construction of tween 60@2β-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 623-631 ◽  
Author(s):  
Yue Yuan ◽  
Qin Zhang ◽  
Yun Yan ◽  
Miaomiao Gong ◽  
Qi Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
Self Assembly ◽  
Drug Delivery Carrier ◽  
Tween 60

Abstract 2160: Microfragmented human fat tissue is a natural scaffold for drug delivery: potential application in cancer chemotherapy

2019 ◽  
Author(s):  
Giulio Alessandri ◽  
Valentina Coccè ◽  
Fabio Pastorino ◽  
Rita Paroni ◽  
Michele Deicas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
Potential Application ◽  
Fat Tissue
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